输血依赖型地中海贫血患者生长障碍和内分泌功能的监测及干预

doi:10.7499/j.issn.1008-8830.2501080

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摘要输血依赖型地中海贫血（transfusion-dependent thalassemia, TDT）是一种严重的遗传性、慢性溶血性疾病，生长发育迟缓是TDT患者常见临床特征。由于患者需要定期输血治疗，导致铁过载，引起多种内分泌功能障碍，包括生长激素/胰岛素样生长因子轴异常、甲状腺功能减退症、甲状旁腺功能减退、性腺功能减退症、肾上腺皮质功能不全、骨密度降低等。该文梳理了TDT患者生长障碍及相关内分泌功能的临床监测及干预措施，供临床医生参考。

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	范歆
	黄逸云

关键词 ：地中海贫血, 内分泌功能障碍, 生长发育, 铁过载, 重组人生长激素

Abstract：Transfusion-dependent thalassemia (TDT) is a severe genetic chronic hemolytic disease, and growth retardation is a common clinical feature in patients with TDT. Due to the need for regular blood transfusions, these patients often experience iron overload, which leads to various endocrine dysfunctions, including abnormalities in the growth hormone/insulin-like growth factor axis, hypothyroidism, hypoparathyroidism, hypogonadism, adrenal insufficiency, and decreased bone density. This paper reviews the clinical monitoring and intervention measures for growth disorders and related endocrine functions in patients with TDT, providing references for clinicians.

Key words： Thalassemia Endocrine dysfunction Growth and development Iron overload Recombinant human growth hormone

收稿日期: 2025-01-10

作者简介: 范歆，女，博士，主任医师。Email：fanxin602@163.com；

引用本文:

范歆,黄逸云. 输血依赖型地中海贫血患者生长障碍和内分泌功能的监测及干预[J]. 中国当代儿科杂志, 2025, 27(4): 389-394.

FAN Xin,HUANG Yi-Yun. Monitoring and interventions of growth disorders and endocrine function in children with transfusion-dependent thalassemia[J]. CJCP, 2025, 27(4): 389-394.

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