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2012 Vol.  14 No.  2
Published: 2012-02-15
OVERSEAS PEDIATRIC RESEARCH
CLINICAL RESEARCH
EXPERIMENTAL RESEARCH
CLINICAL EXPERIENCE
REVIEW
OVERSEAS PEDIATRIC RESEARCH
81 Keith K. Lau, Lucy Giglia, Howard Chan, Anthony K. Chan
Management of children after renal transplantation: highlights for general pediatricians

The number of children undergoing successful renal transplantations has been increasing steadily and as a result, general pediatricians are now more likely to encounter children with a kidney allograft in their practice. Although the medical care immediately after transplantation is mostly provided by transplant teams, more and more outpatient care will eventually be performed at the patient's local community. Medical care from general pediatricians is particularly important, especially for children who are residing far from transplant centers. As these children require prolong immunosuppressive therapies and are susceptible to various specific clinical problems, it is imperative for their primary care providers and pediatricians to be knowledgeable about their specific needs and be competent in providing care. This article highlights the roles and common practice related issues that pertain to general pediatricians in the care of pediatric renal allograft recipients.
2012 Vol. 14 (2): 81-88 [Abstract] ( 5296 ) [HTML 1KB] [PDF 1038KB] ( 1292 )
CLINICAL RESEARCH
89 HAN Ying, QIN Jiong, JIANG Yu-Wu, CHEN Jing, JI Xin-Na, LIN Qing
Co-morbidity of attention deficit hyperactivity disorder in children with epilepsy
OBJECTIVE: To estimate the prevalence of attention deficit hyperactivity disorder (ADHD) in children with epilepsy, and the factors that may contribute to the prevanlence of co-morbidity between ADHD and epilepsy. METHODS: A total of 256 children aged 6-15 years old who were diagnosed with epilepsy were enrolled. The prevalence of ADHD in children with epilepsy, and the factors that may contribute to the development of co-morbidity between ADHD and epilepsy were explored. RESULTS: The systematic evaluation in 192 patients was completed. Of the 192 children, 81 (42.2%) were diagnosed with ADHD. The earlier the epilepsy onset, the higher the frequency of the co-morbidity of ADHD occurring. The longer the period of antiepileptic medication, the higher the prevalence of the co-morbidity of ADHD. Epileptic children receiving a combination of antiepileptic drugs had a higher prevalence of ADHD. ADHD was more common in children with some specific types of epilepsy, such as Lannox-Gastaut syndrome and generalized tonic-clonic epilepsy, or epilepsy with multifocal epileptic discharges in the EEG record. CONCLUSIONS: ADHD occurs frequently in children with epilepsy. The factors associated with increased risk of ADHD include the onset age of epilepsy, the types of seizures or epileptic syndromes, the epileptiform EEG discharges, and the effects of antiepileptic drugs.
2012 Vol. 14 (2): 89-92 [Abstract] ( 5672 ) [HTML 1KB] [PDF 925KB] ( 1520 )
93 WU Jun, WU Ben-Qing, HUANG Jin-Jie, LUO Liang, TANG Yi
Risk factors and pathogen distribution in premature infants with nosocomial sepsis
OBJECTIVE: To investigate the main risk factors and pathogen distribution of nosocomial sepsis among premature infants. METHODS: The clinical data of 3418 hospitalized premature infants from January 2003 to December 2010 were retrospectively analyzed for the risk factors and pathogen distribution of nosocomial sepsis. RESULTS: The incidence of neonatal nosocomial sepsis was 3.10% (106/3418), and the median age at diagnosis of neonatal nosocomial sepsis was 19 (4-48) days. The major pathogens of the infections among these premature infants included gram-positive bacteria (45.2%), especially coagulase-negative Staphylococcus (24.3%), and gram-negative bacteria (41.7%), especially Klebsiella pneumoniae (25.2%), as well as fungus (13.0%). Logistic regression analysis showed that the main risk factors included low birth weight, retention of central venous catheters, and long duration of parenteral nutrition (OR: 3.765, 3.051, and 2.998, respectively; P<0.05). CONCLUSIONS: Low birth weight, retention of central venous catheters, and long duration of parenteral nutrition are the main risk factors for neonatal nosocomial sepsis, whereas the leading pathogen is Klebsiella pneumoniae.
2012 Vol. 14 (2): 93-96 [Abstract] ( 6094 ) [HTML 1KB] [PDF 975KB] ( 1840 )
101 ZHANG Xue-Feng, LI Ying, XIAO Gui-Hua, DAI Wen-Xia, WANG Tian-Cheng, LIU Hui, DING Cui-Ping, TONG Xiao-Mei, LIU Hui-Li, FENG Zhi-Chun, ZHAO Yin-Zhu, XIAO Ling-Ling, XU Ping, WANG Xing-Yu
Application of regionalized critical neonatal emergency transport system
OBJECTIVE: To study the application of the regional critical neonatal emergency transport system (NETS) to provide evidence for the optimization of NETS in Beijing. METHODS: All the transported neonates in four hospitals in Haidian District, Beijing, between January 2009 and September 2010 were enrolled. The relevant clinical information of two referral hospitals was analyzed. RESULTS: The top three conditions requiring transport were pre-term delivery, diseases requiring surgical treatment, and respiratory diseases, which accounted for 33.1%, 18.3%, and 14.8%, respectively. Active transport was performed in 95 cases (66.9%) and passive transport in 47 cases (33.1%). The age distribution of the neonates requiring transport was as follows: 24 hrs (40.8%). The mean time for transport from the hospital to a referral ward by ambulance was 28.0±11.1 minutes. Diseases requiring emergency surgical treatment were the leading cause of death, accounting for 53.8% of total deaths. The mortality rate was not significantly different between the neonates aged <6 hrs and ≥6 hrs groups. CONCLUSIONS: Active transport remains the main transport pattern among these four hospitals. Neonates requiring surgical treatment have a high mortality rate, and thus special attention should be paid to their transport.
2012 Vol. 14 (2): 101-104 [Abstract] ( 5512 ) [HTML 1KB] [PDF 938KB] ( 1248 )
105 ZHAO Xiao-Li, PAN Kai-Li, QIAN Xin-Hong, LI Ying-Xia, DU Li, WANG Ying-Juan, LUO Jian-Feng, ZHANG Yao, QIANG Huan
Gene expression of Notch1 and Jagged1 in children with acute leukemia
OBJECTIVE: To study the gene expression of Notch1 and Jagged1 in children with acute leukemia (AL) and their possible roles in the pathogenesis of AL. METHODS: Mononuclear cells from bone marrow or peripheral blood of 47 children with AL and 20 controls (normal children or children with nonmalignant hematologic disease) were collected from February 2009 to July 2011. A two-step method to semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) was used to detect the gene expression of Notch1 and Jagged1. Of the 47 children with AL, there were 26 cases of B-ALL, 6 cases of T-ALL and 15 cases of AML. RESULTS: The positive expression rate of Notch1 in the ALL and AML groups was higher than in the control group (P<0.05). The expression level of Notch1 in T-ALL children was higher than in B-ALL children (P<0.01). The positive expression rate of Jagged1 in the ALL and AML groups was not significantly different from the control group, however, the expression level of Jagged1 in the ALL and AML groups was higher than in the control group (P<0.05). CONCLUSIONS: There are significant differences in the gene expression of Notch1 between children with different types of ALL, and a higher expression of Notch1 relates to T-ALL. The activation of Notch1 signal is common in children with AL. The abnormal gene expression of Notch1 in children with AML shows the role of Notch1 in AML. The gene expression of Jagged1 in children with ALL or AML is abnormal, and this needs to be confirmed by further research.
2012 Vol. 14 (2): 105-109 [Abstract] ( 6578 ) [HTML 1KB] [PDF 994KB] ( 1278 )
114 ZHOU Xiong, XU Zhi-Yue, FAN Jiang-Hua, HUANG Wei
Relationship between blood lactate level and disease severity in critically ill children
OBJECTIVE: To study the relationship between blood lactate level and disease severity in critically ill children. METHODS: The clinical data of 232 children who were critically ill between September and December, 2010 were retrospectively studied. According to blood lactate levels within 24 hrs of admission, the 232 patients were classified into three groups: normal (n=146), high lacticemia (n=72) and lactic acidosis (n=14). The circulation functions, pediatric critical illness scores and prognosis were compared among the three groups. RESULTS: The degree of sepsis among the three groups was different (χ2 = 13.592, P<0.01). The occurrence of septic shock in the lactic acidosis group (42.9%) was significant compared with that in the normal (7.5%) and the high lacticemia groups (11.1%). The pediatric critical illness scores were different among the three groups (χ2 = 12.854, Ρ<0.05). The blood lactate level was significantly negatively correlated with the pediatric critical illness scores (r=-0.405, P=0.002). The prognosis among the three groups was also varied (χ2 = 25.599, P<0.01). The curative rate (7.1% vs 23.3%; Ρ<0.05) and the improvement rate (28.6% vs 58.2%; P<0.05) in the lactic acidosis group were significantly lower than in the normal group, and the mortality (28.6%) was significantly higher than in the normal (5.5%) and the high lacticemia groups (6.9%). CONCLUSIONS: A higher blood lactic acid level is associated with a more severe illness state and a worse prognosis.
2012 Vol. 14 (2): 114-116 [Abstract] ( 5528 ) [HTML 1KB] [PDF 909KB] ( 2003 )
120 CHEN Jian-Ping, ZHAO Wan-Ying, HE Nian-Hai, HE Shui-Xiang, WANG Gang, WANG Wan-Jun
Relationship between TIM-4 polymorphism and childhood asthma
OBJECTIVE: To elucidate whether the polymorphism of asthma immune regulator gene TIM-4 is associated with the risk of childhood allergic asthma in the southwest region of China. METHODS: TIM-4 gene promoter region RS6882076 and intron RS4704727 were studied. PCR-RFLP was used to test the genotypes of two polymorphism loci among 579 cases (average 7.2 years old) of asthma and 524 controls (average 7.6 years old) in a case-control study. RESULTS: There were significant differences in the frequency of gene types at RS4704727 site between the asthma and the control groups (P0.05). CONCLUSIONS: RS4704727 polymorphism of TIM-4 gene may be associated with childhood asthma, providing a better understanding of the pathogenesis of childhood asthma in the Southwest region of China.
2012 Vol. 14 (2): 120-123 [Abstract] ( 4697 ) [HTML 1KB] [PDF 919KB] ( 1092 )
124 NING Ze-Shu, ZHANG Jie, JIANG Zhi, CHEN Bo, YANG Li-Ming
Epileptiform discharges and sleep structure in children with nocturnal epilepsy
OBJECTIVE: To study the epileptiform discharges and sleep structure in children with nocturnal epilepsy. METHODS: A total of 54 children with nocturnal epilepsy (NE group) between December 2009 and June 2011 were enrolled in this study using a cluster sampling method. Their epileptiform discharges and sleep structure were monitored using nocturnal 12 h-video-echoencephalography (EEG) and polysomnography. Meanwhile, 40 age- and gender-matched normal children were enrolled as the control group. RESULTS: All the 54 children in the NE group suffered from epileptiform discharges and a varied number of clinical seizures, especially at S1 and S2 states. Compared with the control group, S1 and S2 states had significantly higher proportions in the NE group, and S3 and S4 states and REM state had significantly lower proportions (P<0.01). CONCLUSIONS: Epileptiform discharges and clinical seizures are more common in children with nocturnal epilepsy, especially during the non-rapid eye movement sleep. Meanwhile, remarkably disordered sleep structure also exists.
2012 Vol. 14 (2): 124-127 [Abstract] ( 4646 ) [HTML 1KB] [PDF 923KB] ( 1191 )
128 SHI Xu-Lai, LIN Zhong-Dong, YE Xiu-Yun, HU Ying, ZHENG Fei-Xia, HU Hong-Wen
An epidemiological survey of febrile convulsions among pupils in the Wenzhou region
OBJECTIVE: To study the prevalence and clinical features of febrile convulsion (FC) among pupils in the Wenzhou region, Zhejiang Province, China. METHODS: Using a random stratified cluster sampling method, 6406 children under 12 years from two primary schools of urban areas and two primary schools of rural areas were surveyed. RESULTS: The prevalence of FC was 3.67% (235/6406). Most children (75.7%) experienced their first onset of FC at 6 months to 3 years of age (median: 16 months). The seizures were generalized (95.3%, 224/235), with a duration of less than 10 min utes (86.4%, 203/235). FC was developed into epilepsy in 13 children (5.5%) who all sufferred from complex FC. Relapses were noted in 88 cases (37.4%), among whom 38 patients had only 1 recurrence and 50 patients had 2 or more relapses. EEG was performed in 200 cases, among whom 12(6.0%) showed abnormalities. CONCLUSIONS: The prevalence of FC is 3.67% among pupils in the Wenzhou region. The seizures are generalized, with a short duration. A part of complex FC can be developed into subsequent epilepsy.
2012 Vol. 14 (2): 128-130 [Abstract] ( 5492 ) [HTML 1KB] [PDF 909KB] ( 1105 )
131 ZHU Xin-Xin, ZHU Yu, WAN Chao-Min
Clinical features of drug-induced liver injury in children
OBJECTIVE: To study the clinical features of drug-induced liver injury in children. METHODS: The clinical data of the hospitalized children with drug-induced liver injury over 5 years were retrospectively reviewed. RESULTS: Of 641 cases of hospitalized children with liver injury, there were 64 cases (10%) of drug-induced liver injury. Hepatocellular injury was the most common type of drug-induced liver injury (81%). The major drugs causing drug-induced liver injury included chemotherapy drugs, antibiotics and anti-tuberculosis drugs. Rash (16%), gastrointestinal reaction (15%), fever (14%) and liver intumescence (12%) were common clinical symptoms. A part of patients with drug-induced liver injury (11%) had no symptoms and signs. CONCLUSIONS: Drug-induced liver injury is one of the common causes of liver damage in hospitalized children. Some children with drug-induced liver injury have no symptoms and signs. Hepatocellular injury is a major type of drug-induced liver injury in children, resulting less severe liver damage.
2012 Vol. 14 (2): 131-133 [Abstract] ( 5435 ) [HTML 1KB] [PDF 905KB] ( 1362 )
97 LIN Hui-Jia, SHI Li-Ping, LUO Fang, BAO Yu, MA Xiao-Lu
Value of radiographic assessment scale in necrotizing enterocolitis
OBJECTIVE: This study was conducted to determine the value of the radiographic assessment scale in the diagnosis of neonatal necrotizing enterocolitis, and as measured by need for surgery. METHODS: A total of 61 neonates were classified into three groups according to the Bell′s Staging Criteria: NECⅠ(n=25), NECⅡ(n=11) and NEC Ⅲ(n=25). Data on gestational age at birth, gender, birth weight, clinical manifestations, treatment and prognosis of the patients were collected. Radiographic assessment scale scores were evaluated by a pediatric radiologist. RESULTS: Radiographic assessment scale scores in the NECⅠ, NECⅡand NEC Ⅲ groups were 3.2±1.4, 5.3±1.7 and 8.9±1.7, respectively (P0.05). Radiographic assessment scale scores in neonates with intestinal perforation (9.6±1.1) were higher than in those with intestinal necrosis (6.8±1.8) (P<0.05). The majority of patients (80%) who underwent operation had radiographic assessment scale scores above 7. The effective rate was 96% and 64% respectively in the NECⅠand the NECⅡ groups. Of the children in the NECⅢ group, the cure rate was 71% in the operative group, and the effective rate was 9% in the non-operative group. CONCLUSIONS: The radiographic assessment scale may be used to evaluate the severity of disease in neonates with NEC. Patients with a score on the radiographic assessment scale above 7 have indications for surgical intervention and have better short-term treatment response rates.
2012 Vol. 14 (2): 97-100 [Abstract] ( 6187 ) [HTML 1KB] [PDF 989KB] ( 1808 )
110 LI Chang-Gang, LIU Si-Xi, MAI Hui-Rong, WANG Ying, WEN Fei-Qiu, LIU Ri-Yang, ZHANG Xin-Hua, Winnie Chiu Wing CHU, AU Wing-Yan
Evaluation of heart and liver iron deposition status in patients with β- thalassemia intermedia and major with MRI T2* technique Hot!
OBJECTIVE: To study the status of iron deposition in patients with β-thalassemia intermedia and major in mainland China. METHODS: The status of transfusion and chelation was examined in 39 patients with β-thalassemia intermedia or major. Serum ferritin levels were measured. MRI T2* technique was used to detect cardiac and hepatic iron deposition. RESULTS: Serum ferritin levels ranged from the minimum of 1500 ng/mL up to a maximum of 11491 ng/mL. From liver MRI T2* measurement, 15 cases had severe hepatic iron deposition (38%) and moderate deposition was found in 15 cases (38%), mild in 7 cases (18%), and normal in 2 cases (5%). Heart MRI T2* showed severe heart iron deposition in 7 cases (18%), mild in 5 cases (13%), and normal in 27 cases (69%). One case had cardiac arrhythmia. Four cases were over 20 years of age, and presented with gonadal function hypoplasia. The majority of patients did not receive regular transfusion and they had delayed, suboptimal chelation due to financial problems. Serum ferritin level was closely related with timing and dosage of chelation. CONCLUSIONS: In patients with β-thalassemia who do not receive early regular transfusion and iron chelation therapy, iron deposition may occur at an early age. Important organs and tissue functional lesions and related complications also result. Relevant agencies and family members should be aware of this trend and develop appropriate strategies to improve the medical condition and quality of life of patients with this disorder.
2012 Vol. 14 (2): 110-113 [Abstract] ( 5374 ) [HTML 1KB] [PDF 1016KB] ( 1498 )
117 JIANG Feng, MA Xiang-Ping, Duolikun MUZHAPAER
Correlation between insulin resistance and myocardial injury in critically ill children
OBJECTIVE: To study the relationship between insulin resistance and myocardial injury in children with critical diseases in light of the fact that such children usually suffer from noticeable insulin resistance and myocardial injury. METHODS: Sixty-three children with critical diseases who were admitted between March 2010 and June 2011 were enrolled to comprise a case group. Fasting blood glucose, serum insulin, myocardial enzyme, and troponin I (CTnI) levels were measured. The insulin resistance index (HOMA-IR) was calculated. The children were classified into two groups: insulin resistance (HOMA-IR>1.0; n=30) and non-insulin resistance (HOMA-IR≤1.0; n=33). Thirty healthy children served as the control group. RESULTS: HOMA-IR, lactate dehydrogenase (LDH), aspartate aminotransferaseaspartate transaminase (AST), creatine kinase (CK), isoenzymes of creating kinase (CK-MB), α-hydroxybuty rate dehydrogenase (α-HBDH) and CTnI in the insulin resistance group were higher than those in the non-insulin resistance and the control groups (all P<0.05). The non-insulin resistance group also showed obviously higher levels in terms of LDH, AST, CK, CK-MB, α-HBDH, and CTnI than the control group (P<0.05). In the insulin resistance group, there exists a positive correlation between HOMA-IR and such indicators as LDH, CK, CK-MB, AST, α-HBDH and CTnI (r=0.697, 0.739, 0.781, 0.642, 0.381, 0.792 respectively; all P<0.05). CONCLUSIONS: Insulin resistance makes myocardial injury more serious; HOMA-IR can serve as a forecast indicator for the degree of myocardial injury.
2012 Vol. 14 (2): 117-119 [Abstract] ( 4487 ) [HTML 1KB] [PDF 909KB] ( 1098 )
152 ZHANG Li-Na, LIANG Li-Yang, MENG Zhe, CHEN Rui-Han, LI Dong-Fang, HE Zhan-Wen
Neonatal pituitary stalk interruption syndrome: a case report
No abstract available
2012 Vol. 14 (2): 152-153 [Abstract] ( 4310 ) [HTML 1KB] [PDF 998KB] ( 1221 )
EXPERIMENTAL RESEARCH
134 WANG Yu, LU Zhu-Jin
Recruitment maneuver in the treatment of young piglets with acute lung injury
OBJECTIVE: To study the feasibility, efficiency and any benefits of recruitment maneuver (RM) in the facilitation of lung repair during recovery from ALI in acute lung injury (ALI) model of young piglets. METHODS: The piglet model of ALI was established by an intravenous injection of lipopolysaccharide (LPS). Twelve ALI piglets were randomly divided into two groups: conventional ventilation (CON) and RM with low tidal volume. Arterial blood gas, dynamic lung compliance (Cdyn) and systematic hemodynamics were monitored during the treatment. TGF-β1 levels in bronchoalveolar lavage fluid (BALF) and plasma were measured. The mRNA expression of TGF-β1 in the lungs was assessed by real time PCR. Lung tissue was examined for morphological changes. RESULTS: No significant difference was observed in cardiac output and peripheral vascular resistance (PVR) between the two groups. The extravascular lung water index (ELWI) from 6 hrs after ALI inducement and the pulmonary vascular permeability index (PVPI) 8 hrs after ALI inducement in the RM group decreased significantly compared with the CON group. Cdyn in the RM group increased quickly 1 hr after ALI inducement, and there was a significant difference between the two groups (P<0.05). P/F (ratio of PaO2 to FiO2) in the RM group was significantly higher than in the CON group from 2 hrs after ALI inducement (P<0.05). Alveolar-to-arterial oxygen difference in the RM group was obviously lower compared with the CON group from 2 hrs after ALI inducement (P<0.05). The levels of TGF-β1 in plasma and BALF and the mRNA expression of TGF-β1 in the lung tissue were lower than in the CON group. Volume density of alveolar aeration in the RM group was significantly higher than in the CON group, and the injury score in the RM group was lower (P<0.05). CONCLUSIONS: RM can improve gas exchange and Cdyn in the treatment of piglets with ALI. RM is a safe and effective approach to alveolar recruitment and can alleviate ventilation induced lung injury.
2012 Vol. 14 (2): 134-138 [Abstract] ( 4557 ) [HTML 1KB] [PDF 1044KB] ( 1154 )
139 CHEN Guang-Fu, ZHANG Yun-Fang, LONG Qi, WEN Wen, XU Mei-Quan, YANG Ya-Ling
Effects of environmental enrichment on the repair and proliferation of neurons in neonatal rats with hypoxic-ischemic brain damage
OBJECTIVE: To study the effects of environmental enrichment on neuron proliferation, learning and memory ability and motor ability in neonatal rats with hypoxic-ischemic brain damage (HIBD). METHODS: One hundred and eight 7-day-old Sprague-Dawley rats were randomly divided into three groups: sham operation (CON group), HIBD and intervention group. HIBD model was prepared according to the classic Rice-Vannucci method. Environmental enrichment was administered for the rats in the intervention group after HIBD inducement. Behavioral tests (Water maze test, Suspension test and Slope test) were performed and the number of neural cells in the left hippocampus was examined 7, 14 and 28 days after intervention. RESULTS: The pyramid cells in the hippocampus CA1 area in the HIBD group were significantly less than in the CON group at 7, 14 and 28 days (P<0.05). The number of pyramid cells in the hippocampus CA1 area in the intervention group was significantly higher than in the HIBD group (P<0.01) at 7, 14 and 28 days. The hidden platform escape latency period (EL) in the Water maze test was significantly more prolonged and the cross-platform number within 2 minutes was significantly less in the HIBD and the intervention groups than in the CON group at all observed time points (P<0.01). The EL was significantly shorter and the cross-platform number within 2 minutes was significantly higher in the intervention group than in the HIBD group at all observed time points (P<0.01). The maintain time and score in the Suspension test were significantly lower and the time in the Slope test was significantly more prolonged in the HIBD and intervention groups than in the CON group at 7, 14 and 28 days (P<0.01). An increased maintain time and score and a decreased time in the Slope test were found in the intervention group compared with the HIBD group at 14 and 28 days (P<0.01). CONCLUSIONS: Environmental enrichment can improve motor function, learning and memory ability, and promote the repair and proliferation of neurons in neonatal rats with HIBD.
2012 Vol. 14 (2): 139-143 [Abstract] ( 5539 ) [HTML 1KB] [PDF 1412KB] ( 1187 )
CLINICAL EXPERIENCE
144 YANG Wen-Li, SANG Yan-Mei, LIU Min, GU Yi, ZHU Cheng, NI Gui-Chen
Clinical analysis of permanent neonatal diabetes mellitus in 10 cases
No abstract available
2012 Vol. 14 (2): 144-146 [Abstract] ( 3818 ) [HTML 1KB] [PDF 902KB] ( 1182 )
147 ZHU Ying, DONG Yang, XU Da-Liang, JIANG Jia-Yun, XU Yuan
Application of continuous blood purification in critically ill children
No abstract available
2012 Vol. 14 (2): 147-149 [Abstract] ( 3800 ) [HTML 1KB] [PDF 908KB] ( 1124 )
150 LI Fan, HE Ying
Misdiagnosis analysis of childhood ovary disease in 10 cases
No abstract available
2012 Vol. 14 (2): 150-151 [Abstract] ( 2980 ) [HTML 1KB] [PDF 881KB] ( 1120 )
REVIEW
154 HUANG Dan-Lin, YI Zhu-Wen
Application of stem cell transplantation in kidney diseases
This paper summarizes the current literature on the potential therapeutic role of stem cell transplantation for kidney injury and repair and focuses on the choice of types of stem cells, the method of transplantation, and the mechanisms of stem cell homing to injured renal tissues and its protective effects. The application of umbilical cord mesenchymal stem cells (UC-MSCs) shows wide prospects, but the approach and optimal dose of cell transplantation are under intensive investigation. Signals that regulate stem cell homing to injured renal tissues may be related to chemokines or factors released in the target site. Several studies have pointed out that paracrine and endocrine of stem cells are the most likely mechanism of action in the injured nephron. Many questions remain unanswered but stem cell-based therapy is a promising new strategy for acute and chronic kidney diseases.
2012 Vol. 14 (2): 154-160 [Abstract] ( 5942 ) [HTML 1KB] [PDF 969KB] ( 1891 )
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