先天性膈疝继发新生儿持续肺动脉高压的研究进展

肖斌; 刘敏; 徐畅

doi:10.7499/j.issn.1008-8830.2015.09.025

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中国当代儿科杂志 ›› 2015, Vol. 17 ›› Issue (9) : 1013-1019. DOI: 10.7499/j.issn.1008-8830.2015.09.025

综述

先天性膈疝继发新生儿持续肺动脉高压的研究进展

肖斌, 刘敏, 徐畅

作者信息 +

Research advances in persistent pulmonary hypertension of the newborn secondary to congenital diaphragmatic hernia

XIAO Bin, LIU Min, XU Chang

Author information +

文章历史 +

摘要

先天性膈疝(CDH)继发新生儿持续性肺动脉高压(PPHN)是新生儿高病死率的重要原因之一,是导致CDH 患儿生后出现呼吸、循环衰竭的重要因素。CDH 继发PPHN 的病情危重,治疗困难,治疗预后差,故针对阻止CDH 病理进程的产前干预已成为研究热点,尤其是关于阻断PPHN 形成过程的病因治疗。鉴于PPHN 的病因尚不明确,治疗效果差,该文以国内外相关研究为基础,综述CDH-PPHN 的发病机制与治疗研究进展,以期为相关研究与临床治疗提供参考

Abstract

Persistent pulmonary hypertension of the newborn (PPHN) secondary to congenital diaphragmatic hernia (CDH) is one of the main reasons for high mortality of the newborn and a factor that leads to respiratory and circulatory failure in newborns with CDH. PPHN secondary to CDH is severe and difficult to treat, with poor prognosis. Therefore, prenatal intervention aims for preventing the pathological process of CDH, especially the etiological treatment for impeding the development of PPHN, has become a research focus. Given unknown causes and poor outcomes of PPHN, this article summarizes the research advances in pathogenesis and treatment of PPHN secondary to CDH based on related studies so as to provide a reference for relevant studies and clinical treatment.

导出引用

肖斌, 刘敏, 徐畅. 先天性膈疝继发新生儿持续肺动脉高压的研究进展[J]. 中国当代儿科杂志. 2015, 17(9): 1013-1019 https://doi.org/10.7499/j.issn.1008-8830.2015.09.025

XIAO Bin, LIU Min, XU Chang. Research advances in persistent pulmonary hypertension of the newborn secondary to congenital diaphragmatic hernia[J]. Chinese Journal of Contemporary Pediatrics. 2015, 17(9): 1013-1019 https://doi.org/10.7499/j.issn.1008-8830.2015.09.025

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