Association between gene polymorphism of CD40 gene and coronary artery lesion in Kawasaki disease

CHENG Shou-Chao; CHENG Yan-Yang; WU Jin-Long

doi:10.7499/j.issn.1008-8830.2014.10.013

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Chinese Journal of Contemporary Pediatrics ›› 2014, Vol. 16 ›› Issue (10) : 1025-1028. DOI: 10.7499/j.issn.1008-8830.2014.10.013

CLINICAL RESEARCH

Association between gene polymorphism of CD40 gene and coronary artery lesion in Kawasaki disease

CHENG Shou-Chao, CHENG Yan-Yang, WU Jin-Long

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Abstract

Objective To study the association between two single nucleotide polymorphisms (rs4810485 and rs1535045 in CD40 gene) and Kawasaki disease (KD) in Han Chinese children. Methods A case-control study was performed on 184 children with KD and 206 normal controls. The polymorphisms of two SNPs in CD40 gene were detected using PCR-RFLP. Results There were no significant differences in the genotype distribution and allele frequency of SNP rs4810485 in CD40 gene between the KD and normal groups (P>0.05). The genotype distribution of SNP rs1535045 in CD40 gene in the KD group was significantly different from the control group (P<0.05). T allele of SNP rs1535045 was shown as a risk factor for development of KD (OR=1.592, 95%CI: 1.182-2.144, P=0.004). There were no association between the polymorphisms of the two SNPs and coronary artery lesions (P>0.05). Conclusions SNP rs1535045 may be associated with the development of KD in Han Chinese children, while SNP rs4810485 may not.

Key words

Kawasaki disease / CD40 gene / Polymorphism / Coronary artery lesion / Child

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CHENG Shou-Chao, CHENG Yan-Yang, WU Jin-Long. Association between gene polymorphism of CD40 gene and coronary artery lesion in Kawasaki disease[J]. Chinese Journal of Contemporary Pediatrics. 2014, 16(10): 1025-1028 https://doi.org/10.7499/j.issn.1008-8830.2014.10.013

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