Short-term prognostic factors in children with acute liver failure

PEI Liang; WEN Guang-Fu; GUO Zhang-Yan; SONG Wen-Liang; WANG Li-Jie; LIU Chun-Feng

doi:10.7499/j.issn.1008-8830.2014.12.013

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Chinese Journal of Contemporary Pediatrics ›› 2014, Vol. 16 ›› Issue (12) : 1250-1254. DOI: 10.7499/j.issn.1008-8830.2014.12.013

CLINICAL RESEARCH

Short-term prognostic factors in children with acute liver failure

PEI Liang, WEN Guang-Fu, GUO Zhang-Yan, SONG Wen-Liang, WANG Li-Jie, LIU Chun-Feng

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Abstract

Objective To investigate the factors that influence the short-term (6 months) prognosis in children with acute liver failure. Methods The clinical information of 53 children with acute liver failure treated between June 2008 and September 2013 was retrospectively analyzed. The patients were divided into survival group (n=21) and death group (n=32) according to their outcomes. The liver function parameters and incidence of complications were compared between the two groups, and multivariate logistic regression analysis was used to identify major factors affecting the short-term prognosis in these patients. Results There were significant differences between the death and survival groups in the indices of international normalized ratio (INR), blood ammonia and serum albumin (Alb), and complications such as hepatic encephalopathy, gastrointestinal hemorrhage, and multiple organ failure (P<0.05). Multivariate logistic regression analysis demonstrated that serum Alb, INR, and hepatic encephalopathy were the major factors affecting the short-term prognosis of acute liver failure (OR=0.616, 75.493 and 1210.727 respectively; P<0.05). Conclusions INR, hepatic encephalopathy and serum Alb are the major factors that influence the short-term prognosis in children with acute liver failure.

Key words

Acute liver failure / Prognostic factor / Child

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PEI Liang, WEN Guang-Fu, GUO Zhang-Yan, SONG Wen-Liang, WANG Li-Jie, LIU Chun-Feng. Short-term prognostic factors in children with acute liver failure[J]. Chinese Journal of Contemporary Pediatrics. 2014, 16(12): 1250-1254 https://doi.org/10.7499/j.issn.1008-8830.2014.12.013

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