Prevalence of respiratory syncytial virus infection in hospitalized children at a children's hospital and effects of climate change on the prevalence in Suzhou, China

GENG Jia; GUO Wan-Liang; ZHANG Xue-Lan

doi:10.7499/j.issn.1008-8830.2015.05.014

PDF(1521 KB)

Chinese Journal of Contemporary Pediatrics ›› 2015, Vol. 17 ›› Issue (5) : 482-486. DOI: 10.7499/j.issn.1008-8830.2015.05.014

CLINICAL RESEARCH

Prevalence of respiratory syncytial virus infection in hospitalized children at a children's hospital and effects of climate change on the prevalence in Suzhou, China

GENG Jia¹, GUO Wan-Liang², ZHANG Xue-Lan¹

Author information +

History +

Abstract

Objective To investigate the prevalence of respiratory syncytial virus (RSV) infection in hospitalized children and the relationship between the prevalence and the climate change in Suzhou, China. Methods A total of 42 664 nasopharyngeal secretions from hospitalized children with acute respiratory infection at the Suzhou Children's Hospital were screened for RSV antigens using direct immunofluorescence. Monthly meteorological data (mean monthly air temperature, monthly relative humidity, monthly rainfall, total monthly sunshine duration, and mean monthly wind velocity) in Suzhou between 2001 and 2011 were collected. The correlations between RSV detection rate and climatic factors were evaluated using correlation and stepwise regression analysis. Results The annual RSV infection rate in hospitalized children with respiratory infection in the Suzhou Children's Hospital varied between 11.85% and 27.30% from 2001 to 2011. In the 9 epidemic seasons, each spanning from November to April of the next year, from 2001 to 2010, the RSV detection rates were 40.75%, 22.72%, 39.93%, 27.37%, 42.71%, 21.28%, 38.57%, 19.86%, and 29.73%, respectively; there were significant differences in the detection rate between the epidemic seasons. The monthly RSV detection rate was negatively correlated with mean monthly air temperature, total monthly sunshine duration, monthly rainfall, monthly relative humidity, and mean monthly wind velocity (P<0.05). Stepwise regression analysis showed that mean monthly air temperature fitted into a linear model (R²=0.64, P<0.01). Conclusions From 2001 to 2011, RSV infection in Suzhou was predominantly prevalent between November and April of the next year. As a whole, the infection rate of RSV reached a peak every other year. Air temperature played an important role in the epidemics of RSV infection in Suzhou.

Key words

Respiratory syncytial virus / Climate / Respiratory tract infection / Child

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

GENG Jia, GUO Wan-Liang, ZHANG Xue-Lan. Prevalence of respiratory syncytial virus infection in hospitalized children at a children's hospital and effects of climate change on the prevalence in Suzhou, China[J]. Chinese Journal of Contemporary Pediatrics. 2015, 17(5): 482-486 https://doi.org/10.7499/j.issn.1008-8830.2015.05.014

References

[1] Nair H, Nokes DJ, Gessner BD, et al. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis[J]. Lancet, 2010, 375(9725): 1545-1555.
[2] Guo W, Wang J, Sheng M, et al. Radiological findings in 210 paediatric patients with viral pneumonia: a retrospective case study[J]. Br J Radiol, 2012, 85(1018): 1385-1389.
[3] 刘华, 贺湘玲, 张兵, 等. 255例急性下呼吸道感染并血小板异常患儿病毒病原学分析[J]. 中国当代儿科杂志, 2014, 16(4): 406-409.
[4] Rodríguez-Auad JP, Nava-Frías M, Casasola-Flores J, et al. The epidemiology and clinical characteristics of respiratory syncytial virus infection in children at a public pediatric referral hospital in Mexico[J]. Int J Infect, 2012, 16(7): e508- e513.
[5] 胡亚美, 江载芳. 诸福棠实用儿科学[M]. 第7版. 北京: 人民卫生出版社出版, 2002: 163-199.
[6] Ji W, Wang Y, Chen Z, et al. Human metapneumovirus in children with acute respiratory tract infections in Suzhou, China 2005-2006[J]. Scand J Infect Dis, 2009, 41(10): 735-744.
[7] 邓洁, 钱渊, 朱汝南, 等. 2000年冬~2006年春北京地区急性呼吸道感染患儿中呼吸道合胞病毒的监测[J].中华儿科杂志, 2006, 44(12): 924-927.
[8] Miernyk K, Bulkow L, DeByle C, et al. Performance of a rapid antigen test (Binax NOW® RSV) for diagnosis of respiratory syncytial virus compared with real-time polymerase chain reaction in a pediatric population[J]. J Clin Virol, 2011, 50(3): 240-243.
[9] Thompson WW, Shay DK, Weintraub E, et al. Mortality associated with influenza and respiratory syncytial virus in the United States[J]. JAMA, 2003, 289(2): 179-186.
[10] Berkley JA, Munywoki P, Ngama M, et al. Viral etiology of severe pneumonia among Kenyan infants and children[J]. JAMA, 2010, 303(20): 2051-2057.
[11] Haque F, Husain MM, Ameen KM, et al. Bronchiolitis outbreak caused by respiratory syncytial virus in southwest Bangladesh, 2010[J]. Int J Infect Dis, 2012, 16(12): e866-e871.
[12] Chen ZR, Ji W, Wang YQ, et al. Etiology of acute bronchiolitis and the relationship with meteorological conditions in hospitalized infants in China[J]. J Formos Med Assoc, 2014, 113(7): 463-469.
[13] Yusuf S, Piedimonte G, Auais A, et al. The relationship of meteorological conditions to the epidemic activity of respiratory syncytial virus[J]. Epidemiol Infect, 2007, 135(7): 1077-1090.
[14] 张学兰, 季伟, 季正华, 等. 苏州地区呼吸道合胞病毒及相关支气管肺炎患儿的流行病学研究[J]. 中华预防医学杂志, 2007, 41(5): 371-374.
[15] Manoha C, Espinosa S, Aho SL, et al. Epidemiological and clinical features of hMPV, RSV and RVs infections in young children[J]. J Clin Virol, 2007, 38(3): 221-226.
[16] van der Sande MA, Goetghebuer T, Sanneh M, et al. Seasonal variation in respiratory syncytial virus epidemics in the Gambia, West Africa[J]. Pediatr Infect Dis J, 2004, 23(1): 73-74.
[17] du Prel JB, Puppe W, Gröndahl B, et al. Are meteorological parameters associated with acute respiratory tract infections? [J]. Clin Infect Dis, 2009, 15, 49(6): 861-868.
[18] Madhi SA, Kuwanda L, Cutland C, et al. Five-year cohort study of hospitalization for respiratory syncytial virus associated lower respiratory tract infection in African children[J]. J Clin Virol, 2006, 36(3): 215-221.