Association between tumor necrosis factor-α G-308A polymorphisms and genetic susceptibility to spontaneous preterm birth

PENG Wei; YANG Xiao; ZHU Li-Na; ZHANG Xiao-Ai; WANG Yan

doi:10.7499/j.issn.1008-8830.2016.12.010

PDF(1491 KB)

Chinese Journal of Contemporary Pediatrics ›› 2016, Vol. 18 ›› Issue (12) : 1247-1253. DOI: 10.7499/j.issn.1008-8830.2016.12.010

CLINICAL RESEARCH

Association between tumor necrosis factor-α G-308A polymorphisms and genetic susceptibility to spontaneous preterm birth

PENG Wei¹, YANG Xiao¹, ZHU Li-Na¹, ZHANG Xiao-Ai², WANG Yan¹

Author information +

History +

Abstract

Objective To study the association between tumor necrosis factor-α (TNF-α) G-308A polymorphisms and genetic susceptibility to spontaneous preterm birth (SPTB). Methods The case group enrolled 753 SPTB infants and the control group included 681 term infants. TNF-α G-308A polymorphisms were genotyped using Sequenom MassARRAY^® SNP. Results The frequencies of the allele (G and A) in the case and control groups were not significantly different (P=0.35). The frequencies of the genotypes (GG, GA and AA) in the case and control groups were not significantly different (P=0.64). The logistic regression analysis found that TNF-α G-308A was not associated with genetic susceptibility to SPTB (OR=0.85; 95%CI:0.61-1.19;P=0.35). Conclusions There is no association between the polymorphisms of TNF-α G-308A and the genetic susceptibility to SPTB.

Key words

Tumor necrosis factor-α / Spontaneous preterm birth / Single nucleotide polymorphism / Preterm infant

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

PENG Wei, YANG Xiao, ZHU Li-Na, ZHANG Xiao-Ai, WANG Yan. Association between tumor necrosis factor-α G-308A polymorphisms and genetic susceptibility to spontaneous preterm birth[J]. Chinese Journal of Contemporary Pediatrics. 2016, 18(12): 1247-1253 https://doi.org/10.7499/j.issn.1008-8830.2016.12.010

References

[1] Damus K. Prevention of preterm birth:a renewed national priority[J]. Curr Opin Obstet Gynecol, 2008, 20(6):590-596.
[2] Winkvist A, Mogren I, Hogberg U. Familial patterns in birth characteristics:impact on individual and population risks[J]. Int J Epidemiol, 1998, 27(2):248-254.
[3] 张建平. 异常妊娠[M]//谢幸, 苟文丽. 妇产科学. 第8版. 北京:人民卫生出版社, 2013:47-63.
[4] Di Renzo GC, Giardina I, Rosati A, et al. Maternal risk factors for preterm birth:a country-based population analysis[J]. Eur J Obstet Gynecol Reprod Biol, 2011, 159(2):342-346.
[5] Hamilton BE, Martin JA, Ventura SJ. Births:preliminary data for 2012[J]. Natl Vital Stat Rep, 2013, 62(3):1-20.
[6] Goldenberg RL, Culhane JF, Iams JD, et al. Epidemiology and causes of preterm birth[J]. Lancet, 2008, 371(9606):75-84.
[7] Weissenbacher T, Laubender RP, Witkin SS, et al. Diagnostic biomarkers of pro-inflammatory immune-mediated preterm birth[J]. Arch Gynecol Obstet, 2013, 287(4):673-685.
[8] Nelson KB, Dambrosia JM, Iovannisci DM, et al. Genetic polymorphisms and cerebral palsy in very preterm infants[J]. Pediatr Res, 2005, 57(4):494-499.
[9] Strassberg SS, Cristea IA, Qian D, et al. Single nucleotide polymorphisms of tumor necrosis factor-alpha and the susceptibility to bronchopulmonary dysplasia[J]. Pediatr Pulmonol, 2007, 42(1):29-36.
[10] Nuk M, Orendi K, Rosenberger S, et al. Genetic variations in fetal and maternal tumor necrosis factor-alpha and interleukin 10:is there an association with preterm birth or periventricular leucomalacia?[J]. J Perinatol, 2012, 32(1):27-32.
[11] Wang Y, Zhang XA, Yang X, et al. A MCP-1 promoter polymorphism at G-2518A is associated with spontaneous preterm birth[J]. Mol Genet Genomics, 2015, 290(1):289-296.
[12] Wang Y, Yang X, Zheng Y, et al. The SEPS1 G-105A polymorphism is associated with risk of spontaneous preterm birth in a Chinese population[J]. PLoS One, 2013, 8(6):e65657.
[13] Bowen JM, Chamley L, Keelan JA, et al. Cytokines of the placenta and extra-placental membranes:roles and regulation during human pregnancy and parturition[J]. Placenta, 2002, 23(4):257-273.
[14] Romero R, Espinoza J, Kusanovic JP, et al. The preterm parturition syndrome[J]. BJOG, 2006, 113(Suppl 3):17-42.
[15] Aidoo M, McElroy PD, Kolczak MS, et al. Tumor necrosis factor-alpha promoter variant 2(TNF2) is associated with pre-term delivery, infant mortality, and malaria morbidity in western Kenya:Asembo Bay Cohort Project IX[J]. Genet Epidemiol, 2001, 21(3):201-211.
[16] Yilmaz Y, Verdi H, Taneri A, et al. Maternal-fetal proinflammatory cytokine gene polymorphism and preterm birth[J]. DNA Cell Biol, 2012, 31(1):92-97.
[17] Macones GA, Parry S, Elkousy M, et al. A polymorphism in the promoter region of TNF and bacterial vaginosis:preliminary evidence of gene-environment interaction in the etiology of spontaneous preterm birth[J]. Am J Obstet Gynecol, 2004, 190(6):1504-1508.
[18] 陈大方, 胡永华, 吴白燕, 等. 肿瘤坏死因子α/G308A多态性与早产的关联性研究[J].北京大学学报(医学版), 2003, 35(4):377-381.