Abstract：Objective To study the effect of ketogenic diet (KD) on neurobehavioral development, emotional and social behaviors, and life ability in children with global developmental delay (GDD). Methods A prospective case-control study was performed for hospitalized children with GDD, who were randomly divided into KD treatment group (n=40) and conventional treatment group (n=37). The children in both groups were given comprehensive rehabilitation training, and those in the KD treatment group were given modified Atkins diet in addition to the comprehensive rehabilitation training. The children in both groups were assessed with the Gesell Developmental Scale, Chinese version of Urban Infant-Toddler Social and Emotional Assessment (CITSEA)/Achenbach Child Behavior Checklist (CBCL), and Infants-Junior High School Students' Social Life Abilities Scale (S-M scale) before treatment and after 3, 6, and 9 months of treatment. The two groups were compared in terms of the improvements in neurobehavioral development, emotional and social behaviors, and social life ability. Results After 3, 6, and 9 months of treatment, the KD treatment group had significantly greater improvements in the scores of the adaptive, fine motor, and language quotients of the Gesell Developmental Scale compared with the conventional treatment group (P < 0.05); the KD treatment group had significantly greater improvements in CITSEA/CBCL scores than the conventional treatment group (P < 0.05). The KD treatment group had a greater improvement in the score of the S-M scale after 9 months of treatment (P < 0.05). During the KD treatment, 6 children experienced diarrhea and 1 experienced mild urinary stones. Conclusions KD can improve the neurobehavioral development and behavioral and emotional behaviors in children with GDD, and it has few adverse effects.
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