Expression and significance of endothelial microparticles in children with HenochSchönlein purpura
FU Shu-Qin, GUO Yan-Jun, SONG Chun-Lan
Children's Hospital of Zhengzhou University/Children's Hospital of Henan Province/Zhengzhou Children's Hospital/Zhengzhou Children's Critical Medical Key Laboratory, Zhengzhou 450000, China
Abstract：Objective To study the expression and significance of endothelial microparticles (EMPs) in children with Henoch-Schönlein purpura (HSP). Methods A total of 100 previously untreated children with HSP were classified to Henoch-Schönlein purpura nephritis (HSPN) group (n=40) and non-nephritis group (n=60). Thirty healthy children who underwent physical examination were enrolled as control group. Serum levels of EMPs, T helper 17 cells (Th17), and interleukin-17 (IL-17) were compared between groups. Results The HSPN and non-nephritis groups had significantly higher levels of Th17 and IL-17 than the control group, and the HSPN group had the highest levels (P P r=0.830 and 0.644 respectively; P Conclusions EMPs play an important role in the pathogenesis of HSP. The increase in EMPs might be one of the reasons for renal involvement in children with HSP.
FU Shu-Qin,GUO Yan-Jun,SONG Chun-Lan. Expression and significance of endothelial microparticles in children with HenochSchönlein purpura[J]. CJCP, 2018, 20(10): 831-834.
Ozen S, Ruperto N, Dillon MJ, et al. EULAR/PReS endorsed consensus criteria for the classification of childhood vasculitides[J]. Ann Rheum Dis, 2006, 65(7):936-941.
Nazari A, Zahmatkesh M, Mortaz E, et al. Effect of methamphetamine exposure on the plasma levels of endothelialderived microparticles[J]. Drug Alcohol Depend, 2018, 186:219-225.
[8]
Mezentsev A, Merks RM, O'Riordan E, et al. Endothelial microparticles affect angiogenesis in vitro:role of oxidative stress[J]. Am J Physiol Heart Circ Physiol, 2005, 289(3):H1106-H1114.
[9]
Alari-Pahissa E, Notario L, Lorente E, et al. CD69 does not affect the extent of T cell priming[J]. PLoS One, 2012, 7(10):e48593.
