重组人生长激素在治疗慢性肾脏病儿童生长障碍中的应用和思考

doi:10.7499/j.issn.1008-8830.2410023

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摘要生长障碍是儿童慢性肾脏病（chronic kidney disease, CKD）较为常见的并发症之一，对CKD儿童的生活质量和生存期均产生不良影响。重组人生长激素是治疗CKD儿童生长障碍的有效方法。该文对CKD儿童生长障碍的发生机制，重组人生长激素的治疗效果、安全性、注意事项，以及诊疗长期管理进行综述。

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	周建华

关键词 ：慢性肾脏病, 生长障碍, 重组人生长激素, 儿童

Abstract：Growth disorders are one of the common complications of chronic kidney disease (CKD) in children, adversely affecting both the quality of life and survival time of CKD patients. Recombinant human growth hormone (rhGH) is an effective treatment for growth disorders in children with CKD. This article reviews the mechanisms underlying growth disorders in children with CKD, the therapeutic effects, safety, and precautions of rhGH, and long-term management of diagnosis and treatment of this disorder.

Key words： Chronic kidney disease Growth disorder Recombinant human growth hormone Child

收稿日期: 2024-10-11

作者简介: 周建华，男，博士，主任医师。Email：jhzhou99@qq.com；

引用本文:

周建华. 重组人生长激素在治疗慢性肾脏病儿童生长障碍中的应用和思考[J]. 中国当代儿科杂志, 2025, 27(2): 133-138.

ZHOU Jian-Hua. Application and considerations of recombinant human growth hormone in treating growth disorders in children with chronic kidney disease[J]. CJCP, 2025, 27(2): 133-138.

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http://www.zgddek.com/CN/10.7499/j.issn.1008-8830.2410023 或 http://www.zgddek.com/CN/Y2025/V27/I2/133

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