Abstract：Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease that affects multiple organs and systems. It is more common in women of childbearing age. Compared with the general population, pregnant women with SLE are at a significantly increased risk of adverse perinatal outcomes such as preterm birth and intrauterine growth restriction. In addition, the offspring of SLE patients may also be adversely affected by in utero exposure to maternal autoantibodies, cytokines, and drugs. This article summarizes the long-term developmental outcomes of offspring of pregnant women with SLE in terms of the blood system, circulatory system, nervous system, and immune system. Citation:Chinese Journal of Contemporary Pediatrics, 2023, 25(4): 415-419
SHAO Shu-Ming,ZHANG Yi-Min. Research progress on long-term developmental outcomes of offspring of pregnant women with systemic lupus erythematosus[J]. CJCP, 2023, 25(4): 415-419.
Tani C, Zucchi D, Haase I, et al. Are remission and low disease activity state ideal targets for pregnancy planning in systemic lupus erythematosus? A multicentre study[J]. Rheumatology (Oxford), 2021, 60(12): 5610-5619. PMID: 33590843. DOI: 10.1093/rheumatology/keab155.
Xiong ZH, Cao XS, Guan HL, et al. Immunotherapies application in active stage of systemic lupus erythematosus in pregnancy: a case report and review of literature[J]. World J Clin Cases, 2020, 8(24): 6396-6407. PMID: 33392323. PMCID: PMC7760451. DOI: 10.12998/wjcc.v8.i24.6396.
Conklin J, Golpanian M, Engel A, et al. Erythrocyte complement receptor 1 (ECR1) and erythrocyte-bound C4d (EC4d) in the prediction of poor pregnancy outcomes in systemic lupus erythematosus (SLE)[J]. Lupus Sci Med, 2022, 9(1):e000754. PMID: 36755365. PMCID: PMC9445792. DOI: 10.1136/lupus-2022-000754.
5 Zhang LL, Shu H, Zhang S, et al. Pregnancy outcomes and risk factors in pregnant women with systemic lupus erythematosus[J]. Clin Exp Obstet Gynecol, 2020, 47(2): 189-193. DOI: 10.31083/j.ceog.2020.02.5043.
Lu Y, Yu Y, Xia W, et al. Pregnancy outcomes in different stages of systemic lupus erythematosus among Chinese women: a retrospective cohort study[J]. Ginekol Pol, 2021, 92(5): 365-370. PMID: 33751514. DOI: 10.5603/GP.a2020.0151.
Andreoli L, Lazzaroni MG, Carini C, et al. "Disease knowledge index" and perspectives on reproductive issues: a nationwide study on 398 women with autoimmune rheumatic diseases[J]. Joint Bone Spine, 2019, 86(4): 475-481. PMID: 30579917. DOI: 10.1016/j.jbspin.2018.12.002.
Nalli C, Galli J, Lazzaroni MG, et al. Long-term outcome of children born from mothers with autoimmune diseases[J]. Best Pract Res Clin Obstet Gynaecol, 2020, 64: 107-116. PMID: 31787531. DOI: 10.1016/j.bpobgyn.2019.11.003.
Gariup M, Lera-Miguel S, Torres F, et al. Autoantibodies, elevated cytokines, and neurocognitive abnormalities in offspring of women with systemic lupus erythematosus: comparison with healthy controls[J]. Clin Rheumatol, 2019, 38(9): 2529-2539. PMID: 31020474. DOI: 10.1007/s10067-019-04495-4.
Wu Y, Espinosa KM, Barnett SD, et al. Association of elevated maternal psychological distress, altered fetal brain, and offspring cognitive and social-emotional outcomes at 18 months[J]. JAMA Netw Open, 2022, 5(4): e229244. PMID: 35486403. PMCID: PMC9055453. DOI: 10.1001/jamanetworkopen.2022.9244.
Aringer M, Costenbader K, Daikh D, et al. 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus[J]. Arthritis Rheumatol, 2019, 71(9): 1400-1412. PMID: 31385462. PMCID: PMC6827566. DOI: 10.1002/art.40930.
Stockfelt M, Larsson G, Engstr?m H, et al. Activated low-density granulocytes in peripheral and intervillous blood and neutrophil inflammation in placentas from SLE pregnancies[J]. Lupus Sci Med, 2021, 8(1): e000463. PMID: 33685997. PMCID: PMC7942245. DOI: 10.1136/lupus-2020-000463.
Vinet é, Pineau CA, Scott S, et al. Increased congenital heart defects in children born to women with systemic lupus erythematosus: results from the offspring of systemic lupus erythematosus mothers registry study[J]. Circulation, 2015, 131(2): 149-156. PMID: 25355915. DOI: 10.1161/CIRCULATIONAHA.114.010027.
Sandoval-Valdez D, Silveira LH, Rodríguez E. Cardiovascular risk in the postnatal life of children born to women with systemic lupus erythematous[J]. Arch Cardiol Mex, 2022, 92(4): 522-529. PMID: 35358379. PMCID: PMC9681509. DOI: 10.24875/ACM.21000063.
Yousef Yengej FA, van Royen-Kerkhof A, Derksen RHWM, et al. The development of offspring from mothers with systemic lupus erythematosus. A systematic review[J]. Autoimmun Rev, 2017, 16(7): 701-711. PMID: 28479488. DOI: 10.1016/j.autrev.2017.05.005.
Davidov D, Sheiner E, Wainstock T, et al. Maternal systemic lupus erythematosus (SLE) high risk for preterm delivery and not for long-term neurological morbidity of the offspring[J]. J Clin Med, 2021, 10(13): 2952. PMID: 34209187. PMCID: PMC8269125. DOI: 10.3390/jcm10132952.
Grigorenko EL, Compton DL, Fuchs LS, et al. Understanding, educating, and supporting children with specific learning disabilities: 50 years of science and practice[J]. Am Psychol, 2020, 75(1): 37-51. PMID: 31081650. PMCID: PMC6851403. DOI: 10.1037/amp0000452.
Ross G, Sammaritano L, Nass R, et al. Effects of mothers' autoimmune disease during pregnancy on learning disabilities and hand preference in their children[J]. Arch Pediatr Adolesc Med, 2003, 157(4): 397-402. PMID: 12695238. DOI: 10.1001/archpedi.157.4.397.
Neri F, Chimini L, Bonomi F, et al. Neuropsychological development of children born to patients with systemic lupus erythematosus[J]. Lupus, 2004, 13(10): 805-811. PMID: 15540514. DOI: 10.1191/0961203304lu2018oa.
Knudsen SS, Simard JF, Knudsen JS, et al. Systemic lupus erythematosus during pregnancy is not associated with school performance in offspring: a Danish population-based study[J]. Lupus, 2021, 30(2): 228-237. PMID: 33197369. DOI: 10.1177/0961203320973076.
Tambyraja SR, Farquharson K, Justice LM. Phonological processing skills in children with speech sound disorder: a multiple case study approach[J]. Int J Lang Commun Disord, 2023, 58(1): 15-27. PMID: 36039861. DOI: 10.1111/1460-6984.12764.
Marder W, Romero VC, Ganser MA, et al. Increased usage of special educational services by children born to mothers with systemic lupus erythematosus and antiphospholipid antibodies[J]. Lupus Sci Med, 2014, 1(1): e000034. PMID: 25379194. PMCID: PMC4213825. DOI: 10.1136/lupus-2014-000034.
Marder W, Ganser MA, Romero V, et al. In utero azathioprine exposure and increased utilization of special educational services in children born to mothers with systemic lupus erythematosus[J]. Arthritis Care Res (Hoboken), 2013, 65(5): 759-766. PMID: 23139238. PMCID: PMC3572294. DOI: 10.1002/acr.21888.
Herscu P, Handen BL, Arnold LE, et al. The Sofia study: negative multi-center study of low dose fluoxetine on repetitive behaviors in children and adolescents with autistic disorder[J]. J Autism Dev Disord, 2020, 50(9): 3233-3244. PMID: 31267292. DOI: 10.1007/s10803-019-04120-y.
Gengoux GW, Schwartzman JM, Millan ME, et al. Enhancing social initiations using naturalistic behavioral intervention: outcomes from a randomized controlled trial for children with autism[J]. J Autism Dev Disord, 2021, 51(10): 3547-3563. PMID: 33387236. DOI: 10.1007/s10803-020-04787-8.
Turgeon S, Lanovaz MJ, Dufour MM. Effects of an interactive web training to support parents in reducing challenging behaviors in children with autism[J]. Behav Modif, 2021, 45(5): 769-796. PMID: 32248698. DOI: 10.1177/0145445520915671.
Vinet é, Pineau CA, Clarke AE, et al. Increased risk of autism spectrum disorders in children born to women with systemic lupus erythematosus: results from a large population-based cohort[J]. Arthritis Rheumatol, 2015, 67(12): 3201-3208. PMID: 26315754. DOI: 10.1002/art.39320.
Tsai PH, Yu KH, Chou IJ, et al. Risk of autism spectrum disorder in children born to mothers with systemic lupus erythematosus and rheumatoid arthritis in Taiwan[J]. Joint Bone Spine, 2018, 85(5): 599-603. PMID: 29183859. DOI: 10.1016/j.jbspin.2017.11.005.
Zhu Z, Tang S, Deng X, et al. Maternal systemic lupus erythematosus, rheumatoid arthritis, and risk for autism spectrum disorders in offspring: a meta-analysis[J]. J Autism Dev Disord, 2020, 50(8): 2852-2859. PMID: 32034648. DOI: 10.1007/s10803-020-04400-y.
Kollins SH, DeLoss DJ, Ca?adas E, et al. A novel digital intervention for actively reducing severity of paediatric ADHD (STARS-ADHD): a randomised controlled trial[J]. Lancet Digit Health, 2020, 2(4): e168-e178. PMID: 33334505. DOI: 10.1016/S2589-7500(20)30017-0.
Crouzet L, Gramond A, Suehs C, et al. Third-generation cognitive behavioral therapy versus treatment-as-usual for attention deficit and hyperactivity disorder: a multicenter randomized controlled trial[J]. Trials, 2022, 23(1): 83. PMID: 35090544. PMCID: PMC8796622. DOI: 10.1186/s13063-021-05983-2.
Huang XX, Ou P, Qian QF, et al. Long-term effectiveness of behavioural intervention in preschool children with attention deficit hyperactivity disorder in Southeast China: a randomized controlled trial[J]. BMC Pediatr, 2021, 21(1): 561. PMID: 34893038. PMCID: PMC8662873. DOI: 10.1186/s12887-021-03046-8.
Di Lorenzo R, Balducci J, Poppi C, et al. Children and adolescents with ADHD followed up to adulthood: a systematic review of long-term outcomes[J]. Acta Neuropsychiatr, 2021, 33(6): 283-298. PMID: 34384511. DOI: 10.1017/neu.2021.23.
Lazzaroni MG, Andreoli L, Crisafulli F, et al. Neuropsychiatric outcome of children born to women with systemic lupus erythematosus and exposed in utero to azathioprine: a case-control study[J]. Front Pharmacol, 2020, 11: 613239. PMID: 33390998. PMCID: PMC7772243. DOI: 10.3389/fphar.2020.613239.
Couture J, Ben-Shoshan M, Pineau CA, et al. Risk of allergic conditions in children born to women with systemic lupus erythematosus[J]. Arthritis Care Res (Hoboken), 2018, 70(2): 315-319. PMID: 28382783. DOI: 10.1002/acr.23251.
Rossides M, Nguyen C, Arkema EV, et al. Asthma in children of mothers with systemic lupus erythematosus and the role of preterm birth[J]. Arthritis Care Res (Hoboken), 2018, 70(8): 1269-1274. PMID: 29125902. PMCID: PMC5945344. DOI: 10.1002/acr.23472.
Couture J, Bernatsky S, Scott S, et al. Brief report: risk of childhood rheumatic and nonrheumatic autoimmune diseases in children born to women with systemic lupus erythematosus[J]. Arthritis Rheumatol, 2018, 70(11): 1796-1800. PMID: 29790298. DOI: 10.1002/art.40570.
Wu CH, Chen CA, Lin SH, et al. Increased risk of early-onset childhood systemic lupus erythematosus for children born to affected parents: a nationwide child-parent cohort study[J]. Front Immunol, 2022, 13: 966809. PMID: 36131920. PMCID: PMC9483159. DOI: 10.3389/fimmu.2022.966809.
