Research advances in the etiology and pathogenesis of immunoglobulin A vasculitis
JIANATI Reaila, LIU Xi-Xi, ZHU Xue-Jun
Department of Hematology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China (Zhu X-J, Email: zhuxuejun@njucm.edu.cn)
Abstract：Immunoglobulin A vasculitis (IgAV), also known as Henoch-Sch?nlein purpura, has complex etiology and pathogenesis which have not been fully clarified. The latest research shows that SARS-CoV-2 and related vaccines, human papilloma vaccine, and certain biological agents can also induce IgAV. Most studies believe that the formation of galactose-deficient IgA1 (Gd-IgA1) and Gd-IgA1-containing immune complex plays a crucial role in the pathogenesis of IgAV. It is hypothesized that the pathogenesis of IgAV is associated with the binding of IgA1 to anti-endothelial cell antibodies. In addition, genetics also constitutes a major focus of IgAV research. This article reviews the new advances in the etiology of IgAV and summarizes the role of Gd-IgA1, Gd-IgA1-containing immune complex, anti-endothelial antibody, IgA1 conjugates, T lymphocyte immunity, and genetic factors in the pathogenesis of IgAV.
JIANATI Reaila,LIU Xi-Xi,ZHU Xue-Jun. Research advances in the etiology and pathogenesis of immunoglobulin A vasculitis[J]. CJCP, 2023, 25(12): 1287-1292.
