Abstract：B-cell activating factor (BAFF), a critical regulator of B cells, is involved in various autoimmune diseases. Inflammatory bowel disease (IBD) is a group of chronic and recurrent intestinal inflammatory disorders with unclear etiology, and its global incidence has been increasing in recent years. Abnormal immune responses triggered by multiple factors are closely related to the pathogenesis of IBD. Previous studies have confirmed the association of B-cell abnormal activation and increased production of autoantibodies with the development of ulcerative colitis. However, the involvement of BAFF in the mechanisms of IBD remains unclear. This review summarizes the potential role of BAFF in the pathogenesis of IBD and provides an overview of targeted therapies on BAFF in IBD, aiming to contribute insights for targeted treatments of IBD.
LI Lin,LIU Hai-Yan,WANG Li-Jun. Research advances on B-cell activating factor and its targeted agents in inflammatory bowel disease[J]. CJCP, 2024, 26(3): 315-320.
Cornelis R, Chang HD, Radbruch A. Keeping up with the stress of antibody production: BAFF and APRIL maintain memory plasma cells[J]. Curr Opin Immunol, 2021, 71: 97-102. PMID: 34303157. DOI: 10.1016/j.coi.2021.06.012.
Shaul ME, Zlotnik A, Tidhar E, et al. Tumor-associated neutrophils drive B-cell recruitment and their differentiation to plasma cells[J]. Cancer Immunol Res, 2021, 9(7): 811-824. PMID: 33906865. DOI: 10.1158/2326-6066.CIR-20-0839.
Giordano D, Kuley R, Draves KE, et al. BAFF produced by neutrophils and dendritic cells is regulated differently and has distinct roles in antibody responses and protective immunity against West Nile virus[J]. J Immunol, 2020, 204(6): 1508-1520. PMID: 32034064. PMCID: PMC7357242. DOI: 10.4049/jimmunol.1901120.
Schuh E, Musumeci A, Thaler FS, et al. Human plasmacytoid dendritic cells display and shed B cell maturation antigen upon TLR engagement[J]. J Immunol, 2017, 198(8): 3081-3088. PMID: 28283566. DOI: 10.4049/jimmunol.1601746.
Hu S, Wang R, Zhang M, et al. BAFF promotes T cell activation through the BAFF-BAFF-R-PI3K-Akt signaling pathway[J]. Biomed Pharmacother, 2019, 114: 108796. PMID: 30921706. DOI: 10.1016/j.biopha.2019.108796.
Salazar-Camarena DC, Ortíz-Lazareno P, Marín-Rosales M, et al. BAFF-R and TACI expression on CD3+ T cells: interplay among BAFF, APRIL and T helper cytokines profile in systemic lupus erythematosus[J]. Cytokine, 2019, 114: 115-127. PMID: 30467093. DOI: 10.1016/j.cyto.2018.11.008.
Mackay F, Schneider P. TACI, an enigmatic BAFF/APRIL receptor, with new unappreciated biochemical and biological properties[J]. Cytokine Growth Factor Rev, 2008, 19(3-4): 263-276. PMID: 18514565. DOI: 10.1016/j.cytogfr.2008.04.006.
Wang QT, Ma YK, Huang B, et al. Effect of rhTACI-Ig fusion protein on antigen-specific T cell responses from keyhole limpet haemocyanin challenged mice[J]. Mol Immunol, 2011, 49(1-2): 380-386. PMID: 21967866. DOI: 10.1016/j.molimm.2011.09.007.
Fodor I, Serban O, Serban DE, et al. B cell-activating factor (BAFF) in children with inflammatory bowel disease[J]. Pediatr Res, 2021, 89(7): 1798-1803. PMID: 32937648. DOI: 10.1038/s41390-020-01155-1.
Fu Y, Wang L, Xie C, et al. Comparison of non-invasive biomarkers faecal BAFF, calprotectin and FOBT in discriminating IBS from IBD and evaluation of intestinal inflammation[J]. Sci Rep, 2017, 7(1): 2669. PMID: 28572616. PMCID: PMC5453945. DOI: 10.1038/s41598-017-02835-5.
Itotagawa E, Tomofuji Y, Kato Y, et al. SLE stratification based on BAFF and IFN-I bioactivity for biologics and implications of BAFF produced by glomeruli in lupus nephritis[J]. Rheumatology (Oxford), 2023, 62(5): 1988-1997. PMID: 36094336. PMCID: PMC10152287. DOI: 10.1093/rheumatology/keac528.
Nascimento M, Huot-Marchand S, Gombault A, et al. B-cell activating factor secreted by neutrophils is a critical player in lung inflammation to cigarette smoke exposure[J]. Front Immunol, 2020, 11: 1622. PMID: 32849550. PMCID: PMC7405926. DOI: 10.3389/fimmu.2020.01622.
Manetta J, Bina H, Ryan P, et al. Generation and characterization of tabalumab, a human monoclonal antibody that neutralizes both soluble and membrane-bound B-cell activating factor[J]. J Inflamm Res, 2014, 7: 121-131. PMID: 25258549. PMCID: PMC4173659. DOI: 10.2147/JIR.S67751.
Riccobene TA, Miceli RC, Lincoln C, et al. Rapid and specific targeting of 125I-labeled B lymphocyte stimulator to lymphoid tissues and B cell tumors in mice[J]. J Nucl Med, 2003, 44(3): 422-433. PMID: 12621010.
