PDF(1246 KB)
Reference ranges of platelet and related parameters within 24 hours after birth in preterm infants with different gestational ages
WANG You-Ping, FENG Jin-Nan, LI Zhen-Yu, LYU Xiao-Ming, JIANG Qing-Lei, WU Hui
Chinese Journal of Contemporary Pediatrics ›› 2020, Vol. 22 ›› Issue (7) : 696-700.
PDF(1246 KB)
PDF(1246 KB)
Reference ranges of platelet and related parameters within 24 hours after birth in preterm infants with different gestational ages
Objective To study the reference ranges of platelet and related parameters within 24 hours after birth in preterm infants with different gestational ages. Methods According to the inclusion and exclusion criteria, a retrospective analysis was performed for the chart review data of 1 070 preterm infants with a gestational age of 23-36+6 weeks who were admitted to the neonatal intensive care unit from January to December in 2018. The reference ranges of platelet parameters were calculated for the preterm infants within 24 hours after birth. Results There were no significant differences in platelet count (PLT) and plateletcrit (PCT) among the preterm infants with different gestational ages (P > 0.05). The late preterm infants (34-36+6 weeks; n=667) had significantly lower mean platelet volume (MPV) and platelet distribution width (PDW) than the extremely preterm infants (23-27+6 weeks; n=36) and the early preterm infants (28-33+6 weeks; n=367) (P < 0.05). There were no significant differences in these platelet parameters between the preterm infants with different sexes (P > 0.05). The reference ranges of platelet parameters in preterm infants were calculated based on gestational age. The reference ranges of PLT and PCT were (92-376)×109/L and 0.1%-0.394% respectively, for the preterm infants with a gestational age of 23-36+6 weeks. The reference ranges of MPV and PDW were 9.208-12.172 fl and 8.390%-16.407% respectively, for the preterm infants with a gestational age of 23-36+6 weeks; the reference ranges of MPV and PDW were 9.19-11.95 fl and 9.046%-15.116% respectively, for the preterm infants with a gestational age of 34-36+6 weeks. Conclusions The MPV and PDW of preterm infants with different gestational age are different within 24 hours after birth, and it is more helpful for clinical practice to formulate the reference range of MPV and PDW according to gestational age.
[1] Huang HS, Chang HH. Platelets in inflammation and immune modulations:functions beyond hemostasis[J]. Arch Immunol Ther Exp (Warsz), 2012, 60(6):443-451.
[2] Katz JN, Kolappa KP, Becker RC. Beyond thrombosis:the versatile platelet in critical illness[J]. Chest, 2011, 139(3):658-668.
[3] Leslie M. Cell biology. Beyond clotting:the powers of platelets[J]. Science, 2010, 328(5978):562-564.
[4] McPherson RJ, Juul S. Patterns of thrombocytosis and thrombocytopenia in hospitalized neonates[J]. J Perinatol, 2005, 25(3):166-172.
[5] Henry E, Walker D, Wiedmeier SE, et al. Hematological abnormalities during the first week of life among neonates with Down syndrome:data from a multihospital healthcare system[J]. Am J Med Genet A, 2007, 143A(1):42-50.
[6] Mantadakis E, Tsalkidis A, Chatzimichael A. Thrombocytosis in childhood[J]. Indian Pediatr, 2008, 45(8):669-677.
[7] Wiedmeier SE, Henry E, Sola-Visner MC, et al. Platelet reference ranges for neonates, defined using data from over 47,000 patients in a multihospital healthcare system[J]. J Perinatol, 2009, 29(2):130-136.
[8] 邵肖梅, 叶鸿瑁, 丘小汕. 实用新生儿学[M]. 第5版. 北京:人民卫生出版社, 2019:57, 1070.
[9] Demirel G, Y?lmaz A, Vatansever B, et al. Is high platelet distribution width in the first hours of life can predict hemodynamically significant patent ductus arteriosus in preterm newborns?[J]. J Matern Fetal Neonatal Med, 2020, 33(12):2049-2053.
[10] Dundar B, Dincgez Cakmak B, Ozgen G, et al. Platelet indices in preterm premature rupture of membranes and their relation with adverse neonatal outcomes[J]. J Obstet Gynaecol Res, 2018, 44(1):67-73.
[11] Shaaban HA, Safwat N. Mean platelet volume in preterm:a predictor of early onset neonatal sepsis[J]. J Matern Fetal Neonatal Med, 2020, 33(2):206-211.
[12] Chen CY, Essien MD, Johnson AJ, et al. Use of mean platelet volume in the assessment of intrauterine infection in newborns with combined thrombocytopenia and leukopenia at birth[J]. J Matern Fetal Neonatal Med, 2019. DOI:10.1080/14767058.2019.1608174. Online ahead of print.
[13] Alicja W, Agnieszka P, Piotr L, et al. Platelet indices in late preterm newborns[J]. J Matern Fetal Neonatal Med, 2017, 30(14):1699-1703.
[14] Chen X, Li H, Qiu X, et al. Neonatal hematological parameters and the risk of moderate-severe bronchopulmonary dysplasia in extremely premature infants[J]. BMC Pediatr, 2019, 19(1):138.
[15] 王鸿利. 广泛开展血小板检测及其临床应用[J]. 中华医学检验杂志, 1996, 19(3):137-138.
[16] Olukman O, Ozdemir R, Karadeniz C, et al. Is there a relationship between platelet parameters and patency of ductus arteriosus in preterm infants?[J]. Blood Coagul Fibrinolysis, 2017, 28(1):8-13.
[17] Van den Hof MC, Nicolaides KH. Platelet count in normal, small, and anemic fetuses[J]. Am J Obstet Gynecol, 1990, 162(3):735-739.
[18] Sitaru AG, Holzhauer S, Speer CP, et al. Neonatal platelets from cord blood and peripheral blood[J]. Platelets, 2005, 16(3-4):203-210.
[19] Pietrucha T, Wojciechowski T, Greger J, et al. Differentiated reactivity of whole blood neonatal platelets to various agonists[J]. Platelets, 2001, 12(2):99-107.
[20] Hézard N, Potron G, Schlegel N, et al. Unexpected persistence of platelet hyporeactivity beyond the neonatal period:a flow cytometric study in neonates, infants and older children[J]. Thromb Haemost, 2003, 90(1):116-123.
[21] Andres O, Schulze H, Speer CP. Platelets in neonates:central mediators in haemostasis, antimicrobial defence and inflammation[J]. Thromb Haemost, 2015, 113(1):3-12.
[22] Saving KL, Jennings DE, Aldag JC, et al. Platelet ultrastructure of high-risk premature infants[J]. Thromb Res, 1994, 73(6):371-384.
