PDF(1648 KB)
Asymptomatic SARS-CoV-2 infection in children: a clinical analysis of 20 cases
CHEN Jun, WANG Xian-Feng, ZHANG Pei-Fa
Chinese Journal of Contemporary Pediatrics ›› 2020, Vol. 22 ›› Issue (5) : 414-418.
PDF(1648 KB)
PDF(1648 KB)
Asymptomatic SARS-CoV-2 infection in children: a clinical analysis of 20 cases
Objective To study the clinical and epidemiological features of children with asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods The clinical data of 20 children who were diagnosed with asymptomatic SARS-CoV-2 infection from January 20 to March 4, 2020 were analyzed. Results Among the 20 children, there were 7 boys (35%) and 13 girls (65%), aged 8 months to 14 years (mean 8±5 years). All these children had no clinical manifestations and attended the hospital for an epidemiological history of SARS-CoV-2. Nineteen children were shown with family aggregation of SARS-CoV-2 infection. Nasopharyngeal swabs were PCR-positive for SARS-CoV-2 in all 20 children. There were 4 children (20%) of mild type, 16 children (80%) of common type, and no children of severe type or critical type. The mean peripheral blood leukocyte count was (6.8±3.5)×109/L, and 7 children had an abnormal peripheral blood leukocyte count, with an increase in 5 children and a reduction in 2 children. One child had a decreased absolute value of lymphocytes (0.87×109/L), 3 children had an increased erythrocyte sedimentation rate (20-42 mm/h), 7 children had an increased lactate dehydrogenase level (> 400 U/L), and 4 children had an increased blood lactate level (> 1.6 mmol/L). Chest CT showed single or multiple small nodule shadows, patchy shadows, and ground-glass shadows in the middle or lateral lobe of lungs or under the pleura in 13 children. Conclusions Pediatric cases of asymptomatic SARS-CoV-2 infection mostly occur with family aggregation. Most of the children with asymptomatic infection have no obvious abnormalities in blood routine and other laboratory tests. Changes in chest CT scan can be used as an aid for early diagnosis of asymptomatic infection in children.
SARS-CoV-2 / Asymptomatic infection / Family aggregation / Child
[1] Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019[J]. N Engl J Med, 2020, 382(8):727-733.
[2] World Health Organization. Home care for patients with suspected novel coronavirus (nCoV) infection presenting with mild symptoms and management of contacts[EB/OL]. (2020-03-17)[2020-03-20]. https://www.who.int/publications-detail/home-care-for-patients-with-suspected-novel-coronavirus-(ncov)-infection-presenting-with-mild-symptoms-and-management-of-contacts.
[3] 国家卫生健康委办公厅, 国家中医药管理局办公室. 新型冠状病毒感染的肺炎诊疗方案(试行第五版)[EB/OL]. (2020-02-05)[2020-02-05]. http://www.nhc.gov.cn/yzygj/s7653p/202002/3b09b894ac9b4204a79db5b8912d4440.shtml.
[4] 中国疾病预防控制中心. 新型冠状病毒防控指南(第一版)[EB/OL]. (2020-02-01)[2020-02-03]. http://www.nhc.gov.cn/jkj/s3578/202002/34c1c337ef874fa58af58a1717005389.shtml.
[5] 国家卫生健康委办公厅, 国家中医药管理局办公室. 新型冠状病毒肺炎诊疗方案(试行第六版)[EB/OL]. (2020-02-19)[2020-02-19]. http://www.nhc.gov.cn/yzygj/s7653p/202002/8334a8326dd94d329df351d7da8aefc2.shtml.
[6] 陈志敏, 傅君芬, 舒强, 等. 儿童2019冠状病毒病(COVID-19)诊疗指南(第二版)[J]. 浙江大学学报(医学版), 2020. DOI:10.3785/j.issn.1008-9292.2020.02.01. 网络预发表.
[7] 李仲智, 申昆玲, 魏新苗, 等. 18例儿童严重急性呼吸综合征临床分析[J]. 中华儿科杂志, 2003, 41(8):574-577.
[8] 杨永弘. 关注严重急性呼吸综合征[J].中华儿科杂志, 2003, 41(6):401-402.
[9] 曾其毅, 刘丽, 曾华松, 等. 广州地区33例儿童严重急性呼吸综合征临床特点和治疗转归[J]. 中华儿科杂志, 2003, 41(6):408-412.
[10] Thabet F, Chehab M, Bafaqih H, et al. Middle East respiratory syndrome coronavirus in children[J]. Saudi Med J, 2015, 36(4):484-486.
[11] 中华医学会儿科学分会, 中华儿科杂志编辑委员会. 儿童2019新型冠状病毒感染的诊断与防治建议(试行第一版)[J]. 中华儿科杂志, 2020, 58(3):169-174.
[12] 王劲, 王丹, 陈国策, 等. 以消化道症状为首发表现的新生儿SARS-CoV-2感染1例[J]. 中国当代儿科杂志, 2020, 22(3):211-214.
[13] Chung M, Bernheim A, Mei X, et al. CT imaging features of 2019 novel coronavirus (2019-nCoV)[J]. Radiology, 2020, 295(1):202-207.
[14] Lei J, Li J, Li X, et al. CT imaging of the 2019 novel coronavirus (2019-nCoV) pneumonia[J]. Radiology, 2020, 295(1):18.
[15] 中华医学会放射学分会. 新型冠状病毒肺炎的放射学诊断:中华医学会放射学分会专家推荐意见(第一版)[J]. 中华放射学杂志, 2020, 54(4):279-285.
