
Effect of pertussis vaccination on clinical manifestations of infants and young children with pertussis
TANG Qi-Qin, GAN Chuan, WU Xiao-Ying, XU Hong-Mei, ZHANG Zhen-Zhen
Chinese Journal of Contemporary Pediatrics ›› 2021, Vol. 23 ›› Issue (2) : 138-142.
Effect of pertussis vaccination on clinical manifestations of infants and young children with pertussis
Objective To study the effect of pertussis vaccination on the clinical manifestations of infants and young children with pertussis. Methods A retrospective analysis was performed to investigate the differences in clinical manifestations and peripheral blood cell levels between pertussis children with different pertussis vaccination status. Results A total of 1 083 children with pertussisat at age of <3 years were enrolled, with 551 children in the unvaccinated group and 532 in the vaccinated group. Of all the children, 392 had an age of onset of < 3 months (372 were unvaccinated and 20 were vaccinated) and 691 children had an age of onset of ≥ 3 months (179 were unvaccinated and 512 were vaccinated). Compared with the vaccinated group, the unvaccinated group had a longer length of hospital stay and a higher incidence rate of respiratory failure (P < 0.05). Among the children ≥ 3 months of age, the incidence of severe pneumonia in the unvaccinated group was higher than that in the vaccinated group (P < 0.05), and the incidence of severe pneumonia was the highest in the unvaccinated group (10.6%) and the lowest in the 4-dose vaccination group (1.2%). Among the 101 patients with severe pneumonia, 80 (79.2%) were observed in the unvaccinated group and only 21 (20.8%) in the four different doses vaccination groups. For the children with an age of onset of ≥ 3 months, the unvaccinated group had higher white blood cell count, absolute value of lymphocytes, and platelet count than the vaccinated group (P < 0.05). Conclusions Pertussis vaccination can reduce the incidence of severe pneumonia and respiratory failure and alleviate the severity of respiratory complications in infants and young children with pertussis.
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