PDF(1944 KB)
Recurrent vulvar rashes in a girl aged 22 months for more than half a year
I Ke-Yao, TANG Jian-Ping, JIANG Yan-Ling, TAN Xin, WEI Zhu, WEN Rong, ZHOU Bin
Chinese Journal of Contemporary Pediatrics ›› 2021, Vol. 23 ›› Issue (1) : 98-102.
PDF(1944 KB)
PDF(1944 KB)
Recurrent vulvar rashes in a girl aged 22 months for more than half a year
A girl, aged 22 months, attended the hospital due to recurrent vulvar rashes for more than half a year. Skin biopsy showed Langerhans cell histiocytosis, and evaluation of systemic conditions showed no systemic involvement. Therefore, the girl was diagnosed with Langerhans cell histiocytosis (skin type). In conclusion, for rashes on the vulva alone, if there are no specific clinical manifestations, the possibility of Langerhans cell histiocytosis should be considered after molluscum contagiosum, sexually transmitted diseases, and Fordyce disease are excluded.
[1] 马琳. 儿童皮肤病学[M]. 北京:人民卫生出版社, 2014:115-122.
[2] 赵辨. 临床皮肤病学[M]. 3版. 南京:江苏科学技术出版社, 2001:1561.
[3] Zamora AB, Simón MP, Sánchez AT, et al. Adult colloid milium. An underdiagnosed and difficult to treat entity[J]. Rev Med Hosp Gen Méx, 2016, 79(1):21-25.
[4] 王迎林, 王泽民, 赵子娥, 等. 外阴部皮脂腺异位症20例[J]. 中华皮肤科杂志, 1997, 30(3):47-48.
[5] Fernandez Flores A, Mallo S. Langerhans cell histiocytosis of vulva[J]. Dermatol Online J, 2006, 12(1):15.
[6] 周勐, 王彦, 杨秀莉. 单纯外阴受累的朗格汉斯细胞组织细胞增生症一例[J]. 中华皮肤科杂志, 2018, 51(7):538.
[7] 陈超超, 杨汝斌, 黄玲, 等. 单纯外阴受累的朗格汉斯细胞组织细胞增生症一例[J]. 中华皮肤科杂志, 2016, 49(3):211.
[8] 王小坡, 熊竞舒, 温斯健, 等. 外阴朗格汉斯细胞组织细胞增生症一例[J]. 中华皮肤科杂志, 2017, 50(6):452.
[9] Pan Z, Sharma S, Sharma P. Primary Langerhans cell histiocytosis of the vulva:report of a case and brief review of the literature[J]. Indian J Pathol Microbiol, 2009, 52(1):65-68.
[10] Emile JF, Abla O, Fraitag S, et al. Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages[J]. Blood, 2016, 127(22):2672-2681.
[11] Zinn DJ, Chakraborty R, Allen CE. Langerhans cell histiocytosis:emerging insights and clinical implications[J]. Oncology (Williston Park), 2016, 30(2):122-132.
[12] DiCaprio MR, Roberts TT. Diagnosis and management of Langerhans cell histiocytosis[J]. J Am Acad Orthop Surg, 2014, 22(10):643-652.
[13] Chang JC, Blake DG, Leung BV, et al. Langerhans cell histiocytosis associated with lichen sclerosus of the vulva:case report and review of the literature[J]. J Cutan Pathol, 2013, 40(2):279-283.
[14] Badalian-Very G, Vergilio JA, Degar BA, et al. Recurrent BRAF mutations in Langerhans cell histiocytosis[J]. Blood, 2010, 116(11):1919-1923.
[15] Kurt S, Canda MT, Kopuz A, et al. Diagnosis of primary Langerhans cell histiocytosis of the vulva in a postmenopausal woman[J]. Case Rep Obstet Gynecol, 2013, 2013:962670.
[16] 周云, 刘秋玲. 朗格汉斯细胞组织细胞增生症的发病机制及诊治进展[J]. 中华灾害救援医学, 2017, 5(2):106-110.
[17] 周燕华, 梁伶, 刘栋华. 以脐周皮损为首发表现的老年人朗格汉斯细胞组织细胞增生症1例[J]. 中国皮肤性病学杂志, 2013, 27(10):1038-1039.
[18] 陈浩, 薛燕宁, 许昌春, 等. 以肛周皮损为首发表现的成人朗格汉斯组织细胞增生症[J]. 临床皮肤科杂志, 2012, 41(1):22-24.
[19] Subramaniyan R, Ramachandran R, Rajangam G, et al. Purely cutaneous Langerhans cell histiocytosis presenting as an ulcer on the chin in an elderly man successfully treated with thalidomide[J]. Indian Dermatol Online J, 2015, 6(6):407-409.
[20] Ishigaki H, Hatta N, Yamada M, et al. Localised vulva Langerhans cell histiocytosis[J]. Eur J Dermatol, 2004, 14(6):412-414.
[21] Venizelos ID, Mandala E, Tatsiou ZA, et al. Primary Langerhans cell histiocytosis of the vulva[J]. Int J Gynecol Pathol, 2006, 25(1):48-51.
