PDF(1370 KB)
Clinical features of children with Mycoplasma pneumoniae pneumonia and peripheral lymphocytopenia
PENG Li, ZHONG Li-Li, HUANG Zhen, LI Yan, ZHANG Bing
Chinese Journal of Contemporary Pediatrics ›› 2021, Vol. 23 ›› Issue (1) : 74-77.
PDF(1370 KB)
PDF(1370 KB)
Clinical features of children with Mycoplasma pneumoniae pneumonia and peripheral lymphocytopenia
Objective To study the clinical features of children with Mycoplasma pneumoniae pneumonia (MPP) and peripheral lymphocytopenia. Methods A total of 310 MPP children who were hospitalized and underwent bronchoalveolar lavage from June 2018 to June 2019 were enrolled and divided into two groups: simple MPP group with 241 children (without peripheral lymphocytopenia) and MPP + peripheral lymphocytopenia group with 69 children. The two groups were compared in terms of clinical data and treatment outcome. Results Compared with the simple MPP group, the MPP + peripheral lymphocytopenia group had significantly longer duration of fever and length of hospital stay and significant increases in C-reactive protein, lactate dehydrogenase, and Mycoplasma pneumoniae DNA copies in bronchoalveolar lavage fluid (P < 0.05). Compared with the simple MPP group, the MPP + peripheral lymphocytopenia group had significantly higher incidence rates of intrapulmonary consolidation, extrapulmonary complications, and serious lesions under bronchoscopy (erosion or sputum bolt) and a significantly higher proportion of patients with severe MPP (P < 0.05). Conclusions Children with MPP and peripheral lymphocytopenia tend to have more severe immunologic injury. Peripheral blood lymphocyte count may be used to evaluate the severity of MPP.
[1] Leung AKC, Wong AHC, Hon KL. Community-acquired pneumonia in children[J]. Recent Pat Inflamm Allergy Drug Discov, 2018, 12(2):136-144.
[2] Bajantri B, Venkatram S, Diaz-Fuentes G. Mycoplasma pneumoniae:a potentially severe infection[J]. J Clin Med Res, 2018, 10(7):535-544.
[3] Saraya T, Kurai D, Nakagaki K, et al. Novel aspects on the pathogenesis of Mycoplasma pneumoniae pneumonia and therapeutic implications[J]. Front Microbiol, 2014, 5:410.
[4] Guo L, Liu F, Lu MP, et al. Increased T cell activation in BALF from children with Mycoplasma pneumoniae pneumonia[J]. Pediatr Pulmonol, 2015, 50(8):814-819.
[5] 中华医学会儿科学分会呼吸学组, 《 中华儿科杂志》 编辑委员会. 儿童社区获得性肺炎管理指南(2013修订)(上)[J]. 中华儿科杂志, 2013, 51(10):745-752.
[6] 李影林. 中华医学检验全书(上卷)[M]. 北京:人民卫生出版社, 1996:200-201.
[7] Saraya T. Mycoplasma pneumoniae infection:basics[J]. J Gen Fam Med, 2017, 18(3):118-125.
[8] Bodhankar S, Sun X, Woolard MD, et al. Interferon gamma and interleukin 4 have contrasting effects on immunopathology and the development of protective adaptive immunity against Mycoplasma respiratory disease[J]. J Infect Dis, 2010, 202(1):39-51.
[9] 李娜, 穆亚平, 陈静, 等. 淋巴细胞亚群绝对计数对儿童难治性肺炎支原体肺炎的早期预测作用[J]. 中国当代儿科杂志, 2019, 21(6):511-516.
[10] Bajantri B, Toolsie O, Venkatram S, et al. Mycoplasma pneumoniae pneumonia:walking pneumonia can cripple the susceptible[J]. J Clin Med Res, 2018, 10(12):891-897.
[11] Obirikorang C, Quaye L, Acheampong I. Total lymphocyte count as a surrogate marker for CD4 count in resource-limited settings[J]. BMC Infect Dis, 2012, 12:128.
[12] Stebbing J, Sawleshwarkar S, Michailidis C, et al. Assessment of the efficacy of total lymphocyte counts as predictors of AIDS defining infections in HIV-1 infected people[J]. Postgrad Med J, 2005, 81(959):586-588.
[13] Zhang Y, Mei S, Zhou Y, et al. Cytokines as the good predictors of refractory Mycoplasma pneumoniae pneumonia in schoolaged children[J]. Sci Rep, 2016, 6:37037.
[14] Jeong JE, Soh JE, Kwak JH, et al. Increased procalcitonin level is a risk factor for prolonged fever in children with Mycoplasma pneumonia[J]. Korean J Pediatr, 2018, 61(8):258-263.
[15] 刘金荣, 彭芸, 杨海明, 等. 难治性肺炎支原体肺炎的表现特征和判断指标探讨[J]. 中华儿科杂志, 2012, 50(12):915-918.
