Value of fractional nitric oxide concentration in exhaled breath in assessing level of asthma control in children

XIANG Li; FU YA-Nan; LI Zhen; REN Yi-Xin; RAO Xiao-Chun

doi:10.7499/j.issn.1008-8830.2013.01.008

PDF(915 KB)

Chinese Journal of Contemporary Pediatrics ›› 2013, Vol. 15 ›› Issue (1) : 29-32. DOI: 10.7499/j.issn.1008-8830.2013.01.008

CLINICAL RESEARCH

Value of fractional nitric oxide concentration in exhaled breath in assessing level of asthma control in children

XIANG Li, FU YA-Nan, LI Zhen, REN Yi-Xin, RAO Xiao-Chun

Author information +

History +

Abstract

OBJECTIVE: To investigate the value of fractional nitric oxide concentration in exhaled breath (FeNO) in assessing the level of asthma control in children. METHODS: A total of 226 asthmatic children were divided into controlled asthma (n= 86), partially controlled asthma (n=63), and uncontrolled asthma groups (n=77). Ninety healthy children were enrolled as controls. FeNO was measured for both asthmatic and healthy children using the Swedish-designed NIOX system. RESULTS: The control group had an FeNO of 14±6 ppb, the controlled asthma group had an FeNO of 29±26 ppb, the partially controlled asthma group had an FeNO of 32±30 ppb, and the uncontrolled asthma group had an FeNO of 40±32 ppb. The three asthma groups showed significantly higher FeNO than the control group (P<0.05). The uncontrolled asthma group showed significantly higher FeNO than the controlled asthma group (P<0.05), but there were no significant differences in FeNO between the partially controlled and uncontrolled asthma groups and between the partially controlled and controlled asthma groups (P>0.05). CONCLUSIONS: Asthmatic children have significantly higher FeNO than healthy children, and FeNO is correlated with the level of asthma control.

Key words

Asthma / Level of asthma control / Fractional nitric oxide concentration in exhaled breath / Child

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

XIANG Li, FU YA-Nan, LI Zhen, REN Yi-Xin, RAO Xiao-Chun. Value of fractional nitric oxide concentration in exhaled breath in assessing level of asthma control in children[J]. Chinese Journal of Contemporary Pediatrics. 2013, 15(1): 29-32 https://doi.org/10.7499/j.issn.1008-8830.2013.01.008

References

［1］Dweik RA, Boggs PB, Erzurum SC, Irvin CG, Leigh MW, Lundberg JO, et al. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications［J］. Am J Respir Crit Care Med, 2011, 184(5): 602-615.

［2］Global Initiative for Asthma (GINA). Global strategy for asthma management and prevention［EB/OL］. Updated 2011. URL: http://www.ginasthma.org.

［3］中华医学会儿科分会呼吸学组，《中华儿科杂志》编辑委员会. 儿童支气管哮喘诊断与防治指南（2008年修订）［J］. 中华儿科杂志, 2008, 46(10):745-753.

［4］American Thoracic Society; European Respiratory Society. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005［J］. Am J Respir Crit Care Med, 2005, 171(8): 912-930.

［5］向莉, 李珍, 任亦欣. 体内和体外特异性变应原测定在过敏性哮喘诊断中的联合应用［J］. 实用儿科临床杂志, 2006, 21(21):1465-1467.

［6］Cobos Barroso N, Pérez-Yarza EG, Sardón Prado O, Reverté Bover C, Gartner S, Korta Murua J. Exhaled nitric oxide in children: a noninvasive marker of airway inflammation［J］. Arch Bronconeumol, 2008, 44(1): 41-51.

［7］Alving K, Weitzberg E, Lundberg JM. Increased amount of nitric oxide in exhaled air of asthmatics［J］. Eur Respir J, 1993, 6(9): 1368-1370.

［8］Jackson DJ, Virnig CM, Gangnon RE, Evans MD, Roberg KA, Anderson EL, et al. Fractional exhaled nitric oxide measurements are most closely associated with allergic sensitization in school-age children［J］. J Allergy Clin Immunol, 2009, 124(5): 949-953.

［9］向莉, 申昆玲, 张亚梅, 贺建新, 张杰, 任亦欣, 等. 3-14岁哮喘和变应性鼻炎患儿吸入性致敏原分布特征比较［J］. 中国实用儿科杂志, 2006, 21(8):581-583.

［10］Franklin PJ, Turner SW, Le Souef PN, Stick SM. Exhaled nitric oxide and asthma: complex interactions between atopy, airway responsiveness, and symptoms in a community population of children［J］. Thorax, 2003, 58(12): 1048-1052.

［11］王植嘉, 尚云晓, 单丽沈, 张晗, 侯萍, 刘芬. 哮喘儿童尘螨过敏对呼出气一氧化氮水平的影响［J］. 国际儿科学杂志, 2011, 38(5):528-529.

［12］胡肖伟, 王立波, 张灵恩, 孙波. 哮喘儿童呼出气一氧化氮水平的测定［J］. 中国当代儿科杂志, 2002, 4(1):73-75.

［13］向莉,刘世英,江载芳. 哮喘患儿呼出气一氧化氮的变化［J］. 中华儿科杂志,1998, 36(6):356-358.

［14］Verini M, Consilvio NP, Di Pillo S, Cingolani A, Spagnuolo C, Rapino D, et al. FeNO as a marker of airways inflammation: the possible implications in childhood asthma management［J］. J Allergy (Cairo), 2010. Epub 2010 May 18.

［15］Covar RA, Szefler SJ, Martin RJ, Sundstrom DA, Silkoff PE, Murphy J, et al. Relations between exhaled nitric oxide and measures of disease activity among children with mildto-moderate asthma［J］. J Pediatr, 2003, 142(5): 469-475.

［16］Foley SC, Hopkins NO, Fitzgerald MX, Donnelly SC, McLoughlin P. Airway nitric oxide output is reduced in bronchiectasis［J］. Respir Med, 2007, 101(7): 1549-1555.

［17］Shoemark A, Wilson R. Bronchial and peripheral airway nitric oxide in primary ciliary dyskinesia and bronchiectasis［J］. Respir Med, 2009, 103(5): 700-706.