Influential factors for methylphenidate treatment compliance in children with attention deficit hyperactivity disorder

DING Kai-Jing; LIU Yun-Fen; KANG Chuan-Yuan; LIU Rui-Xiang; LI Xue-Rong; WAN Shuai

doi:10.7499/j.issn.1008-8830.2013.05.006

PDF(949 KB)

Chinese Journal of Contemporary Pediatrics ›› 2013, Vol. 15 ›› Issue (5) : 343-347. DOI: 10.7499/j.issn.1008-8830.2013.05.006

CLINICAL RESEARCH

Influential factors for methylphenidate treatment compliance in children with attention deficit hyperactivity disorder

DING Kai-Jing, LIU Yun-Fen, KANG Chuan-Yuan, LIU Rui-Xiang, LI Xue-Rong, WAN Shuai

Author information +

History +

Abstract

OBJECTIVE: To investigate influential factors for the tendency to medicate and medication compliance in children with attention deficit hyperactivity disorder (ADHD). METHODS: A total of 188 children aged from 5 to 16 years, who were initially diagnosed with ADHD according to DSM-IV criteria, were included in the study. They underwent symptom assessment and cognitive function test. The compliance of methylphenidate treatment was evaluated. RESULTS: Patients with better emotional state, and fewer oppositional and hyperactive behaviors and those who had a family history of psychiatric diseases and who obtained lower scores in the number cancellation test (NCT), were more prone to medication and/or exhibited better medication compliance. Logistic regression analysis showed that fewer oppositional and hyperactive behaviors and lower NCT scores were the predictive factors for a higher tendency to medicate, and a better emotional state was the predictive factor for better medication compliance. Patients of predominantly inattentive type were more prone to medication and showed better medication compliance, as compared with those of combined type. Gender, age and symptom severity were not associated with the tendency to medicate and/or medication compliance. CONCLUSIONS: There is a need to enhance medication compliance in children with ADHD who have hyperactive, impulsive and oppositional behaviors, and to improve their long-term social functions.

Key words

Attention deficit hyperactivity disorder / Medication compliance / Methylphenidate / Child

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

DING Kai-Jing, LIU Yun-Fen, KANG Chuan-Yuan, LIU Rui-Xiang, LI Xue-Rong, WAN Shuai. Influential factors for methylphenidate treatment compliance in children with attention deficit hyperactivity disorder[J]. Chinese Journal of Contemporary Pediatrics. 2013, 15(5): 343-347 https://doi.org/10.7499/j.issn.1008-8830.2013.05.006

References

［1］Polanczyk G, de Lima MS, Horta BL, Biederman J, Rohde LA. The worldwide prevalence of ADHD: a systematic review and metaregression analysis［J］. Am J Psychiatry, 2007, 164(6): 942-948.

［2］杨莉, 王玉凤. 儿童注意缺陷多动障碍共病研究［J］. 中华医学杂志,2003, 83(13): 1190-1191.

［3］李岳玲,钱秋瑾,王玉凤. 儿童注意缺陷多动障碍成人期预后及其预测因素［J］. 北京大学学报（医学版）, 2007, 39(3): 337-339.

［4］Santosh PJ, Taylor E. Stimulant drugs［J］. Eur Child Adolesc Psychiatry, 2000, 9(1): 127-143.

［5］Barkley RA, Murphy KR. Attention-deficit hyperactivity disorder: a clinical work book［M］.3nd ed. New York: Guildford, 2005: 39-43.

［6］陶国泰, 郑毅, 宋维村. 儿童少年精神医学(第2版)［M］. 南京：江苏科学技术出版社，2008:247-258.

［7］Zhang S, Faries DE, Vowles M, Michelson D. ADHD Rating Scale IV: psychometric properties from a multinational study as a clinician-administered instrument［J］. Int J Methods Psychiatr Res, 2005, 14(4): 186-201.

［8］范娟, 杜亚松, 王立伟. Conners父母用症状问卷的中国城市常模和信度研究［J］. 上海精神医学, 2005,17(6):321-323.

［9］Barkley RA, McMurray MB, Edelbrock CS, Robbins K. Side effects of methylphenidate in children with attention deficit hyperactivity disorder: a systemic, placebo-controlled evaluation［J］. Pediatrics, 1990, 86(2): 184-192.

［10］Matthys W, Cuperus JM, Van Engeland H. Deficient social problem-solving in boys with ODD/CD, with ADHD, and with both disorders［J］. J Am Acad Child Adolesc Psychiatry, 1999, 38(3):311-321.

［11］Barkley RA, Fischer M, Smallish L. Young adult follow-up of hyperactive children: antisocial activities and drug use［J］. J Child Psychol Psych Allied Discipl, 2004, 45(2): 195-211.

［12］朱大倩, 高鸿云, 朱雍雍. 哌甲酯治疗门诊注意缺陷多动障碍患儿的依从性研究［J］. 中国儿童保健杂志, 2011,19(3): 267-269.

［13］Montoya A, Colom F, Ferrin M. Is psychoeducation for parents and teachers of children and adolescents with ADHD efficacious? A systematic literature review［J］. Eur Psych, 2011, 26(3): 166-175.

［14］陈言钊, 文飞球, 周克英, 杨春何, 张蔚, 李宁. 不同亚型注意力缺陷多动障碍患儿的临床特征分析［J］. 中国当代儿科杂志, 2010,12(9):704-708.

［15］DosReis S, Mychailyszyn MP, Evans-Lacko SE, Beltran A, Riley AW, Myers MA. The meaning of attention-deficit/hyperactivity disorder medication and parents′initiation and continuity of treatment for their child［J］. J Child Adolesc Psychopharmacol, 2009, 19(4): 377-383.

［16］McGuinness TM. Helping parents decide on ADHD treatment for their children［J］. J Psychosoc Nurs Ment Health Serv, 2008, 46(8): 23-27.

［17］刘敏珍, 陈燕惠, 林桂秀, 陈晶, 吕红艳. 影响注意缺陷多动障碍患儿药物依从性因素的分析［J］. 中国社区医师（医学专业）, 2011,13(14):20-21.

［18］Charach A, Gajaria A. Improving psychostimulant adherence in children with ADHD［J］. Expert Rev Neurother, 2008, 8(10): 1563-1571.