Therapeutic effect of clofarabine in children with relapsed or refractory acute lymphoblastic leukemia

SUO Pan; ZHANG Le-Ping; WU Jun; LU Ai-Dong; WANG Bin; ZUO Ying-Xi; CHENG Yi-Fei; LIU Gui-Lan

doi:10.7499/j.issn.1008-8830.2013.06.012

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Chinese Journal of Contemporary Pediatrics ›› 2013, Vol. 15 ›› Issue (6) : 444-447. DOI: 10.7499/j.issn.1008-8830.2013.06.012

CLINICAL RESEARCH

Therapeutic effect of clofarabine in children with relapsed or refractory acute lymphoblastic leukemia

SUO Pan, ZHANG Le-Ping, WU Jun, LU Ai-Dong, WANG Bin, ZUO Ying-Xi, CHENG Yi-Fei, LIU Gui-Lan

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Abstract

OBJECTIVE: To explore the efficacy and adverse effects of clofarabine for relapsed/refractory acute lymphoblastic leukemia in children. METHODS: Twentysix pediatric patients with relapsed/refractory acute lymphoblastic leukemia were treated with clofarabine. There were 22 males and 4 females, with a mean age of 9.5 years (ranging from 4 to 17 years). They received clofarabine 52 mg/m2 intravenously over 2 hours daily for 5 days. Thirteen patients received two cycles and one patient received three cycles. RESULTS: In the first cycle of clofarabine, complete remission was obtained in 11 children (42%) and partial remission was obtained in 7 children (27%). Eight children (31%) were considered unresponsive. In the second cycle, 11 (85%) of the 13 children obtained complete remission, 1 (8%) partial remission and 1 (8%) was unresponsive. One child received three cycles and obtained complete remission in each cycle. The common adverse events were myelosuppression, infection, liver dysfunction and gastrointestinal adverse reactions. There were no chemotherapy-related deaths.ConclusionsClofarabine is effective in the treatment of children with relapsed/refractory acute lymphoblastic leukemia and its adverse effects can be tolerated. Clofarabine could be a promising new treatment for relapsed/refractory acute lymphoblastic leukemia.

Key words

Clofarabine / Acute lymphoblastic leukemia / Relapsed/refractory / Child

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SUO Pan, ZHANG Le-Ping, WU Jun, LU Ai-Dong, WANG Bin, ZUO Ying-Xi, CHENG Yi-Fei, LIU Gui-Lan. Therapeutic effect of clofarabine in children with relapsed or refractory acute lymphoblastic leukemia[J]. Chinese Journal of Contemporary Pediatrics. 2013, 15(6): 444-447 https://doi.org/10.7499/j.issn.1008-8830.2013.06.012

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