Viral etiology in children with acute lower respiratory tract infections plus platelet disorders in Changsha, China：an analysis of 255 cases

LIU Hua; HE Xiang-Ling; ZHANG Bing; XIAO Ni-Guang; YOU Ya-Lan; DUAN Zhao-Jun

doi:10.7499/j.issn.1008-8830.2014.04.020

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Chinese Journal of Contemporary Pediatrics ›› 2014, Vol. 16 ›› Issue (4) : 406-409. DOI: 10.7499/j.issn.1008-8830.2014.04.020

CLINICAL RESEARCH

Viral etiology in children with acute lower respiratory tract infections plus platelet disorders in Changsha, China：an analysis of 255 cases

LIU Hua¹, HE Xiang-Ling¹, ZHANG Bing¹, XIAO Ni-Guang¹, YOU Ya-Lan¹, DUAN Zhao-Jun²

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Abstract

Objective To investigate the viral etiology in hospitalized children with acute lower respiratory tract infections (ALRTI) plus platelet disorders. Methods A total of 255 children with ALRTI plus platelet disorders and 442 children with ALRTI and normal platelets, all of whom were hospitalized between March 2010 and February 2011, were included in the study. Their nasopharyngeal aspirate samples were collected, and RT-PCR or PCR was performed to detect 14 viruses. Results Of 255 ALRTI patients with platelet disorders, thrombocytosis was found in 253 cases (99.2%) and thrombocytopenia in 2 cases (0.8%). Among ALRTI patients with platelet disorders, 173 (67.8%) were infected with at least one virus, with human rhinovirus as the most common one, followed by parainfluenza virus type 3 (PIV3) and respiratory syncytial virus (RSV). The detection rate of PIV3 in the abnormal platelet group was significantly higher than in the normal platelet group (P<0.05). In contrast, the detection rate of influenza virus B (IFVB) in the abonormal platelet group was significantly lower than in the normal platelet group (P<0.05). The age distribution showed significant difference between the abnormal and normal platelet groups (P<0.01). Platelet disorders were mainly found in children under one year of age (P<0.01). Conclusions Thrombocytosis is often found in children with ALRTI caused by viruses, especially PIV3, but infection with IFVB seldom causes platelet disorders. Hospitalized children with ALRTI under one year tend to develop platelet disorders.

Key words

Thrombocytosis / Thrombocytopenia / Acute lower respiratory tract infection / Virus / Child

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LIU Hua, HE Xiang-Ling, ZHANG Bing, XIAO Ni-Guang, YOU Ya-Lan, DUAN Zhao-Jun. Viral etiology in children with acute lower respiratory tract infections plus platelet disorders in Changsha, China：an analysis of 255 cases[J]. Chinese Journal of Contemporary Pediatrics. 2014, 16(4): 406-409 https://doi.org/10.7499/j.issn.1008-8830.2014.04.020

References

[1] 胡亚美, 江载芳. 诸福棠实用儿科学[M]. 第7版. 北京: 人民卫生出版社, 2002: 1785．
[2] 肖霓光, 张兵, 段招军, 等. 1165例急性下呼吸道感染住院儿童的病毒病原学分析[J].中国当代儿科杂志, 2012, 14(1): 28-32．
[3] Waghmare A, Campbell AP, Xie H, et al. Respiratory syncytial virus lower respiratory disease in hematopoietic cell transplant recipients: viral RNA detection in blood, antiviral treatment, and clinical outcomes[J]. Clin Infect Dis, 2013, 57(12): 1731-1741.
[4] Seto WH, Conly JM, Pessoa-Silva CL, et al. Infection prevention and control measures for acute respiratory infections in healthcare settings: an update[J]. East Mediterr Health J, 2013, 19(1): 39-47.
[5] Munywoki PK, Ohuma EO, Ngama M, et al. Severe lower respiratory tract infection in early infancy and pneumonia hospitalizations among children, Kenya[J]. Emerg Infect Dis, 2013, 19(2): 223.
[6] 张园海, 徐强, 吴蓉洲, 等. 病毒性下呼吸道感染患儿血小板的变化及临床意义[J].中国实用儿科杂志, 2008, 23(4): 298-300.
[7] 刘颖.儿童感染相关血小板增多症病例分析[J].当代医学, 2009, 15(18): 45.
[8] Mammas I, Koutsaftiki C, Tapaki-Papadopoulou G, et al. Respiratory syncytial virus (RSV) bronchiolitis and excessivethrombocytosis[J]. Acta Paediatr, 2010, 99(4): 489-490.
[9] Bilavsky E, Yarden-Bilavsky H, Shouval DS, et al. Respiratory syncytial virus-positive bronchiolitis in hospitalized infants is associated with thrombocytosis[J]. Isr Med Assoc J, 2010, 12(1): 39-41.
[10] Zhang RF, Jin Y, Xie ZP, et al. Human respiratory syncytial virus in children with acute respiratory tract infections in China[J]. J Clin Microbiol, 2010, 48(11): 4193-4199.
[11] Beka H, Kilic A, Unuvar E, et al. Frequency of common viruses in etiology of acute respiratory tract infections[J]. Indian J Pediatr, 2013, 80(2): 91-96.
[12] 赵艳丰, 雷忠英, 王琳, 等. 南京地区住院儿童副流感病毒感染监测[J]. 临床儿科杂志, 2013, 31(1): 52-54.
[13] 陈祺棠, 王缉干, 罗建明. 小儿特发性血小板减少性紫癜的发病机制及治疗进展[J]. 医学综述, 2012, 18(7): 1062-1065.
[14] Liu Y, Wu B, Paessler S, et al. The pathogenesis of severe fever with thrombocytopenia syndrome virus infection in Alpha/beta interferon knockout mice: insights into the pathologic mechanisms of a new viral hemorrhagic fever[J]. J Virol, 2014, 88(3): 1781-1786.
[15] Bilavsky E, Yarden-Bilavsky H, Shouval DS, et al. Respiratory syncytia virus-positive bronchiolitis in hospitalized infants is associated with thrombocysis[J]. Isr Med Assoc, 2010, 12(1): 39-41.
[16] Cecinati V, Brescia L, Esposito S, et al. Thrombocytosis and infections in childhood[J]. Pediatr Infect Dis, 2012, 31(1): 80-81.