Therapeutic effect of ketogenic diet for refractory epilepsy in children：a prospective observational study

ZHU Deng-Na; XIE Meng-Meng; WANG Jun-Hui; WANG Jun; MA De-You; SUN Li; LI Lin-Chen; WANG Ming-Mei

doi:10.7499/j.issn.1008-8830.2014.05.014

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Chinese Journal of Contemporary Pediatrics ›› 2014, Vol. 16 ›› Issue (5) : 513-517. DOI: 10.7499/j.issn.1008-8830.2014.05.014

CLINICAL RESEARCH

Therapeutic effect of ketogenic diet for refractory epilepsy in children：a prospective observational study

ZHU Deng-Na, XIE Meng-Meng, WANG Jun-Hui, WANG Jun, MA De-You, SUN Li, LI Lin-Chen, WANG Ming-Mei

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Abstract

Objective To study the clinical efficiency, electroencephalogram (EEG) changes and cognitive improvements of ketogenic diet (KD) in children with refractory epilepsy. Methods Twenty pediatric patients (7-61 months in age) with refractory epilepsy were recruited between August 2012 and August 2013. KD therapy was performed on all participants for at least 3 months based on a fasting initiation protocol with the lipid-to-nonlipid ratio being gradually increased to 4:1. Seizure frequency, type and degree were recorded before and during KD therapy. A 24 hours video-electroencephalogram (V-EEG) examination and Gesell Developmental Scale assessment were performed prior to KD therapy, and 3, 6, 9 months after KD therapy. Results Six patients became seizure free after KD therapy, with a complete control rate of 30%. Seizure frequency reduction occurred in 13 (65%) patients, EEG improvement in 8 (40%) patients, and improvement in Gesell Developmental Scales (gross motor and adaptability in particular) in 6 (30%) patients. The KD therapy-related side effects were mild. Conclusions KD therapy is safety and effective in reducing seizure frequency and improving EEG and cognitive function in children with refractory epilepsy.

Key words

Refractory epilepsy / Ketogenic diet / Cognitive function / Video-electroencephalogram / Child

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ZHU Deng-Na, XIE Meng-Meng, WANG Jun-Hui, WANG Jun, MA De-You, SUN Li, LI Lin-Chen, WANG Ming-Mei. Therapeutic effect of ketogenic diet for refractory epilepsy in children：a prospective observational study[J]. Chinese Journal of Contemporary Pediatrics. 2014, 16(5): 513-517 https://doi.org/10.7499/j.issn.1008-8830.2014.05.014

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