Management of anti-N-methyl-D-aspartate receptor encephalitis in children

ZHONG Jian-Min

Chinese Journal of Contemporary Pediatrics ›› 2014, Vol. 16 ›› Issue (6) : 584-588.

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Chinese Journal of Contemporary Pediatrics ›› 2014, Vol. 16 ›› Issue (6) : 584-588. DOI: 10.7499/j.issn.1008-8830.2014.06.005
TOPIC OF ANTI-NMDAR ENCEPHALITIS

Management of anti-N-methyl-D-aspartate receptor encephalitis in children

  • ZHONG Jian-Min
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Abstract

Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a new category of severe, potentially treatable autoimmune encephalitis and can appear in patients of all ages, but more frequently in children. It is a highly characteristic syndrome evolving in five stages: the prodromal phase (viral infection-like symptoms), psychotic phase, unresponsive phase, hyperkinetic phase, and gradual recovery phase. The treatment for this disorder includes firstline immunotherapy (steroids, intravenous immunoglobulin, plasmapheresis), second-line immunotherapy (rituximab, cyclophosphamide), and tumor removal. Hereby the progresses, selections and shortcomings of the treatment protocols for this disease are introduced.

Key words

Anti-N-methyl-D-aspartate receptor encephalitis / Immunotharapy / Tumor resection / Child

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ZHONG Jian-Min. Management of anti-N-methyl-D-aspartate receptor encephalitis in children[J]. Chinese Journal of Contemporary Pediatrics. 2014, 16(6): 584-588 https://doi.org/10.7499/j.issn.1008-8830.2014.06.005

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