Risk factors for multidrug-resistant Klebsiella pneumoniae sepsis in children

CHENG Chao; LIN Ye-Xin; LI Jiu-Jun; ZHANG Zhi-Jie

doi:10.7499/j.issn.1008-8830.2015.09.009

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Chinese Journal of Contemporary Pediatrics ›› 2015, Vol. 17 ›› Issue (9) : 932-936. DOI: 10.7499/j.issn.1008-8830.2015.09.009

CLINICAL RESEARCH

Risk factors for multidrug-resistant Klebsiella pneumoniae sepsis in children

CHENG Chao¹, LIN Ye-Xin¹, LI Jiu-Jun¹, ZHANG Zhi-Jie²

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Abstract

Objective To explore the risk factors for sepsis caused by multidrug-resistant Klebsiella pneumonia (MDR-KP) and to provide a reference for the prevention of MDR-KP sepsis and rational use of antibiotics.Methods A retrospective case-control study of 41 children with MDR-KP sepsis (case group) and 53 pediatric patients without MDR-KP sepsis (control group) between March 2010 and Febrary 2014 was conducted. Multiple logistic regression analysis was performed to estimate the independent risk factors for MDR-KP sepsis.Results Compared with the control group, the case group had a longer length of stay in the PICU before infection (P<0.05), more prolonged duraion of mechanical ventilation before infection (P<0.05), a larger total number of days of mechanical ventilation (P<0.05), more days of antibiotic use before infection (P<0.05), more types of antibiotics used before infection (P<0.05), and a higher mortality (P<0.05). The logistic regression analysis showed that more types of antibiotics used before infection and use of third-generation cephalosporin and carbapenems were independent risk factors for MDR-KP sepsis (P<0.05).Conclusions Rational use of antibiotics is an effective measure to prevent MDR-KP sepsis.

Key words

Multidrug resistant Klebsiella Pneumoniae / Sepsis / Risk factor / Child

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CHENG Chao, LIN Ye-Xin, LI Jiu-Jun, ZHANG Zhi-Jie. Risk factors for multidrug-resistant Klebsiella pneumoniae sepsis in children[J]. Chinese Journal of Contemporary Pediatrics. 2015, 17(9): 932-936 https://doi.org/10.7499/j.issn.1008-8830.2015.09.009

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