Abstract Objective To investigate the risk factors, clinical features, and magnetic resonance imaging (MRI) changes of encephalopathy in high-risk late preterm infants. Methods Head MRI scan was performed for late preterm infants with high-risk factors for brain injury who were hospitalized between January 2009 and December 2014. The risk factors, clinical features, and head MRI features of encephalopathy in late preterm infants were analyzed. Results A total of 1 007 late preterm infants underwent MRI scan, among whom 313 (31.1%) had imaging features in accordance with the features of encephalopathy of prematurity. Of all infants, 76.7% had white matter damage. There was no association between the development of encephalopathy and gestational age in late preterm infants, but the detection rate of encephalopathy gradually increased with the increasing birth weight (P P Conclusions Encephalopathy of prematurity is commonly seen in high-risk late preterm infants, especially white matter damage. A history of resuscitation is an independent risk factor for encephalopathy in late preterm infants.
ZHU Yan,ZHANG Ke,HU Lan et al. Clinical features and magnetic resonance imaging evaluation of encephalopathy in high-risk late preterm infants[J]. CJCP, 2017, 19(5): 567-571.
ZHU Yan,ZHANG Ke,HU Lan et al. Clinical features and magnetic resonance imaging evaluation of encephalopathy in high-risk late preterm infants[J]. CJCP, 2017, 19(5): 567-571.
Martin JA, Hamilton BE, Osterman MJ, et al. Births:Final Data for 2015[J]. Natl Vital Stat Rep, 2017, 66(1):1.
[2]
Harijan P, Boyle EM. Health outcomes in infancy and childhood of moderate and late preterm infants[J]. Semin Fetal Neonatal Med, 2012, 17(3):159-162.
[3]
Mercuri E, Ricci D, Romeo DM. Neurological and visual assessments in very and late low-risk preterm infants[J]. Early Hum Dev, 2012, 88(Suppl 1):S31-S33.
[4]
Teune MJ, Bakhuizen S, Gyamfi Bannerman C, et al. A systematic review of severe morbidity in infants born late preterm[J]. Am J Obstet Gynecol, 2011, 205(4):374.
[5]
McGowan JE, Alderdice FA, Holmes VA, et al. Early childhood development of late-preterm infants:a systematic review[J]. Pediatrics, 2011, 127(6):1111-1124.
Shapiro-Mendoza CK, Tomashek KM, Kotelchuck M, et al. Risk factors for neonatal morbidity and mortality among "healthy," late preterm newborns[J]. Semin Perinatol, 2006, 30(2):54-60.
[8]
Talge NM, Holzman C, Wang J, et al. Late-preterm birth and its association with cognitive and socioemotional outcomes at 6 years of age[J]. Pediatrics, 2010, 126(6):1124-1131.
[9]
Moster D, Lie RT, Markestad T. Long-term medical and social consequences of preterm birth[J]. N Engl J Med, 2008, 359(3):262-273.
Woodward LJ, Anderson PJ, Austin NC, et al. Neonatal MRI to predict neurodevelopmental outcomes in preterm infants[J]. N Engl J Med, 2006, 355(7):685-694.
[12]
Shapiro-Mendoza CK, Lackritz EM. Epidemiology of late and moderate preterm birth[J]. Semin Fetal Neonatal Med, 2012. 17(3):120-125.
[13]
Martin JA, Hamilton BE, Sutton PD, et al. Births:final data for 2008[J]. Natl Vital Stat Rep, 2010. 59(1):1, 3-71.
Petrini JR, Dias T, McCormick MC, et al. Increased risk of adverse neurological development for late preterm infants[J]. J Pediatr, 2009, 154(2):169-176.
Woodward LJ, Clark CA, Bora S, et al. Neonatal white matter abnormalities an important predictor of neurocognitive outcome for very preterm children[J]. PLoS One, 2012, 7(12):e51879.
[18]
Inder TE, Wells SJ, Mogridge NB, et al. Defining the nature of the cerebral abnormalities in the premature infant:a qualitative magnetic resonance imaging study[J]. J Pediatr, 2003, 143(2):171-179.
[19]
Roelants-van RAM, Groenendaal F, Beek FJ, et al. Parenchymal brain injury in the preterm infant:comparison of cranial ultrasound, MRI and neurodevelopmental outcome[J]. Neuropediatrics, 2001, 32(2):80-89.
[20]
Sie LT, Hart AA, van Hof J, et al. Predictive value of neonatal MRI with respect to late MRI findings and clinical outcome. A study in infants with periventricular densities on neonatal ultrasound[J]. Neuropediatrics, 2005, 36(2):78-89.
