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Predictive value of red blood cell distribution width for acute kidney injury in children with sepsis
ZHANG Lin, GUO Kuan-Peng, MO Yi, YI Su-Wu, HUANG Cai-Zhi, LONG Cai-Xia, MO Li-Ya
Chinese Journal of Contemporary Pediatrics ›› 2018, Vol. 20 ›› Issue (7) : 559-562.
PDF(1108 KB)
PDF(1108 KB)
Predictive value of red blood cell distribution width for acute kidney injury in children with sepsis
Objective To study the clinical value of red blood cell distribution width (RDW) in the early prediction of acute kidney injury (AKI) in children with sepsis.Methods A total of 126 children with sepsis were divided into an AKI group (n=66) and a non-AKI group (n=60) according to the presence or absence of AKI. These patients were also classifed into high-RDW and low-RDW groups according to the mean RDW. The groups were compared in terms of age, male-to-female ratio, body mass index (BMI), Acute Physiology and Chronic Health Evaluation Ⅱ (APACHE Ⅱ) score, Sequential Organ Failure Assessment (SOFA) score, serum blood urea nitrogen (BUN), creatinine (Cr), uric acid (UA), serum C-reactive protein (CRP), and routine blood test results. Independent factors associated with RDW were analyzed by multiple linear regression.Results Age, male-to-female ratio, BMI, CRP, SOFA score, and APACHE Ⅱ score did not differ signifcantly between the AKI and non-AKI groups (P > 0.05), but the AKI group had signifcantly higher BUN, Cr, UA, and RDW levels than the non-AKI group (P < 0.05). Age, male-to-female ratio, and BMI did not differ signifcantly between the high-RDW and low-RDW groups (P > 0.05), but the high-RDW group had signifcantly higher BUN, Cr, UA, CRP, SOFA score, APACHE Ⅱ score, Hb, and mean corpuscular volume (MCV) than the lowRDW group (P < 0.05). The multiple linear regression analysis showed that age, sex, APACHE Ⅱ score, Cr, Hb, and MCV were independent factors associated with RDW.Conclusions RDW has a certain clinical value in the early prediction of AKI in children with sepsis.
Sepsis / Red blood cell distribution width / Acute kidney injury / Child
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