Association between the inter-aural latency difference of brainstem auditory evoked potential wave V and neonatal hyperbilirubinemia

ZHENG Zong, LIU Hong-Yan, YANG Shan-Pu, DU Li-Zhong

Chinese Journal of Contemporary Pediatrics ›› 2021, Vol. 23 ›› Issue (5) : 499-504.

PDF(1438 KB)
PDF(1438 KB)
Chinese Journal of Contemporary Pediatrics ›› 2021, Vol. 23 ›› Issue (5) : 499-504. DOI: 10.7499/j.issn.1008-8830.2102049
CLINICAL RESEARCH

Association between the inter-aural latency difference of brainstem auditory evoked potential wave V and neonatal hyperbilirubinemia

  • ZHENG Zong1, LIU Hong-Yan1, YANG Shan-Pu1, DU Li-Zhong2
Author information +
History +

Abstract

Objective To study brainstem auditory evoked potential (BAEP) in neonates with hyperbilirubinemia using short auditory stimuli (60 dBnHL), and to investigate the differences in the inter-aural latency difference (ILD) of wave V between neonates with different total serum bilirubin (TSB) levels. Methods A prospective study was conducted in neonates with hyperbilirubinemia who were admitted to the Department of Neonatology, Yuhuan People's Hospital of Zhejiang Province, from May 2019 to October 2020. The neonates were divided into a severe group (n=50) and a mild group (n=50) according to their TSB levels. The mild group was divided into two subgroups: 7-10 days (n=20) and 11-14 days (n=20) according to their age. ILD was compared between the neonates with different TSB levels, and its diagnostic value was analyzed. Results Compared with the mild group, the severe group had significantly higher proportions of neonates with abnormal hearing threshold and abnormal ILD (P < 0.05) and a significantly larger ILD of wave V (P < 0.05). The latency of wave V (left ear) in the 7-10 days subgroup was significantly longer than that in the 11-14 days subgroup (P < 0.05), but there was no significant difference in the ILD of wave V between the two groups (P > 0.05). The receiver operating characteristic (ROC) analysis showed that ILD had predictive value for hearing impairment caused by neonatal hyperbilirubinemia (P < 0.05), with an area under the ROC curve of 0.727 as well as a sensitivity of 52.4% and a specificity of 90.9% at the optimal cut-off value of 0.365 ms. Conclusions Serum bilirubin in neonates affects the ILD of BAEP wave V, especially in those with severe hyperbilirubinemia. ILD at the optimal cut-off value of ≥0.4 ms shows potential value in the diagnosis of hearing impairment caused by neonatal hyperbilirubinemia.

Key words

Neonatal hyperbilirubinemia / Brainstem auditory evoked potential / Latency of wave V / Inter-aural latency difference / Neonate

Cite this article

Download Citations
ZHENG Zong, LIU Hong-Yan, YANG Shan-Pu, DU Li-Zhong. Association between the inter-aural latency difference of brainstem auditory evoked potential wave V and neonatal hyperbilirubinemia[J]. Chinese Journal of Contemporary Pediatrics. 2021, 23(5): 499-504 https://doi.org/10.7499/j.issn.1008-8830.2102049

References

[1] Kim MH, Yoon JJ, Sher J, et al. Lack of predictive indices in kernicterus:a comparison of clinical and pathologic factors in infants with or without kernicterus[J]. Pediatrics, 1980, 66(6):852-858.
[2] Turkel SB, Guttenberg ME, Moynes DR, et al. Lack of identifiable risk factors for kernicterus[J]. Pediatrics, 1980, 66(4):502-506.
[3] Nam GS, Kwak SH, Bae SH, et al. Hyperbilirubinemia and follow-up auditory brainstem responses in preterm infants[J]. Clin Exp Otorhinolaryngol, 2019, 12(2):163-168.
[4] 韩东一, 翟所强, 韩维举. 临床听力学[M]. 2版. 北京:中国协和医科大学出版社, 2008:267-284.
[5] Amin SB, Ahlfors C, Orlando MS, et al. Bilirubin and serial auditory brainstem responses in premature infants[J]. Pediatrics, 2001, 107(4):664-670.
[6] Sharma M, Bist SS, Kumar S. Age-related maturation of wave V latency of auditory brainstem response in children[J]. J Audiol Otol, 2016, 20(2):97-101.
[7] Pinto ESM, Martinelli MC. Brainstem auditory evoked potentials with speech stimulus in neonates[J]. Braz J Otorhinolaryngol, 2020, 86(2):191-200.
[8] 胡鸿, 史波宁. V波潜伏期差值与I-V波间期差值的关系研究[J]. 中华耳科学杂志, 2016, 14(3):370-373.
[9] Singh V, Agrawal U, Chaudhary AK, et al. Study of variation and latency of wave V of brain stem evoked response audiometry in north central India[J]. Indian J Otolaryngol Head Neck Surg, 2019, 71(Suppl 2):1408-1411.
[10] Lewis JD, Kopun J, Neely ST, et al. Tone-burst auditory brainstem response wave V latencies in normal-hearing and hearing-impaired ears[J]. J Acoust Soc Am, 2015, 138(5):3210-3219.
[11] Joo JW, Jeong YJ, Han MS, et al. Analysis of auditory brainstem response change, according to tinnitus duration, in patients with tinnitus with normal hearing[J]. J Int Adv Otol, 2020, 16(2):190-196.
[12] Aihara N, Murakami S, Takemura K, et al. Interaural difference of wave V predicting postoperative hearing in Gardner-Robertson class II acoustic neuroma patients[J]. J Neurol Surg B Skull Base, 2013, 74(5):274-278.
[13] Shih C, Tseng FY, Yeh TH, et al. Ipsilateral and contralateral acoustic brainstem response abnormalities in patients with vestibular schwannoma[J]. Otolaryngol Head Neck Surg, 2009, 141(6):695-700.
[14] 李蕴, 陈向平, 吴皓, 等. 听觉脑干诱发电位波形变化在听神经瘤诊断中的意义[J]. 中国耳鼻咽喉颅底外科杂志, 2006, 12(3):207-209.
[15] 邵肖梅, 叶鸿瑁, 丘小汕. 实用新生儿学[M]. 4版. 北京:人民卫生出版社, 2011.
[16] Boo NY, Rohani AJ, Asma A. Detection of sensorineural hearing loss using automated auditory brainstem-evoked response and transient-evoked otoacoustic emission in term neonates with severe hyperbilirubinaemia[J]. Singapore Med J, 2008, 49(3):209-214.
[17] 杜立中. 新生儿高胆红素血症[M]. 北京:人民卫生出版社, 2015.
[18] Du LZ, Ma XL. International perspectives hyperbilirubinemia and kernicterus in neonates in China[J]. Neoreviews, 2012, 13(3):e141-e144.
[19] Matsuura Y, Oguri M, Saito Y, et al. Decreased wave V amplitude in auditory brainstem responses of children with cerebellar lesions[J]. Yonago Acta Med, 2018, 61(4):220-227.
[20] 中华医学会儿科学分会新生儿学组, 《中华儿科杂志》编辑委员会. 新生儿高胆红素血症诊断和治疗专家共识[J]. 中华儿科杂志, 2014, 52(10):745-748.

PDF(1438 KB)

Accesses

Citation

Detail

Sections
Recommended

/