Objective To investigate the epidemic situation of hand-foot-mouth disease (HFMD) in Hunan Province, China, from 2008 to 2019, as well as its spatial autocorrelation characteristics and spatial-temporal clustering, and to provide a reference for the prevention and control of HFMD in Hunan Province. Methods Spatial autocorrelation and spatial-temporal clustering analyses were used to analyze the monitoring data of HFMD in Hunan Province from 2008 to 2019. Results The epidemic situation of HFMD in Hunan Province from 2008 to 2019 showed obvious seasonal distribution, with a low incidence rate in January to March and a high incidence rate in April to July. As for population distribution, children aged 0-5 years had the highest number of HFMD cases and accounted for 95.89% (1 460 391/1 522 910) of all cases, with a mean annual incidence rate of 2 197.784/100 000, and scattered children had the highest number of cases and accounted for 82.59% (1 257 739/1 522 910) of all cases. The global spatial autocorrelation analysis showed that the onset of HFMD in Hunan Province showed a significant clustering distribution, and the local spatial autocorrelation analysis showed that the high clustering areas of HFMD were mainly the districts and counties of Changsha, Zhuzhou, and Yueyang cities. Time-space scanning showed that clustering time was mainly April to July; the cases were clustered in the northeast of Hunan Province from 2008 to 2010 and in the central part of Hunan Province from 2011 to 2019. Conclusions The high incidence rate of HFMD is observed in April to July in Hunan Province. Children under 5 years of age are at a high risk of this disease. Spatial-temporal clustering is observed for the epidemic of HFMD, mainly clustered in the northeastern and central areas of Hunan Province. It is suggested that the results may be used as guidance to determine the key areas for HFMD prevention and control in Hunan Province and optimize the allocation of health resources.
Key words
Hand-foot-mouth disease /
Epidemiological characteristics /
Spatial autocorrelation /
Time-space scanning /
Child
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References
1 国家卫生健康委员会. 手足口病诊疗指南(2018年版)[J]. 中国病毒病杂志, 2018, 8(5): 347-352. DOI: 10.16505/j.2095-0136.2018.0063.
2 董晶. 长沙市手足口病疫情分布特征及预测模型的建立与评估[D]. 长沙: 中南大学, 2014.
3 吴欣锐, 黎祺, 罗垲炜, 等. 湖南省2009至2015年手足口病疫情及时空聚集性变化趋势[J]. 中南大学学报(医学版), 2016, 41(8): 865-871. PMID: 27600017. DOI: 10.11817/j.issn.1672-7347.2016.08.016.
4 马桂花. 湖南省手足口病时空分布及风险因子研究[D]. 长沙: 湖南师范大学, 2016.
5 郑仕喜. 长沙市手足口病时空聚集性及其发病趋势预测研究[D]. 长沙: 湖南师范大学, 2016.
6 郑仕喜, 罗垲炜, 肖洪, 等. 2011－2014年长沙市手足口病流行病学特征及其时空聚集性分析[J]. 实用预防医学, 2016, 23(8): 1014-1018. DOI: 10.3969/j.issn.1006-3110.2016.08.038.
7 李鑫尧. 长株潭地区手足口病流行性特征及影响因子研究[D]. 长沙: 湖南师范大学, 2018.
8 湖南省统计局. 统计年鉴[EB/OL]. (2020-01-13)[2020-11-20]. http://tjj.hunan.gov.cn/hntj/tjsj/tjnj/index.html.
9 Waldh?r T. The spatial autocorrelation coefficient Moran's I under heteroscedasticity[J]. Stat Med, 1996, 15(7-9): 887-892. PMID: 8861157. DOI: 10.1002/(sici)1097-0258(19960415)15:7/9<887::aid-sim257>3.0.co;2-e.
10 李明. 不良妊娠结局发生空间分布及影响因素分析研究[D]. 北京: 中国疾病预防控制中心, 2020.
11 Liu H, Song GX, He N, et al. Spatial-temporal variation and risk factor analysis of hand, foot, and mouth disease in children under 5 years old in Guangxi, China[J]. BMC Public Health, 2019, 19(1): 1491. PMID: 31703735. PMCID: PMC6842152. DOI: 10.1186/s12889-019-7619-y.
12 Kulldorff M, Huang L, Pickle L, et al. An elliptic spatial scan statistic[J]. Stat Med, 2006, 25(22): 3929-3943. PMID: 16435334. DOI: 10.1002/sim.2490.
13 唐咸艳, 李峤, 仇小强, 等. 扫描统计量中最大空间扫描窗口的尺度选择[J]. 中华疾病控制杂志, 2015, 19(3): 316-317. DOI: 10.16462/j.cnki.zhjbkz.2015.03.028.
14 刘天, 姚梦雷, 陈红缨, 等. 时空扫描统计量在手足口病聚集性研究中的参数筛选[J]. 公共卫生与预防医学, 2020, 31(5): 49-52. DOI: 10.3969/j.issn.1006-2483.2020.05.013.
15 张静. 2008-2017年中国手足口病流行趋势和病原变化动态数列分析[J]. 中华流行病学杂志, 2019, 40(2): 147-154. PMID: 30744263. DOI: 10.3760/cma.j.issn.0254-6450.2019.02.005.
16 崔金朝, 聂陶然, 任敏睿, 等. 2008－2018年中国5岁及以下儿童手足口病死亡病例流行病学特征[J]. 中华流行病学杂志, 2020, 41(7): 1041-1046. PMID: 32741167. DOI: 10.3760/cma.j.cn112338-20200114-00031.
17 Bo ZY, Ma Y, Chang ZR, et al. The spatial heterogeneity of the associations between relative humidity and pediatric hand, foot and mouth disease: evidence from a nation-wide multicity study from mainland China[J]. Sci Total Environ, 2020, 707: 136103. PMID: 31874401. DOI: 10.1016/j.scitotenv.2019.136103.
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