孤独症谱系障碍儿童丘脑和小脑磁共振波谱特征和临床关系的前瞻性研究

doi:10.7499/j.issn.1008-8830.2108137

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Abstract Objective To study the changes in biochemical metabolites in the thalamus and the cerebellum and their association with clinical features in children with autism spectrum disorder (ASD). Methods In this prospective study, magnetic resonance spectroscopy (MRS) with point-resolved spatial selection was used to analyze the thalamus and the cerebellum at both sides in 50 children with ASD aged 2-6 years. Creatine (Cr) was as the internal standard to measure the relative values of N-acetylaspartate (NAA)/Cr, choline (Cho)/Cr, myoinositol (MI)/Cr, and glutamine and glutamate complex (Glx)/Cr, and the differences in metabolites and their association with clinical symptoms were compared. Results In the children with ASD, NAA/Cr in the left thalamus was positively correlated with the scores of hearing-language and hand-eye coordination in the Griffiths Development Scales-Chinese (P<0.05). Cho/Cr in the right cerebellum was positively correlated with the scores of personal-social competence, hearing-language, and hand-eye coordination (P<0.05). NAA/Cr and Glx/Cr in the left thalamus were positively correlated with those in the left cerebellum (P<0.05). There was no significant difference in metabolites between the left and right sides of the thalamus and the cerebellum in the children with ASD (P>0.05). Conclusions There are metabolic disorders in the cerebellum and the thalamus in children with ASD, and there is a correlation between the changes of metabolites in the left cerebellum and the left thalamus. Some metabolic indexes are related to the clinical symptoms of ASD. MRS may reveal the pathological basis of ASD and provide a basis for diagnosis and prognosis assessment of ASD as a noninvasive and quantitative detection method.

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	KANG Qian-Qian
	LI Xu
	TONG Guang-Lei
	FAN Ya-Lan
	SHI Lei

Key words： Autism spectrum disorder Magnetic resonance spectroscopy Thalamus Cerebellum Child

Received: 25 August 2021

Cite this article:

KANG Qian-Qian,LI Xu,TONG Guang-Lei et al. Magnetic resonance spectroscopy features of the thalamus and the cerebellum and their association with clinical features in children with autism spectrum disorder: a prospective study[J]. CJCP, 2021, 23(12): 1250-1255.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2108137 OR http://www.zgddek.com/EN/Y2021/V23/I12/1250

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