Objective To study the effect of hypertensive disorders of pregnancy on peripheral venous blood cell count in preterm infants with a gestational age of 28-34 weeks. Methods A total of 227 preterm infants with a gestational age of 28-34 weeks who were admitted to the Department of Pediatrics, the First Hospital Affiliated to Kunming Medical University, from January to December 2020, and whose mothers had hypertensive disorders of pregnancy were enrolled as the study group. A total of 227 preterm infants with a gestational age of 28-34 weeks who were admitted during the same period and whose mothers did not have hypertensive disorders of pregnancy were enrolled as the control group. According to maternal blood pressure during pregnancy, the study group was divided into three subgroups: gestational hypertension (n=75), mild preeclampsia (n=81), and severe preeclampsia (n=71). According to the birth weight of the preterm infants, the study group was divided into two subgroups: small for gestational age (SGA) (n=113) and appropriate for gestational age (AGA) (n=114). Peripheral blood cell count on day 1 after birth was compared between the study and control groups, as well as between the subgroups of the study group. Results Compared with the control group, the study group had significantly lower white blood cell count, absolute neutrophil count, and blood platelet count (P<0.05) and significantly higher incidence rates of leucopenia and neutropenia (P<0.05). The subgroup analysis showed that the mild preeclampsia and severe preeclampsia subgroups had significantly lower white blood cell count, absolute neutrophil count, and blood platelet count than the gestational hypertension subgroup (P<0.05), and that the SGA subgroup had significantly lower white blood cell count, absolute neutrophil count, and blood platelet count than the AGA subgroup (P<0.05). Conclusions Hypertensive disorders of pregnancy can affect the peripheral venous blood cell count of preterm infants, which is more significant in infants with maternal preeclampsia and SGA infants.
Key words
Hypertensive disorders of pregnancy /
Preeclampsia /
Blood cell count /
Preterm infant
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
1 Cakir SC, Dorum BA, Koksal N, et al. The effects of maternal preeclampsia on inflammatory cytokines and clinical outcomes in premature infants[J]. Pak J Med Sci, 2020, 36(2): 26-31. PMID: 32063926. PMCID: PMC6994880. DOI: 10.12669/pjms.36.2.1316.
2 Hao H, Gu X, Cai Y, et al. The influence of pregnancy-induced hypertension syndrome on the metabolism of newborns[J]. Transl Pediatr, 2021, 10(2): 296-305. PMID: 33708515. PMCID: PMC7944188. DOI: 10.21037/tp-20-211.
3 Getaneh T, Negesse A, Dessie G, et al. The impact of pregnancy induced hypertension on low birth weight in Ethiopia: systematic review and meta-analysis[J].Ital J Pediatr, 2020, 46(1): 174.PMID: 33243285. PMCID: PMC7690116. DOI: 10.1186/s13052-020-00926-0.
4 Chen SN, Cheng CC, Tsui KH, et al. Hypertensive disorders of pregnancy and future heart failure risk: a nationwide population-based retrospective cohort study[J]. Pregnancy Hypertens, 2018, 13: 110-115. PMID: 30177036. DOI: 10.1016/j.preghy.2018.05.010.
5 李婷, 朱丽敏, 张艳平, 等. 重度子痫前期极早产小于胎龄儿临床特点分析[J]. 中国当代儿科杂志, 2021, 23(3): 254-258. PMID: 33691918. PMCID: PMC7969190. DOI: 10.7499/j.issn.1008-8830.2011006.
6 Christensen RD, Yoder BA, Baer VL, et al. Early-onset neutropenia in small-for-gestational-age infants[J]. Pediatrics, 2015, 136(5): e1259-e1267. PMID: 26459642. DOI: 10.1542/peds.2015-1638.
7 乐杰, 谢幸, 林仲秋, 等. 妇产科学[M]. 7版. 北京: 人民卫生出版社, 2008: 94.
8 张家骧, 魏克伦, 薛辛东. 新生儿急救学[M]. 2版. 北京: 人民卫生出版社, 2006: 729-731.
9 Marins LR, Anizelli LB, Romanowski MD, et al. How does preeclampsia affect neonates? Highlights in the disease's immunity[J]. J Matern Fetal Neonatal Med, 2019, 32(7): 1205-1212. PMID: 29113524. DOI: 10.1080/14767058.2017.1401996.
10 Aneman I, Pienaar D, Suvakov S, et al. Mechanisms of key innate immune cells in early- and late-onset preeclampsia[J]. Front Immunol, 2020, 11: 1864. PMID: 33013837. PMCID: PMC7462000. DOI: 10.3389/fimmu.2020.01864.
11 Gregory EJ, Liu J, Miller-Handley H, et al. Epidemiology of pregnancy complications through the lens of immunological memory[J]. Front Immunol, 2021, 12: 693189. PMID: 34248991. PMCID: PMC8267465. DOI: 10.3389/fimmu.2021.693189.
12 Lu CQ, Lin J, Yuan L, et al. Pregnancy induced hypertension and outcomes in early and moderate preterm infants[J]. Pregnancy Hypertens, 2018, 14: 68-71. PMID: 30527121. DOI: 10.1016/j.preghy.2018.06.008.
13 Backes CH, Markham K, Moorehead P, et al. Maternal preeclampsia and neonatal outcomes[J]. J Pregnancy, 2011, 2011: 214365. PMID: 21547086. PMCID: PMC3087144. DOI: 10.1155/2011/214365.
14 Wirbelauer J, Thomas W, Rieger L, et al. Intrauterine growth retardation in preterm infants ≤32 weeks of gestation is associated with low white blood cell counts[J]. Am J Perinatol, 2010, 27(10): 819-824. PMID: 20480452. DOI: 10.1055/s-0030-1254547.
15 Procianoy RS, Silveira RC, Mussi-Pinhata MM, et al. Sepsis and neutropenia in very low birth weight infants delivered of mothers with preeclampsia[J]. J Pediatr, 2010, 157(3): 434-438, 438.e1. PMID: 20400101. DOI: 10.1016/j.jpeds.2010.02.066.
16 Letouzey M, Foix-L'Hélias L, Torchin H, et al. Cause of preterm birth and late-onset sepsis in very preterm infants: the EPIPAGE-2 cohort study[J]. Pediatr Res, 2021, 90(3): 584-592. PMID: 33627822. PMCID: PMC7903216. DOI: 10.1038/s41390-021-01411-y.
17 Oei J, Lui K, Wang H, et al. Decreased neutrophil apoptosis in tracheal fluids of preterm infants at risk of chronic lung disease[J]. Arch Dis Child Fetal Neonatal Ed, 2003, 88(3): F245-F249. PMID: 12719400. PMCID: PMC1721547. DOI: 10.1136/fn.88.3.f245.
18 Kalagiri RR, Choudhury S, Carder T, et al. Neonatal thrombocytopenia as a consequence of maternal preeclampsia[J]. AJP Rep, 2016, 6(1): e42-e47. PMID: 26929869. PMCID: PMC4737627. DOI: 10.1055/s-0035-1565923.
19 Bizerea TO, Stroescu R, Rogobete AF, et al. Pregnancy induced hypertension versus small weight for gestational age: cause of neonatal hematological disorders[J]. Clin Lab, 2018, 64(7): 1241-1248. PMID: 30146849. DOI: 10.7754/Clin.Lab.2018.180302.
20 朱咏臻, 唐树珍. 高海拔与低海拔地区人群血常规参数的差异分析[J]. 国际检验医学杂志, 2019, 40(12): 1458-1462. DOI: 10.3969/j.issn.1673-4130.2019.12.012.
PDF(504 KB)
