Objective To study the clinical application effect of "kindergarten effect" in radiotherapy for children with tumor based on the psychology of preschool children aged 3-5 years. Methods A total of 30 children, aged 3-5 years, who were admitted to the Department of Radiotherapy, Tianjin Medical University Cancer Institute and Hospital, from January 2020 to August 2021 were enrolled in this prospective study. The children were randomly divided into a control group and a test group, with 15 children in each group. The children in the test group were treated in "kindergarten mode", i.e., all children were treated together at a specified time and left together after all children completed treatment. Those in the control group were treated alternately with adult patients according to the treatment time based on the type of radiotherapy fixation device. The treatment compliance was evaluated for both groups, and the two groups were compared in terms of the setup errors in the superior-inferior (SI), left-right (LR), and anterior-posterior (AP) directions. Results Compared with the control group, the test group showed a significantly shorter time for finishing the treatment (P<0.05) and a significantly lower proportion of children with treatment interruption (P<0.05). Compared with the control group, the test group showed smaller mean errors in the SI, LR and AP directions after image-guided radiotherapy, with significant differences in the mean errors in the SI and LR directions (P<0.05). Conclusions With the application of the "kindergarten effect", most children can actively cooperate in radiotherapy, and it can also improve the accuracy and repeatability of positioning and help to achieve the desired treatment outcome.
Key words
Tumor /
Kindergarten effect /
Radiotherapy /
Child
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References
1 Jin Y, Lyu Q. Basic research in childhood cancer: progress and future directions in China[J]. Cancer Lett, 2020, 495: 156-164. PMID: 32841714. DOI: 10.1016/j.canlet.2020.08.014.
2 Milgrom SA, van Luijk P, Pino R, et al. Salivary and dental complications in childhood cancer survivors treated with radiation therapy to the head and neck: a Pediatric Normal Tissue Effects in the Clinic (PENTEC) comprehensive review[J]. Int J Radiat Oncol Biol Phys, 2021. PMID: 34074567. DOI: 10.1016/j.ijrobp.2021.04.023. Online ahead of print.
3 Inskip PD, Veiga LHS, Brenner AV, et al. Hyperthyroidism after radiation therapy for childhood cancer: a report from the childhood cancer survivor study[J]. Int J Radiat Oncol Biol Phys, 2019, 104(2): 415-424. PMID: 30769174. PMCID: PMC6818231. DOI: 10.1016/j.ijrobp.2019.02.009.
4 陈哲, 林茂, 曾力楠, 等. 水合氯醛口服溶液用于儿童镇静催眠安全性的系统评价[J]. 中国药房, 2020, 31(9): 1124-1131. DOI: 10.6039/j.issn.1001-0408.2020.09.19.
5 Sapkota Y, Cheung YT, Moon W, et al. Whole-genome sequencing of childhood cancer survivors treated with cranial radiation therapy identifies 5p15.33 locus for stroke: a report from the St. Jude lifetime cohort study[J]. Clin Cancer Res, 2019, 25(22): 6700-6708. PMID: 31462438. PMCID: PMC6858960. DOI: 10.1158/1078-0432.CCR-19-1231.
6 Docking KM, Knijnik SR. Prospective longitudinal decline in cognitive-communication skills following treatment for childhood brain tumor[J]. Brain Inj, 2021, 35(11): 1472-1479. PMID: 34495783. DOI: 10.1080/02699052.2021.1970806.
7 Guilcher GMT, Rivard L, Huang JT, et al. Immune function in childhood cancer survivors: a Children's Oncology Group review[J]. Lancet Child Adolesc Health, 2021, 5(4): 284-294. PMID: 33600774. PMCID: PMC8725381. DOI: 10.1016/S2352-4642(20)30312-6.
8 Allodji RS, Haddy N, Vu-Bezin G, et al. Risk of subsequent colorectal cancers after a solid tumor in childhood: effects of radiation therapy and chemotherapy[J]. Pediatr Blood Cancer, 2019, 66(2): e27495. PMID: 30345604. DOI: 10.1002/pbc.27495.
9 George SA, Effinger KE, Meacham LR. Endocrine sequelae in childhood cancer survivors[J]. Endocrinol Metab Clin North Am, 2020, 49(4): 565-587. PMID: 33153668. DOI: 10.1016/j.ecl.2020.07.001.
10 Breneman JC, Donaldson SS, Constine L, et al. The Children's Oncology Group radiation oncology discipline: 15 years of contributions to the treatment of childhood cancer[J]. Int J Radiat Oncol Biol Phys, 2018, 101(4): 860-874. PMID: 29976498. PMCID: PMC6548440. DOI: 10.1016/j.ijrobp.2018.03.002.
11 Dugan KF, Hidde MC, Chard CA, et al. Exploring social ecological determinants of physical activity among adult survivors of childhood cancer[J]. J Adolesc Young Adult Oncol, 2021, 10(3): 316-325. PMID: 32598196. DOI: 10.1089/jayao.2019.0169.
12 Hildenbrand AK, Clawson KJ, Alderfer MA, et al. Coping with pediatric cancer: strategies employed by children and their parents to manage cancer-related stressors during treatment[J]. J Pediatr Oncol Nurs, 2011, 28(6): 344-354. PMID: 22194147. DOI: 10.1177/1043454211430823.
13 Palmer JD, Tsang DS, Tinkle CL, et al. Late effects of radiation therapy in pediatric patients and survivorship[J]. Pediatr Blood Cancer, 2021, 68Suppl 2:e28349. PMID: 33818893. DOI: 10.1002/pbc.28349.
14 Houghton PJ, Kurmasheva RT. Challenges and opportunities for childhood cancer drug development[J]. Pharmacol Rev, 2019, 71(4): 671-697. PMID: 31558580. PMCID: PMC6768308. DOI: 10.1124/pr.118.016972.
15 闫晓梅, 展晓宇, 张军. 儿童放射治疗定位的心理干预[J]. 中国医学装备, 2014, 11(9): 110-112. DOI: 10.3969/J.ISSN.1672-8270.2014.09.035.
16 何友安, 杨玉珍, 应薇, 等. 儿童肿瘤放射治疗计划执行过程的心理支持与质量保证[J]. 医学理论与实践, 2009, 22(1): 44-45. DOI: 10.3969/j.issn.1001-7585.2009.01.021.
17 T?rnqvist E, M?nsson ?, Hallstr?m I. Children having magnetic resonance imaging: a preparatory storybook and audio/visual media are preferable to anesthesia or deep sedation[J]. J Child Health Care, 2015, 19(3): 359-369. PMID: 24486815. DOI: 10.1177/1367493513518374.
18 Remes TM, Hovén E, Ritari N, et al. Neurocognitive impairment, employment, and social status in radiotherapy-treated adult survivors of childhood brain tumors[J]. Neurooncol Pract, 2021, 8(3): 266-277. PMID: 34055374. PMCID: PMC8153831. DOI: 10.1093/nop/npab004.
19 Tydings C, Kim A. Technology and precision therapy delivery in childhood cancer[J]. Curr Opin Pediatr, 2020, 32(1): 1-6. PMID: 31876621. DOI: 10.1097/MOP.0000000000000865.
20 Lu S, Wei J, Sun F, et al. Late sequelae of childhood and adolescent nasopharyngeal carcinoma survivors after radiation therapy[J]. Int J Radiat Oncol Biol Phys, 2019, 103(1): 45-51. PMID: 30244159. DOI: 10.1016/j.ijrobp.2018.09.015.
21 Inskip PD, Veiga LHS, Brenner AV, et al. Hypothyroidism after radiation therapy for childhood cancer: a report from the childhood cancer survivor study[J]. Radiat Res, 2018, 190(2):117-132. PMID: 29763379. PMCID: PMC6161838. DOI: 10.1667/RR14888.1.
22 Rahul M, Atif M, Tewari N, et al. Cancer-related radiation therapy in early childhood leading to root abnormality in multiple permanent teeth[J]. BMJ Case Rep, 2021, 14(8): e244770. PMID: 34413047. PMCID: PMC8378346. DOI: 10.1136/bcr-2021-244770.
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