Recent research on the association between signal transducer and activator of transcription 5 and childhood acute lymphoblastic leukemia

DUAN Yi-Fei; WEN Fei-Qiu

doi:10.7499/j.issn.1008-8830.2203117

PDF(3037 KB)

Chinese Journal of Contemporary Pediatrics ›› 2022, Vol. 24 ›› Issue (8) : 942-947. DOI: 10.7499/j.issn.1008-8830.2203117

REVIEW

Recent research on the association between signal transducer and activator of transcription 5 and childhood acute lymphoblastic leukemia

DUAN Yi-Fei, WEN Fei-Qiu

Author information +

History +

Abstract

Signal transducer and activator of transcription 5 (STAT5) can be involved in the processes such as cell proliferation, differentiation, apoptosis, and hematopoiesis, and its dysregulation is closely associated with the development and progression of malignant tumors including leukemia and may affect the treatment outcome and prognosis of pediatric patients. Identification of STAT5 can facilitate targeted therapy to improve the response rate of children with acute lymphoblastic leukemia. This article reviews the impact of STAT5 on the development/progression, targeted therapy strategies and the prognosis of childhood acute lymphoblastic leukemia.

Key words

Acute lymphoblastic leukemia / Signal transducer and activator of transcription 5 / Signal transduction / Child

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

DUAN Yi-Fei, WEN Fei-Qiu. Recent research on the association between signal transducer and activator of transcription 5 and childhood acute lymphoblastic leukemia[J]. Chinese Journal of Contemporary Pediatrics. 2022, 24(8): 942-947 https://doi.org/10.7499/j.issn.1008-8830.2203117