Objective To study the clinical features of children infected with the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods The medical data of 19 children who were diagnosed with SARS-CoV-2 Omicron variant infection from January 28 to March 3, 2022 in Hangzhou were retrospectively reviewed. Results Among the 19 children, there were 7 boys (37%) and 12 girls (63%), and their age ranged from 6 months to 16 years, with a median age of 2 years and 1 month. Most of these children were infants and young children (aged ≤3 years, accounting for 53%). Among these children, 11 (58%) were unvaccinated with SARS-CoV-2 vaccine and 8 (42%) were vaccinated with SARS-CoV-2 vaccine, and 3 children (16%) had a history of underlying diseases. All 19 children had a clear history of close contact with persons infected with SARS-CoV-2, and 10 children (53%) were involved in the cluster outbreak in a maternal and infant care center. In terms of clinical classification, 13 children (68%) had mild coronavirus disease 2019 (COVID-19) and 6 (32%) had common COVID-19, with no severe cases of COVID-19. The most common clinical symptoms were cough (100%) and fever (63%). The children with a normal peripheral white blood cell count accounted for 84%, and those with a normal lymphocyte count accounted for 68%. There were no significant abnormalities in platelet count, procalcitonin, liver function parameters (alanine aminotransferase and aspartate aminotransferase), and renal function parameters (creatinine and urea). Six children (32%) had obvious signs of pneumonia on chest CT. All 19 children were given symptomatic treatment, and 12 children (63%) were given aerosol inhalation of interferon α. All children were cured and discharged. Conclusions Children infected with Omicron variant strains are more common in infants and young children, with mild symptoms and good prognosis. Most of the children have a history of close contact with persons infected with SARS-CoV-2, and epidemic prevention and control should be strengthened in places with many infants and children, such as maternal and infant care centers.
Key words
Severe acute respiratory syndrome coronavirus 2 infection /
Omicron variant /
Clinical feature /
Child
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References
1 World Health Organization. WHO coronavirus (COVID-19) dashboard[EB/OL]. (2022-03-04)[2022-03-06]. https://covid19.who.int/.
2 World Health Organization. Tracking SARS-CoV-2 variants[EB/OL]. (2022-02-22)[2022-03-06]. https://www.who.int/en/activities/tracking-SARS-CoV-2-variants.
3 World Health Organization. Classification of Omicron (B.1.1.529): SARS-CoV-2 variant of concern[EB/OL]. (2021-11-26)[2022-03-06]. https://www.who.int/news/item/26-11-2021-classification-of-omicron-(b.1.1.529)-sars-cov-2-variant-of-concern.
4 World Health Organization. Statement on Omicron sublineage BA.2[EB/OL]. (2022-02-22)[2022-03-06]. https://www.who.int/news/item/22-02-2022-statement-on-omicron-sublineage-ba.2.
5 天津市卫生健康委员会. 天津从入境人员中检出新冠病毒奥密克戎变异株[EB/OL]. (2021-12-14)[2022-03-06]. https://wsjk.tj.gov.cn/ZTZL1/ZTZL750/YQFKZL9424/FKDT1207/202112/t20211214_5749144.html.
6 杭州发布. 关于杭州新增1例新冠肺炎确诊病例的情况通报[EB/OL]. (2022-01-26)[2022-03-06]. https://mp.weixin.qq.com/s/LiZFLA599wFuBDDLctUoTA.
7 杭州发布. 浙江通报杭州疫情最新情况![EB/OL]. (2022-01-27)[2022-03-06]. https://mp.weixin.qq.com/s/wb9fROvatdJZkaY1blSR5Q.
8 中华人民共和国国家卫生健康委员会. 新型冠状病毒肺炎诊疗方案(试行第八版修订版)[J]. 中华临床感染病杂志, 2021, 14(2): 81-88. DOI: 10.3760/cma.j.issn.1674-2397.2021.02.001.
9 中华医学会儿科学分会, 中华儿科杂志编辑委员会. 儿童2019新型冠状病毒感染的诊断与防治建议(试行第一版)[J]. 中华儿科杂志, 2020, 58(3): 169-174. PMID: 32135584. DOI: 10.3760/cma.j.issn.0578-1310.2020.03.001.
10 中华人民共和国国家卫生健康委员会. 儿童血细胞分析参考区间: WS/T 779-2021[S]. 北京: 中国标准出版社, 2021.
11 中华人民共和国国家卫生健康委员会. 儿童临床常用生化检验项目参考区间: WS/T 780-2021[S]. 北京: 中国标准出版社, 2021.
12 Cloete J, Kruger A, Masha M, et al. Paediatric hospitalisations due to COVID-19 during the first SARS-CoV-2 Omicron (B.1.1.529) variant wave in South Africa: a multicentre observational study[J]. Lancet Child Adolesc Health, 2022, 6(5): 294-302. PMID: 35189083. PMCID: PMC8856663. DOI: 10.1016/S2352-4642(22)00027-X.
13 杭州发布. 2月3日18时-24时, 杭州市新增1例新冠肺炎确诊病例[EB/OL]. (2022-02-04)[2022-03-06]. https://mp.weixin.qq.com/s/tfQBWDCqY-6WSGIyBi90lw.
14 黄春明, 胡中伟, 林菁, 等. 广州市儿童和青年新型冠状病毒Delta变异株感染患者临床特征[J]. 中国感染控制杂志, 2021, 20(11): 976-983. DOI: 10.12138/j.issn.1671-9638.20211781.
15 Lu X, Zhang L, Du H, et al. SARS-CoV-2 infection in children[J]. N Engl J Med, 2020, 382(17): 1663-1665. PMID: 32187458. PMCID: PMC7121177. DOI: 10.1056/NEJMc2005073.
16 CDC COVID-19 Response Team. Coronavirus disease 2019 in children—United States, February 12-April 2, 2020[J]. MMWR Morb Mortal Wkly Rep, 2020, 69(14): 422-426. PMID: 32271728. PMCID: PMC7147903. DOI: 10.15585/mmwr.mm6914e4.
17 蒋荣猛, 谢正德, 姜毅, 等. 儿童新型冠状病毒感染诊断、治疗和预防专家共识(第三版)[J]. 中华实用儿科临床杂志, 2021, 36(10): 721-732. DOI: 10.3760/cma.j.cn101070-20210226-00235.
18 Sun DW, Zhang D, Tian RH, et al. The underlying changes and predicting role of peripheral blood inflammatory cells in severe COVID-19 patients: a sentinel?[J]. Clin Chim Acta, 2020, 508: 122-129. PMID: 32417210. PMCID: PMC7224669. DOI: 10.1016/j.cca.2020.05.027.
19 Garcia-Beltran WF, Lam EC, Astudillo MG, et al. COVID-19-neutralizing antibodies predict disease severity and survival[J]. Cell, 2021, 184(2): 476-488.e11. PMID: 33412089. PMCID: PMC7837114. DOI: 10.1016/j.cell.2020.12.015.
20 岳勇, 梁娴, 毛毅, 等. 新型冠状病毒疫苗接种对成都市境外输入病例流行病学及临床特征的影响分析[J]. 中华流行病学杂志, 2021, 42(8): 1365-1370. PMID: 34814555. DOI:10.3760/cma.j.cn112338-20210330-00261.
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