Association between drug trough concentration and disease outcome before infliximab maintenance treatment in children with Crohn's disease

DENG Xing; YU Yi; WANG Xin-Qiong; LI Jia; XU Xu; XU Chun-Di; XIAO Yuan

doi:10.7499/j.issn.1008-8830.2205181

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Chinese Journal of Contemporary Pediatrics ›› 2022, Vol. 24 ›› Issue (11) : 1246-1251. DOI: 10.7499/j.issn.1008-8830.2205181

CLINICAL RESEARCH

Association between drug trough concentration and disease outcome before infliximab maintenance treatment in children with Crohn's disease

DENG Xing, YU Yi, WANG Xin-Qiong, LI Jia, XU Xu, XU Chun-Di, XIAO Yuan

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Abstract

Objective To study the association between infliximab trough level (IFX-TL) prior to maintenance treatment and disease outcome in children with Crohn's disease (CD). Methods A retrospective analysis was performed on 35 children with CD who received induction therapy with infliximab (IFX) and the measurement of IFX-TL before maintenance treatment from August 2018 to November 2021. Clinical data and laboratory markers at baseline and before maintenance treatment were collected, and the association between outcome and IFX-TL was analyzed. Results The clinical remission group, endoscopic remission group, and combined remission group had a significantly higher IFX-TL level than the corresponding non-remission groups (P<0.05), and there was no significant difference in the IFX-TL level between the biological remission and non-biological remission groups (P>0.05). The receiver operating characteristic (ROC) curve showed that IFX-TL had an area under the ROC curve of 0.959 (95%CI: 0.894-1) in predicting clinical remission, with a sensitivity of 90% and a specificity of 100% at the optimal cutoff value of 2.3 μg/mL (P<0.001). Conclusions Among children with CD receiving infliximab induction therapy, the children achieving clinical and endoscopic remission before maintenance treatment tend to have a higher level of IFX-TL. IFX-TL has a certain predictive value for clinical remission.

Key words

Crohn's disease / Infliximab / Therapeutic drug monitoring / Pediatric Crohn's disease activity index / Simple Endoscopic Score for Crohn's disease / Child

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DENG Xing, YU Yi, WANG Xin-Qiong, LI Jia, XU Xu, XU Chun-Di, XIAO Yuan. Association between drug trough concentration and disease outcome before infliximab maintenance treatment in children with Crohn's disease[J]. Chinese Journal of Contemporary Pediatrics. 2022, 24(11): 1246-1251 https://doi.org/10.7499/j.issn.1008-8830.2205181

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