Recent studies on dilated cardiomyopathy caused by TTN mutations in children

ZHENG Kui; LOU Mei-Na

doi:10.7499/j.issn.1008-8830.2208163

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Chinese Journal of Contemporary Pediatrics ›› 2023, Vol. 25 ›› Issue (2) : 217-222. DOI: 10.7499/j.issn.1008-8830.2208163

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Recent studies on dilated cardiomyopathy caused by TTN mutations in children

ZHENG Kui, LOU Mei-Na

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Abstract

The mutations of TTN gene that encodes titin are the most common mutation type among the genetic causes of dilated cardiomyopathy (DCM). This article reviews the worldwide studies on potential molecular pathogenesis (transcription, post-translational modification, etc.), clinical phenotypes, and gene therapies of pediatric DCM caused by TTN mutations, with the hope of providing a reference for the precision treatment of pediatric DCM caused by TTN mutations.

Key words

Dilated cardiomyopathy / TTN gene / Titin / Treatment / Child

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ZHENG Kui, LOU Mei-Na. Recent studies on dilated cardiomyopathy caused by TTN mutations in children[J]. Chinese Journal of Contemporary Pediatrics. 2023, 25(2): 217-222 https://doi.org/10.7499/j.issn.1008-8830.2208163

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