Expression and significance of jumonji domain-containing protein 2B and hypoxia inducible factor-1α in non-Hodgkin lymphoma tissues in children

DIAO Yu-Qiao; WANG Jian; ZHU Xiu-Li; CHEN Jian; ZHENG Yu; JIANG Lian; LIU Yue-Ping; DAI Ruo-Heng; YAN Yi-Wei

doi:10.7499/j.issn.1008-8830.2305025

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Chinese Journal of Contemporary Pediatrics ›› 2023, Vol. 25 ›› Issue (11) : 1150-1155. DOI: 10.7499/j.issn.1008-8830.2305025

CLINICAL RESEARCH

Expression and significance of jumonji domain-containing protein 2B and hypoxia inducible factor-1α in non-Hodgkin lymphoma tissues in children

DIAO Yu-Qiao, WANG Jian, ZHU Xiu-Li, CHEN Jian, ZHENG Yu, JIANG Lian, LIU Yue-Ping, DAI Ruo-Heng, YAN Yi-Wei

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Abstract

Objective To investigate the expression and significance of jumonji domain-containing protein 2B (JMJD2B) and hypoxia-inducible factor-1α (HIF-1α) in non-Hodgkin's lymphoma (NHL) tissues in children. Methods Immunohistochemistry was used to detect the expression of JMJD2B and HIF-1α in lymph node tissue specimens from 46 children with NHL (observation group) and 24 children with reactive hyperplasia (control group). The relationship between JMJD2B and HIF-1α expression with clinicopathological characteristics and prognosis in children with NHL, as well as the correlation between JMJD2B and HIF-1α expression in NHL tissues, were analyzed. Results The positive expression rates of JMJD2B (87% vs 21%) and HIF-1α (83% vs 42%) in the observation group were higher than those in the control group (P<0.05). The expression of JMJD2B and HIF-1α was correlated with serum lactate dehydrogenase levels and the risk of international prognostic index in children with NHL (P<0.05). The expression of JMJD2B was positively correlated with the HIF-1α expression in children with NHL (r_s=0.333, P=0.024). Conclusions JMJD2B and HIF-1α are upregulated in children with NHL, and they may play a synergistic role in the development of pediatric NHL. JMJD2B can serve as a novel indicator for auxiliary diagnosis, evaluation of the severity, treatment guidance, and prognosis assessment in pediatric NHL.

Key words

Non-Hodgkin's lymphoma / Jumonji domain-containing protein 2B / Hypoxia-inducible factor-1α / Clinicopathological characteristic / Prognosis / Child

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DIAO Yu-Qiao, WANG Jian, ZHU Xiu-Li, CHEN Jian, ZHENG Yu, JIANG Lian, LIU Yue-Ping, DAI Ruo-Heng, YAN Yi-Wei. Expression and significance of jumonji domain-containing protein 2B and hypoxia inducible factor-1α in non-Hodgkin lymphoma tissues in children[J]. Chinese Journal of Contemporary Pediatrics. 2023, 25(11): 1150-1155 https://doi.org/10.7499/j.issn.1008-8830.2305025

References

1 高怡瑾. 儿童淋巴瘤一线治疗、挽救治疗和新治疗[J]. 中国小儿血液与肿瘤杂志, 2020, 25(1): 1-3. DOI: 10.3969/j.issn.1673-5323.2020.01.001.
2 Attarbaschi A, Abla O, Arias Padilla L, et al. Rare non-Hodgkin lymphoma of childhood and adolescence: a consensus diagnostic and therapeutic approach to pediatric-type follicular lymphoma, marginal zone lymphoma, and nonanaplastic peripheral T-cell lymphoma[J]. Pediatr Blood Cancer, 2020, 67(8): e28416. PMID: 32452165. DOI: 10.1002/pbc.28416.
3 Liu R, Wu J, Guo H, et al. Post-translational modifications of histones: mechanisms, biological functions, and therapeutic targets[J]. MedComm (2020), 2023, 4(3): e292. PMID: 37220590. PMCID: PMC10200003. DOI: 10.1002/mco2.292.
4 Illam SP, Kandiyil SP, Raghavamenon AC. Targeting histone onco- modifications using plant-derived products[J]. Curr Drug Targets, 2021, 22(11): 1317-1331. PMID: 33461463. DOI: 10.2174/1389450122666210118150716.
5 Chen L, Fu L, Kong X, et al. Jumonji domain-containing protein 2B silencing induces DNA damage response via STAT3 pathway in colorectal cancer[J]. Br J Cancer, 2014, 110(4): 1014-1026. PMID: 24473398. PMCID: PMC3929886. DOI: 10.1038/bjc.2013.808.
6 Lu JW, Ho YJ, Lin LI, et al. JMJD2B as a potential diagnostic immunohistochemical marker for hepatocellular carcinoma: a tissue microarray-based study[J]. Acta Histochem, 2015, 117(1): 14-19. PMID: 25533242. DOI: 10.1016/j.acthis.2014.10.002.
7 Yang J, Jubb AM, Pike L, et al. The histone demethylase JMJD2B is regulated by estrogen receptor alpha and hypoxia, and is a key mediator of estrogen induced growth[J]. Cancer Res, 2010, 70(16): 6456-6466. PMID: 20682797. PMCID: PMC4261152. DOI: 10.1158/0008-5472.CAN-10-0413.
8 Zhao L, Li W, Zang W, et al. JMJD2B promotes epithelial-mesenchymal transition by cooperating with β-catenin and enhances gastric cancer metastasis[J]. Clin Cancer Res, 2013, 19(23): 6419-6429. PMID: 24077348. DOI: 10.1158/1078-0432.CCR-13-0254.
9 朱培, 唐梦燕, 闫东梅. HIF-1α及其相关信号转导通路在疾病中的研究进展[J]. 中国免疫学杂志, 2020, 36(13): 1650-1653. DOI: 10.3969/j.issn.1000-484X.2020.13.022.
10 张庭凤, 蔡正文, 孙蔚亮, 等. HIF-1α、HIF-2α和GLUT-1在非霍奇金淋巴瘤中的表达及其临床意义[J]. 广西医科大学学报, 2022, 39(3): 475-479. DOI: 10.16190/j.cnki.45-1211/r.2022.03.022.
11 Swerdlow SH, Campo E, Harris NL, et al. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues[M]. 4th ed. Lyon: IARC Press, 2017.
12 黄行志, 洪亚然, 沈丽达. 儿童青少年非霍奇金淋巴瘤的研究进展[J]. 医学综述, 2014, 20(6): 1043-1046. DOI: 10.3969/j.issn.1006-2084.2014.06.028.
13 Diao W, Zheng J, Li Y, et al. Targeting histone demethylases as a potential cancer therapy (review)[J]. Int J Oncol, 2022, 61(3): 103. PMID: 35801593. DOI: 10.3892/ijo.2022.5393.
14 Toyokawa G, Cho HS, Iwai Y, et al. The histone demethylase JMJD2B plays an essential role in human carcinogenesis through positive regulation of cyclin-dependent kinase 6[J]. Cancer Prev Res (Phila), 2011, 4(12): 2051-2061. PMID: 21930796. DOI: 10.1158/1940-6207.CAPR-11-0290.
15 苗晓红. JMJD2B和HPIP在宫颈癌中的表达及其与临床预后的关系[J]. 中南医学科学杂志, 2022, 50(4): 588-591. DOI: 10.15972/j.cnki.43-1509/r.2022.04.031.
16 洪苓苓, 马旭东, 黄轶群. PHI对Burkitt淋巴瘤Daudi细胞株组蛋白甲基化和乙酰化调控的实验研究[J]. 中国实验血液学杂志, 2011, 19(1): 105-108. PMID: 21362232.
17 侯思宇, 陈秀玮. JMJD2B蛋白结构功能及在恶性肿瘤发生发展中的研究进展[J]. 实用肿瘤学杂志, 2018, 32(3): 250-253. DOI: 10.11904/j.issn.1002-3070.2018.03.012.
18 赵冉, 刘星辰, 吴胜胜, 等. 磷脂酰肌醇-3激酶抑制剂在复发/难治性滤泡淋巴瘤研究中的新进展[J]. 国际输血及血液学杂志, 2021, 44(1): 48-53. DOI: 10.3760/cma.j.cn511693-20200609-00122.
19 Liu OH, Kiema M, Beter M, et al. Hypoxia-mediated regulation of histone demethylases affects angiogenesis-associated functions in endothelial cells[J]. Arterioscler Thromb Vasc Biol, 2020, 40(11): 2665-2677. PMID: 32938217. DOI: 10.1161/ATVBAHA.120.315214.
20 周航, 桑威, 徐开林. 血管内皮生长因子在淋巴瘤中的研究进展[J]. 白血病·淋巴瘤, 2019, 28(6): 381-384. DOI:10.3760/cma.j.issn.1009-9921.2019.06.016.
21 黄灵娟, 贾永廉, 李瑞花, 等. 恶性血液病患者乳酸脱氢酶水平的临床分析[J]. 临床医学研究与实践, 2020, 5(1): 47-48. DOI: 10.19347/j.cnki.2096-1413.202001018.
22 舒本富, 燕长花, 罗焱梅. 非霍奇金淋巴瘤患者检测乳酸脱氢酶以及β2-微球蛋白的临床价值[J]. 实验与检验医学, 2017, 35(2): 248-250. DOI: 10.3969/j.issn.1674-1129.2017.02.036.
23 Bur H, Haapasaari KM, Turpeenniemi-Hujanen T, et al. Strong KDM4B and KDM4D expression associates with radioresistance and aggressive phenotype in classical hodgkin lymphoma[J]. Anticancer Res, 2016, 36(9): 4677-4683. PMID: 27630312. DOI: 10.21873/anticanres.11020.
24 Nie W, Luo X, Lu D, et al. Casein kinase?1α?1 is involved in the progression of glioblastoma through HIF-1α-mediated autophagy[J]. J Neurophysiol, 2022, 128(4): 910-918. PMID: 36102564. DOI: 10.1152/jn.00316.2022.
25 Fan Y, Ou L, Fan J, et al. PLCε regulates metabolism and metastasis signaling via HIF-1α/MEK/ERK pathway in prostate cancer[J]. J Cell Physiol, 2020, 235(11): 8546-8557. PMID: 32383180. DOI: 10.1002/jcp.29698.
26 Liu X, Gao Z, Wang X, et al. Parthenolide targets NF-κB (P50) to inhibit HIF-1α-mediated metabolic reprogramming of HCC[J]. Aging (Albany NY), 2022, 14(20): 8346-8356. PMID: 36260873. PMCID: PMC9648796. DOI: 10.18632/aging.204339.
27 Song H, Qiu Z, Wang Y, et al. HIF-1α/YAP signaling rewrites glucose/Iodine metabolism program to promote papillary thyroid cancer progression[J]. Int J Biol Sci, 2023, 19(1): 225-241. PMID: 36594102. PMCID: PMC9760428. DOI: 10.7150/ijbs.75459.
28 Wang M, Wang W, Ding J, et al. Downregulation of Rab17 promotes cell proliferation and invasion in non-small cell lung cancer through STAT3/HIF-1α/VEGF signaling[J]. Thorac Cancer, 2020, 11(2): 379-388. PMID: 31841274. PMCID: PMC6997001. DOI: 10.1111/1759-7714.13278.
29 Zheng Y, Chen H, Zhao Y, et al. Knockdown of FBXO22 inhibits melanoma cell migration, invasion and angiogenesis via the HIF-1α/VEGF pathway[J]. Invest New Drugs, 2020, 38(1): 20-28. PMID: 30887251. DOI: 10.1007/s10637-019-00761-z.
30 蒋洁, 黎岳南, 牛海艳, 等. HIF-1α在非霍奇金淋巴瘤中的表达及其与肿瘤细胞凋亡和增殖的关系[J]. 海南医学院学报, 2007, 13(6): 523-526. DOI: 10.13210/j.cnki.jhmu.2007.06.034.
31 Bhalla S, Evens AM, Prachand S, et al. Paradoxical regulation of hypoxia inducible factor-1α (HIF-1α) by histone deacetylase inhibitor in diffuse large B-cell lymphoma[J]. PLoS One, 2013, 8(11): e81333. PMID: 24312289. PMCID: PMC3842257. DOI: 10.1371/journal.pone.0081333.
32 Zhang H, Chen Z, Miranda RN, et al. Bifurcated BACH2 control coordinates mantle cell lymphoma survival and dispersal during hypoxia[J]. Blood, 2017, 130(6): 763-776. PMID: 28592433. PMCID: PMC5553575. DOI: 10.1182/blood-2017-02-767293.
33 张晓侠, 白涛敏, 樊莹丽. HIF-1α、VEGF在儿童非霍杰金淋巴瘤组织中的表达及意义[J]. 临床医学研究与实践, 2017, 2(29): 5-7. DOI: 10.19347/j.cnki.2096-1413.201729002.
34 Hernandez-Luna MA, Rocha-Zavaleta L, Vega MI, et al. Hypoxia inducible factor-1α induces chemoresistance phenotype in non-Hodgkin lymphoma cell line via up-regulation of Bcl-xL[J]. Leuk Lymphoma, 2013, 54(5): 1048-1055. PMID: 23013270. DOI: 10.3109/10428194.2012.733874.
35 苏玉璇, 夏瑞祥. HIF-1α和Bmi-1在弥漫大B细胞淋巴瘤中的表达及意义[J]. 蚌埠医学院学报, 2012, 37(3): 280-283. DOI: 10.13898/j.cnki.issn.1000-2200.2012.03.013.
36 胡露露, 刘慧, 张晋, 等. 口腔颌面部淋巴瘤患者HIF-1α及CD44v6的表达与侵袭转移的关系分析[J]. 吉林医学, 2017, 38(10): 1841-1844. DOI: 10.3969/j.issn.1004-0412.2017.10.016.
37 Toyokawa G, Taguchi K, Edagawa M, et al. The prognostic impact of jumonji domain-containing 2B in patients with resected lung adenocarcinoma[J]. Anticancer Res, 2016, 36(9): 4841-4846. PMID: 27630338. DOI: 10.21873/anticanres.11046.
38 吴宏增, 赵嘉政, 赵祎, 等. 横纹肌肉瘤组织中JMJD2B和HIF-1α的表达及其对预后的意义[J]. 肿瘤防治研究, 2021, 48(7): 699-703. DOI: 10.3971/j.issn.1000-8578.2021.21.0030.
39 Fu L, Chen L, Yang J, et al. HIF-1α-induced histone demethylase JMJD2B contributes to the malignant phenotype of colorectal cancer cells via an epigenetic mechanism[J]. Carcinogenesis, 2012, 33(9): 1664-1673. PMID: 22745382. DOI: 10.1093/carcin/bgs217.
40 Liu X, Zhang Q, Zhao Y, et al. Association of JMJD2B and hypoxia-inducible factor 1 expressions with poor prognosis in osteosarcoma[J]. Anal Cell Pathol (Amst), 2020, 2020: 2563208. PMID: 32802732. PMCID: PMC7415079. DOI: 10.1155/2020/2563208.
41 马金华, 胡晓东, 张晓玲, 等. JMJD2B和HIF-1α在喉鳞状细胞癌中的表达及其与预后的相关性研究[J]. 诊断病理学杂志, 2022, 29(8): 728-732. DOI: 10.3969/j.issn.1007-8096.2022.08.012.
42 郭凯旋, 李海杰, 陶德定, 等. 低氧诱导因子-1α通过调控组蛋白去甲基化酶4B影响结直肠肿瘤细胞的增殖能力[J]. 中华实验外科杂志, 2019, 36(9): 1598-1600. DOI: 10.3760/cma.j.issn.1001-9030.2019.09.021.