Clinical practice guidelines for meropenem therapy in neonatal sepsis (2024)

Guideline Development Group of Clinical Practice Guidelines for Meropenem Therapy in Neonatal Sepsis; PekingUniversity Third Hospital; Editorial Department of Chinese Journal of Contemporary Pediatric

doi:10.7499/j.issn.1008-8830.2309059

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Chinese Journal of Contemporary Pediatrics ›› 2024, Vol. 26 ›› Issue (2) : 107-117. DOI: 10.7499/j.issn.1008-8830.2309059

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Clinical practice guidelines for meropenem therapy in neonatal sepsis (2024)

Guideline Development Group of Clinical Practice Guidelines for Meropenem Therapy in Neonatal Sepsis; PekingUniversity Third Hospital; Editorial Department of Chinese Journal of Contemporary Pediatrics

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Abstract

Meropenem is one of the most widely used special-grade antimicrobial agents in the treatment of neonatal sepsis. However, its irrational use has led to an increasingly severe problem of bacterial multidrug resistance. The guideline was developed following standardized methods and procedures, and provides 12 recommendations specifically addressing 9 clinical issues. The recommendations cover various aspects of meropenem use in neonates, including timing of administration, recommended dosage, extended infusion, monitoring and assessment, antimicrobial adjustment strategies, treatment duration, and treatment strategies for carbapenem-resistant Enterobacteriaceae infections. The aim of the guideline is to provide evidence-based recommendations and guidance for the rational use of meropenem in neonates with sepsis.

Key words

Meropenem / Sepsis / Clinical practice guideline / Neonate

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Guideline Development Group of Clinical Practice Guidelines for Meropenem Therapy in Neonatal Sepsis; PekingUniversity Third Hospital; Editorial Department of Chinese Journal of Contemporary Pediatric. Clinical practice guidelines for meropenem therapy in neonatal sepsis (2024)[J]. Chinese Journal of Contemporary Pediatrics. 2024, 26(2): 107-117 https://doi.org/10.7499/j.issn.1008-8830.2309059

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