人绒毛膜促性腺激素激发试验在性发育异常儿童中的诊断作用评估

doi:10.7499/j.issn.1008-8830.2309090

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Abstract Objective To investigate the value of the human chorionic gonadotropin (hCG) stimulation test in the diagnosis of disorder of sexual development (DSD) in children. Methods A retrospective analysis was conducted on 132 children with DSD. According to the karyotype, they were divided into three groups: 46,XX group (n=10), 46,XY group (n=87), and sex chromosome abnormality group (n=35). The above groups were compared in terms of sex hormone levels before and after hCG stimulation test, and the morphological manifestation of the impact of testicular tissue on the results of the hCG stimulation test was analyzed. Results There was no significant difference in the multiple increase of testosterone after stimulation among the three groups (P>0.05). In the 46,XY group, the children with 5α-reductase type 2 deficiency had a testosterone-to-dihydrotestosterone ratio higher than that of the 46,XY DSD children with other causes. Morphological analysis showed that DSD children with testicular tissue demonstrated a significantly higher multiple increase in testosterone after stimulation compared to children without testicular tissue (P<0.05). Conclusions The hCG stimulation test has an important value in assessing the presence and function of testicular interstitial cells in children with different types of DSD, and it is recommended to perform the hCG stimulation test for DSD children with unclear gonadal type.

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	Articles by authors
	LIANG Cui-Li
	LIU Guo-Chang
	CHENG Jing
	NIU Hui-Lin
	FU Wen
	ZHANG Li-Yu
	JIA Wei
	ZHANG Wen
	LIU Li

Key words： Disorder of sexual development Human chorionic gonadotropins stimulation test Testicular interstitial cell Testosterone Child

Received: 18 September 2023

Cite this article:

LIANG Cui-Li,LIU Guo-Chang,CHENG Jing et al. Value of the human chorionic gonadotropin stimulation test in the diagnosis of disorder of sexual development in children[J]. CJCP, 2024, 26(2): 158-163.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2309090 OR http://www.zgddek.com/EN/Y2024/V26/I2/158

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