Research advances on B-cell activating factor and its targeted agents in inflammatory bowel disease

LI Lin; LIU Hai-Yan; WANG Li-Jun

doi:10.7499/j.issn.1008-8830.2309126

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Chinese Journal of Contemporary Pediatrics ›› 2024, Vol. 26 ›› Issue (3) : 315-320. DOI: 10.7499/j.issn.1008-8830.2309126

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Research advances on B-cell activating factor and its targeted agents in inflammatory bowel disease

LI Lin, LIU Hai-Yan, WANG Li-Jun

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Abstract

B-cell activating factor (BAFF), a critical regulator of B cells, is involved in various autoimmune diseases. Inflammatory bowel disease (IBD) is a group of chronic and recurrent intestinal inflammatory disorders with unclear etiology, and its global incidence has been increasing in recent years. Abnormal immune responses triggered by multiple factors are closely related to the pathogenesis of IBD. Previous studies have confirmed the association of B-cell abnormal activation and increased production of autoantibodies with the development of ulcerative colitis. However, the involvement of BAFF in the mechanisms of IBD remains unclear. This review summarizes the potential role of BAFF in the pathogenesis of IBD and provides an overview of targeted therapies on BAFF in IBD, aiming to contribute insights for targeted treatments of IBD.

Key words

Inflammatory bowel disease / B-cell activating factor / Targeted therapy

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LI Lin, LIU Hai-Yan, WANG Li-Jun. Research advances on B-cell activating factor and its targeted agents in inflammatory bowel disease[J]. Chinese Journal of Contemporary Pediatrics. 2024, 26(3): 315-320 https://doi.org/10.7499/j.issn.1008-8830.2309126

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