单时相GnRH激发试验对不同体重指数女童中枢性性早熟诊断价值的研究

doi:10.7499/j.issn.1008-8830.2312011

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Abstract Objective To investigate the value of single-phase gonadotropin releasing hormone (GnRH) stimulation test in the diagnosis of central precocious puberty (CPP) in girls with different levels of body mass index (BMI). Methods A retrospective analysis was performed for the data of 760 girls with breast development before 7.5 years of age who attended the Third Affiliated Hospital of Zhengzhou University from January 2017 to August 2023. According to the results of GnRH stimulation test and clinical manifestations, they were divided into a CPP group (297 girls) and a non-CPP group (463 girls). According to the values of BMI, the girls were divided into a normal weight group (540 girls), an overweight group (116 girls), and an obese group (104 girls). The receiver operating characteristic (ROC) curve was used to investigate the value of single-phase GnRH stimulation test in the diagnosis of CPP in girls with different levels of BMI. Results Luteinizing hormone (LH)/follicle-stimulating hormone at 30 minutes after GnRH stimulation had an area under the curve (AUC) of 0.985 in the diagnosis of CPP, which was higher than the AUC at 0, 60, and 90 minutes (P<0.05). LH at 30 minutes had a similar diagnostic value to LH at 60 minutes (P>0.05). LH at 30 minutes was negatively correlated with BMI and BMI-Z value (P<0.05).The AUC for diagnosing CPP in normal weight, overweight, and obese girls at 30 minutes LH was 0.952, 0.965, and 0.954, respectively (P<0.05). Conclusions The 30-minute GnRH stimulation test has a good value in the diagnosis of CPP in girls with different levels of BMI and is expected to replace the traditional GnRH stimulation test, but the influence of BMI on LH level should be taken seriously.

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	WANG Wei
	WANG Yi-Fan
	XIAO Ya
	ZHANG Hong-Ru
	SUN Jun
	SHI Wen-Hui
	LI Jin-Bo

Key words： Central precocious puberty Body mass index Luteinizing hormone Gonadotropin-releasing hormone stimulation test Girl

Received: 04 December 2023

About author:: ，E-mail：weiwang169@126.com；

Cite this article:

WANG Wei,WANG Yi-Fan,XIAO Ya et al. Value of single-phase gonadotropin-releasing hormone stimulation test in diagnosis of central precocious puberty in girls with different levels of body mass index[J]. CJCP, 2024, 26(6): 592-598.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2312011 OR http://www.zgddek.com/EN/Y2024/V26/I6/592

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