Recent research on gene polymorphisms and genetic susceptibility of neonatal sepsis

GAO Jing; SHU Jian-Bo; LIU Yang

doi:10.7499/j.issn.1008-8830.2401065

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Chinese Journal of Contemporary Pediatrics ›› 2024, Vol. 26 ›› Issue (8) : 879-886. DOI: 10.7499/j.issn.1008-8830.2401065

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Recent research on gene polymorphisms and genetic susceptibility of neonatal sepsis

GAO Jing, SHU Jian-Bo, LIU Yang

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Abstract

Neonatal sepsis is a common and severe infectious disease with a high mortality rate. Its pathogenesis is complex, lacks specific manifestations, and has a low positive culture rate, making early diagnosis and personalized treatment still a challenge for clinicians. Epidemiological studies on twins have shown that genetic factors are associated with neonatal sepsis. Gene polymorphisms are closely related to susceptibility, disease development, and prognosis. This article provides a review of gene polymorphisms related to neonatal sepsis, including interleukins, tumor necrosis factor, Toll-like receptors, NOD-like receptors, CD14, triggering receptor expressed on myeloid cells-1, mannose-binding lectin, and other immune proteins, aiming to promote precision medicine for this disease.

Key words

Sepsis / Genetic susceptibility / Gene polymorphism / Single nucleotide polymorphism / Neonate

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GAO Jing, SHU Jian-Bo, LIU Yang. Recent research on gene polymorphisms and genetic susceptibility of neonatal sepsis[J]. Chinese Journal of Contemporary Pediatrics. 2024, 26(8): 879-886 https://doi.org/10.7499/j.issn.1008-8830.2401065

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