基因多态性与新生儿败血症的遗传易感性研究进展

doi:10.7499/j.issn.1008-8830.2401065

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Abstract Neonatal sepsis is a common and severe infectious disease with a high mortality rate. Its pathogenesis is complex, lacks specific manifestations, and has a low positive culture rate, making early diagnosis and personalized treatment still a challenge for clinicians. Epidemiological studies on twins have shown that genetic factors are associated with neonatal sepsis. Gene polymorphisms are closely related to susceptibility, disease development, and prognosis. This article provides a review of gene polymorphisms related to neonatal sepsis, including interleukins, tumor necrosis factor, Toll-like receptors, NOD-like receptors, CD14, triggering receptor expressed on myeloid cells-1, mannose-binding lectin, and other immune proteins, aiming to promote precision medicine for this disease.

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	GAO Jing
	SHU Jian-Bo
	LIU Yang

Key words： Sepsis Genetic susceptibility Gene polymorphism Single nucleotide polymorphism Neonate

Received: 15 January 2024

Corresponding Authors: Liu Y，E-mail：etyyly@163.com E-mail: etyyly@163.com

Cite this article:

GAO Jing,SHU Jian-Bo,LIU Yang. Recent research on gene polymorphisms and genetic susceptibility of neonatal sepsis[J]. CJCP, 2024, 26(8): 879-886.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2401065 OR http://www.zgddek.com/EN/Y2024/V26/I8/879

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