Expert consensus on enteral nutrition management for preterm infants in special situations (2024)

Nutritional Committee of Neonatology Branch of Chinese Medical Doctor Association; Preterm Committee of Neonatology Branch of Chinese Medical Doctor Association; Editorial Committee of Chinese Journal of Contemporary Pediatrics

Chinese Journal of Contemporary Pediatrics ›› 2024, Vol. 26 ›› Issue (7) : 665-676.

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Chinese Journal of Contemporary Pediatrics ›› 2024, Vol. 26 ›› Issue (7) : 665-676. DOI: 10.7499/j.issn.1008-8830.2402040
STANDARD·PROTOCOL·GUIDELINE

Expert consensus on enteral nutrition management for preterm infants in special situations (2024)

  • Nutritional Committee of Neonatology Branch of Chinese Medical Doctor Association; Preterm Committee of Neonatology Branch of Chinese Medical Doctor Association; Editorial Committee of Chinese Journal of Contemporary Pediatrics
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Abstract

Establishing enteral nutrition after the birth of preterm infants presents numerous challenges, particularly for those in special situations. Various disease factors and medical interventions impede the establishment of enteral feeding, leading to conflicts and controversies regarding feeding goals, feeding methods, and the challenges and solutions faced by these infants. A critical issue for clinical physicians is how to safely and promptly establish enteral nutrition to achieve full enteral feeding as quickly as possible. The consensus formulation working group, based on both domestic and overseas research, adopted the Grading of Recommendations Assessment, Development and Evaluation, and formed an expert consensus on enteral nutrition management for preterm infants in special situations. This consensus provides 14 recommendations for 9 common special situations, aiming to offer guidance on enteral nutrition management for preterm infants to improve their short and long-term outcomes. Citation:Chinese Journal of Contemporary Pediatrics, 2024, 26(7): 665-676

Key words

Enteral nutrition / Special situation / Fasting / Expert consensus / Preterm infant

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Nutritional Committee of Neonatology Branch of Chinese Medical Doctor Association; Preterm Committee of Neonatology Branch of Chinese Medical Doctor Association; Editorial Committee of Chinese Journal of Contemporary Pediatrics. Expert consensus on enteral nutrition management for preterm infants in special situations (2024)[J]. Chinese Journal of Contemporary Pediatrics. 2024, 26(7): 665-676 https://doi.org/10.7499/j.issn.1008-8830.2402040

References

1 Zhao T, Feng HM, Caicike B, et al. Investigation into the current situation and analysis of the factors influencing extrauterine growth retardation in preterm infants[J]. Front Pediatr, 2021, 9: 643387. PMID: 33996689. PMCID: PMC8119632. DOI: 10.3389/fped.2021.643387.
2 王琳, 赵小朋, 刘辉娟, 等. 基于循证的标准化喂养方案可以帮助极早产儿/极低出生体重儿尽早达到全肠道喂养[J]. 中国当代儿科杂志, 2022, 24(6): 648-653. PMID: 35762431. PMCID: PMC9250396. DOI: 10.7499/j.issn.1008-8830.2202121.
3 de Waard M, Li Y, Zhu Y, et al. Time to full enteral feeding for very low-birth-weight infants varies markedly among hospitals worldwide but may not be associated with incidence of necrotizing enterocolitis: the NEOMUNE-NeoNutriNet cohort study[J]. JPEN J Parenter Enteral Nutr, 2019, 43(5): 658-667. PMID: 30465333. PMCID: PMC6531355. DOI: 10.1002/jpen.1466.
4 Schneider J, Fischer Fumeaux CJ, Duerden EG, et al. Nutrient intake in the first two weeks of life and brain growth in preterm neonates[J]. Pediatrics, 2018, 141(3): e20172169. PMID: 29440285. DOI: 10.1542/peds.2017-2169.
5 Schünemann H, Bro?ek J, Guyatt G, et al. GRADE Handbook[EB/OL]. [2020-07-16]. https://gdt.gradepro.org/app/handbook/handbook.html.
6 GRADEpro GDT. GRADE your evidence and improve your guideline development in health care[EB/OL]. [2020-07-10]. https://www.gradepro.org/.
7 BalshemH, HelfandM, SchünemannHJ, 等. GRADE指南: Ⅲ.证据质量分级[J]. 中国循证医学杂志, 2011, 11(4): 451-455. DOI: 10.3969/j.issn.1672-2531.2011.04.017.
8 Bernstein IM, Horbar JD, Badger GJ, et al. Morbidity and mortality among very-low-birth-weight neonates with intrauterine growth restriction. The Vermont Oxford Network[J]. Am J Obstet Gynecol, 2000, 182(1 Pt 1): 198-206. PMID: 10649179. DOI: 10.1016/s0002-9378(00)70513-8.
9 Dorling J, Kempley S, Leaf A. Feeding growth restricted preterm infants with abnormal antenatal Doppler results[J]. Arch Dis Child Fetal Neonatal Ed, 2005, 90(5): F359-F363. PMID: 16113150. PMCID: PMC1721930. DOI: 10.1136/adc.2004.060350.
10 Karagianni P, Briana DD, Mitsiakos G, et al. Early versus delayed minimal enteral feeding and risk for necrotizing enterocolitis in preterm growth-restricted infants with abnormal antenatal Doppler results[J]. Am J Perinatol, 2010, 27(5): 367-373. PMID: 20013579. DOI: 10.1055/s-0029-1243310.
11 Leaf A, Dorling J, Kempley S, et al. Early or delayed enteral feeding for preterm growth-restricted infants: a randomized trial[J]. Pediatrics, 2012, 129(5): e1260-e1268. PMID: 22492770. DOI: 10.1542/peds.2011-2379.
12 Abdelmaaboud M, Mohammed A. Early versus late minimal enteral feeding in weeks preterm growth-restricted neonates with abnormal antenatal doppler studies[J]. J Matern Fetal Neonatal Med, 2012. Epub ahead of print. PMID: 23211122. DOI: 10.3109/14767058.2012.695821.
13 Dutta S, Singh B, Chessell L, et al. Guidelines for feeding very low birth weight infants[J]. Nutrients, 2015, 7(1): 423-442. PMID: 25580815. PMCID: PMC4303848. DOI: 10.3390/nu7010423.
14 Sayari AJ, Tashiro J, Sola JE, et al. Blood transfusions, increased rates of surgical NEC, and lower survival: a propensity score-matched analysis[J]. J Pediatr Surg, 2016, 51(6): 927-931. PMID: 26995520. DOI: 10.1016/j.jpedsurg.2016.02.052.
15 Sood BG, Rambhatla A, Thomas R, et al. Decreased hazard of necrotizing enterocolitis in preterm neonates receiving red cell transfusions[J]. J Matern Fetal Neonatal Med, 2016, 29(5): 737-744. PMID: 25731658. DOI: 10.3109/14767058.2015.1016422.
16 Patel RM, Knezevic A, Shenvi N, et al. Association of red blood cell transfusion, anemia, and necrotizing enterocolitis in very low-birth-weight infants[J]. JAMA, 2016, 315(9): 889-897. PMID: 26934258. PMCID: PMC4805423. DOI: 10.1001/jama.2016.1204.
17 Balegar V KK, Jayawardhana M, Martin AJ, et al. Association of bolus feeding with splanchnic and cerebral oxygen utilization efficiency among premature infants with anemia and after blood transfusion[J]. JAMA Netw Open, 2020, 3(2): e200149. PMID: 32108891. PMCID: PMC7049081. DOI: 10.1001/jamanetworkopen.2020.0149.
18 Schindler T, Yeo KT, Bolisetty S, et al. FEEding DURing red cell transfusion (FEEDUR RCT): a multi-arm randomised controlled trial[J]. BMC Pediatr, 2020, 20(1): 346. PMID: 32664953. PMCID: PMC7359615. DOI: 10.1186/s12887-020-02233-3.
19 Jasani B, Rao S, Patole S. Withholding feeds and transfusion-associated necrotizing enterocolitis in preterm infants: a systematic review[J]. Adv Nutr, 2017, 8(5): 764-769. PMID: 28916576. PMCID: PMC5593105. DOI: 10.3945/an.117.015818.
20 Hilditch C, Keir A. Do feeding practices during transfusion influence the risk of developing necrotising enterocolitis in preterm infants?[J]. J Paediatr Child Health, 2018, 54(5): 582-584. PMID: 29756373. DOI: 10.1111/jpc.13880.
21 王琦凡, 许白叶, 赖素贤, 等. 暂停肠道喂养对新生儿输血相关性坏死性小肠结肠炎的保护作用分析[J]. 中华新生儿科杂志(中英文), 2017, 32(3): 176-179. DOI: 10.3760/cma.j.issn.2096-2932.2017.03.004.
22 Rai SE, Sidhu AK, Krishnan RJ. Transfusion-associated necrotizing enterocolitis re-evaluated: a systematic review and meta-analysis[J]. J Perinat Med, 2018, 46(6): 665-676. PMID: 29068791. DOI: 10.1515/jpm-2017-0048.
23 Bajaj M, Lulic-Botica M, Hanson A, et al. Feeding during transfusion and the risk of necrotizing enterocolitis in preterm infants[J]. J Perinatol, 2019, 39(4): 540-546. PMID: 30723281. DOI: 10.1038/s41372-019-0328-7.
24 Gale C, Modi N, Jawad S, et al. The WHEAT pilot trial-WithHolding Enteral feeds Around packed red cell Transfusion to prevent necrotising enterocolitis in preterm neonates: a multicentre, electronic patient record (EPR), randomised controlled point-of-care pilot trial[J]. BMJ Open, 2019, 9(9): e033543. PMID: 31542771. PMCID: PMC6756449. DOI: 10.1136/bmjopen-2019-033543.
25 李淑涓, 曹云. 早产儿经母乳获得性巨细胞病毒感染的研究进展[J]. 中华围产医学杂志, 2014, 17(11): 773-777. DOI: 10.3760/cma.j.issn.1007-9408.2014.11.013.
26 Martins-Celini FP, Yamamoto AY, Passos DM, et al. Incidence, risk factors, and morbidity of acquired postnatal cytomegalovirus infection among preterm infants fed maternal milk in a highly seropositive population[J]. Clin Infect Dis, 2016, 63(7): 929-936. PMID: 27313267. DOI: 10.1093/cid/ciw394.
27 张文娟, 王皓, 陈明曦, 等. 母乳喂养对极早产儿获得性巨细胞病毒感染的影响[J]. 重庆医学, 2023, 52(9): 1287-1291. DOI: 10.3969/j.issn.1671-8348.2023.09.002.
28 Hosseini M, Esmaili HA, Abdoli Oskouei S, et al. Evaluation of the freeze-thawing method in reducing viral load of cytomegalovirus in breast milk of mothers of preterm infants[J]. Breastfeed Med, 2016, 11: 557-560. PMID: 27754707. DOI: 10.1089/bfm.2016.0107.
29 Balcells C, Botet F, Gayete S, et al. Vertically transmitted cytomegalovirus infection in newborn preterm infants[J]. J Perinat Med, 2016, 44(5): 485-490. PMID: 26845714. DOI: 10.1515/jpm-2015-0325.
30 游雪琴, 应倩, 羊芸, 等. 冷冻母乳喂养与胎龄<32周或出生体重<1 500 g早产儿巨细胞病毒感染的关系[J]. 中华围产医学杂志, 2021, 24(7): 518-524. DOI: 10.3760/cma.j.cn113903-20210310-00201.
31 Omarsdottir S, Casper C, Navér L, et al. Cytomegalovirus infection and neonatal outcome in extremely preterm infants after freezing of maternal milk[J]. Pediatr Infect Dis J, 2015, 34(5): 482-489. PMID: 25879648. DOI: 10.1097/INF.0000000000000619.
32 Yoo HS, Sung SI, Jung YJ, et al. Prevention of cytomegalovirus transmission via breast milk in extremely low birth weight infants[J]. Yonsei Med J, 2015, 56(4): 998-1006. PMID: 26069123. PMCID: PMC4479869. DOI: 10.3349/ymj.2015.56.4.998.
33 Section on Breastfeeding. Breastfeeding and the use of human milk[J]. Pediatrics, 2012, 129(3): e827-e841. PMID: 22371471. DOI: 10.1542/peds.2011-3552.
34 Picaud JC, Buffin R, Gremmo‐Feger G, et al. Review concludes that specific recommendations are needed to harmonise the provision of fresh mother's milk to their preterm infants[J]. Acta Paediatr, 2018, 107(7): 1145-1155. PMID: 29412475. PMCID: PMC6032854. DOI: 10.1111/apa.14259.
35 中国医师协会新生儿科医师分会, 中国医师协会新生儿科医师分会感染专业委员会, 中华新生儿科杂志编辑委员会. 新生儿巨细胞病毒感染管理专家共识[J]. 中华新生儿科杂志, 2021, 36(6): 1-7. DOI: 10.3760/cma.j.issn.2096-2932.2021.06.001.
36 Embleton ND, Jennifer Moltu S, Lapillonne A, et al. Enteral nutrition in preterm infants (2022): a position paper from the ESPGHAN Committee on Nutrition and invited experts[J]. J Pediatr Gastroenterol Nutr, 2023, 76(2): 248-268. PMID: 36705703. DOI: 10.1097/MPG.0000000000003642.
37 Havranek T, Madramootoo C, Carver JD. Nasal continuous positive airway pressure affects pre- and postprandial intestinal blood flow velocity in preterm infants[J]. J Perinatol, 2007, 27(11): 704-708. PMID: 17703183. DOI: 10.1038/sj.jp.7211808.
38 Jaile JC, Levin T, Wung JT, et al. Benign gaseous distension of the bowel in premature infants treated with nasal continuous airway pressure: a study of contributing factors[J]. AJR Am J Roentgenol, 1992, 158(1): 125-127. PMID: 1727337. DOI: 10.2214/ajr.158.1.1727337.
39 Lemyre B, Davis PG, De Paoli AG, et al. Nasal intermittent positive pressure ventilation (NIPPV) versus nasal continuous positive airway pressure (NCPAP) for preterm neonates after extubation[J]. Cochrane Database Syst Rev, 2014(9): CD003212. PMID: 25188554. DOI: 10.1002/14651858.CD003212.pub2.
40 Behnke J, Estreich V, Oehmke F, et al. Compatibility of rapid enteral feeding advances and noninvasive ventilation in preterm infants: an observational study[J]. Pediatr Pulmonol, 2022, 57(5): 1117-1126. PMID: 35191216. DOI: 10.1002/ppul.25868.
41 Behnke J, Estreich V, Oehmke F, et al. Noninvasive ventilation and rapid enteral feeding advances in preterm infants: 2-year follow-up of the STENA-cohort[J]. Nutrients, 2023, 15(5): 1292. PMID: 36904291. PMCID: PMC10005522. DOI: 10.3390/nu15051292.
42 Amendolia B, Fisher K, Wittmann-Price RA, et al. Feeding tolerance in preterm infants on noninvasive respiratory support[J]. J Perinat Neonatal Nurs, 2014, 28(4): 300-304. PMID: 25347108. DOI: 10.1097/JPN.0000000000000063.
43 Bozzetti V, De Angelis C, Tagliabue PE. Nutritional approach to preterm infants on noninvasive ventilation: an update[J]. Nutrition, 2017, 37: 14-17. PMID: 28359356. DOI: 10.1016/j.nut.2016.12.010.
44 Havranek T, Rahimi M, Hall H, et al. Feeding preterm neonates with patent ductus arteriosus (PDA): intestinal blood flow characteristics and clinical outcomes[J]. J Matern Fetal Neonatal Med, 2015, 28(5): 526-530. PMID: 24824108. DOI: 10.3109/14767058.2014.923395.
45 Martini S, Corvaglia L, Aceti A, et al. Effect of patent ductus arteriosus on splanchnic oxygenation at enteral feeding introduction in very preterm infants[J]. J Pediatr Gastroenterol Nutr, 2019, 69(4): 493-497. PMID: 31211764. DOI: 10.1097/MPG.0000000000002420.
46 Samuels N, van de Graaf RA, de Jonge RCJ, et al. Risk factors for necrotizing enterocolitis in neonates: a systematic review of prognostic studies[J]. BMC Pediatr, 2017, 17(1): 105. PMID: 28410573. PMCID: PMC5391569. DOI: 10.1186/s12887-017-0847-3.
47 Louis D, Torgalkar R, Shah J, et al. Enteral feeding during indomethacin treatment for patent ductus arteriosus: association with gastrointestinal outcomes[J]. J Perinatol, 2016, 36(7): 544-548. PMID: 26914015. DOI: 10.1038/jp.2016.11.
48 Yanowitz TD, Reese J, Gillam-Krakauer M, et al. Superior mesenteric artery blood flow velocities following medical treatment of a patent ductus arteriosus[J]. J Pediatr, 2014, 164(3): 661-663. PMID: 24321538. PMCID: PMC4077598. DOI: 10.1016/j.jpeds.2013.11.002.
49 Kaur S, Manerkar S, Mondkar J, et al. The dilemma of feeding during the treatment of patent ductus arteriosus with oral ibuprofen in preterm infants ≤30 weeks of gestation: a randomized controlled trial[J]. J Perinatol, 2023, 43(2): 203-208. PMID: 36604581. DOI: 10.1038/s41372-022-01597-x.
50 Lembo C, El-Khuffash A, Fusch C, et al. Nutrition of the preterm infant with persistent ductus arteriosus: existing evidence and practical implications[J]. Pediatr Res, 2023. Epub ahead of print. PMID: 37563451. DOI: 10.1038/s41390-023-02754-4.
51 Cordova J, Sriram S, Patton T, et al. Manifestations of cow's-milk protein intolerance in preterm infants[J]. J Pediatr Gastroenterol Nutr, 2016, 62(1): 140-144. PMID: 26252918. DOI: 10.1097/MPG.0000000000000933.
52 Koletzko S, Niggemann B, Arato A, et al. Diagnostic approach and management of cow's-milk protein allergy in infants and children: ESPGHAN GI Committee practical guidelines[J]. J Pediatr Gastroenterol Nutr, 2012, 55(2): 221-229. PMID: 22569527. DOI: 10.1097/MPG.0b013e31825c9482.
53 中华医学会儿科学分会儿童保健学组, 中华医学会围产医学分会, 中国营养学会妇幼营养分会, 等. 母乳喂养促进策略指南(2018版)[J]. 中华儿科杂志, 2018, 56(4): 261-266. PMID: 29614565. DOI: 10.3760/cma.j.issn.0578-1310.2018.04.005.
54 Vandenplas Y, Al-Hussaini B, Al-Mannaei K, et al. Prevention of allergic sensitization and treatment of cow's milk protein allergy in early life: the middle-east step-down consensus[J]. Nutrients, 2019, 11(7): 1444. PMID: 31248015. PMCID: PMC6683055. DOI: 10.3390/nu11071444.
55 Zamanillo-Campos R, Coto Alonso L, Fuentes Martín MJ, et al. Nutritional counseling for cow's milk protein allergy in infants from birth to 2 y of ages: scoping review[J]. Nutrition, 2022, 98: 111633. PMID: 35447465. DOI: 10.1016/j.nut.2022.111633.
56 姜雅楠, 邢燕. 早产儿牛奶蛋白过敏诊疗进展[J]. 中华预防医学杂志, 2021, 55(5): 583-591. PMID: 34034397. DOI: 10.3760/cma.j.cn112150-20210301-00204.
57 Heyman MB, Committee on Nutrition. Lactose intolerance in infants, children, and adolescents[J]. Pediatrics, 2006, 118(3): 1279-1286. PMID: 16951027. DOI: 10.1542/peds.2006-1721.
58 叶环, 饶燕晓, 徐琛, 等. 住院新生儿乳糖酶缺乏及其体格生长的随访研究[J]. 发育医学电子杂志, 2019, 7(2): 115-120. DOI: 10.3969/j.issn.2095-5340.2019.02.008.
59 Erasmus HD, Ludwig-Auser HM, Paterson PG, et al. Enhanced weight gain in preterm infants receiving lactase-treated feeds: a randomized, double-blind, controlled trial[J]. J Pediatr, 2002, 141(4): 532-537. PMID: 12378193. DOI: 10.1067/mpd.2002.127499.
60 王丽, 王依闻, 谭金童, 等. 乳糖酶添加剂对早产儿乳糖不耐受有效性和安全性的前瞻性随机对照研究[J]. 中国当代儿科杂志, 2021, 23(7): 671-676. PMID: 34266522. PMCID: PMC8292650. DOI: 10.7499/j.issn.1008-8830.2102038.
61 查新祎, 王依闻, 毛朋亮, 等. 乳糖酶添加剂对早产儿乳糖不耐受有效性及安全性: 一项前瞻性、多中心、随机对照研究[J]. 临床儿科杂志, 2023, 41(1): 34-41. DOI: 10.12372/jcp.2023.22e1095.
62 中国医师协会新生儿科医师分会循证专业委员会. 早产儿喂养不耐受临床诊疗指南(2020)[J]. 中国当代儿科杂志, 2020, 22(10): 1047-1055. PMID: 33059799. PMCID: PMC7568993. DOI: 10.7499/j.issn.1008-8830.2008132.
63 曹云, 李正红, 韩树萍, 等. 新生儿重症监护室母乳使用专家共识[J]. 中国循证儿科杂志, 2021, 16(3): 171-178. DOI: 10.3969/j.issn.1673-5501.2021.03.001.
64 Jadcherla SR, Slaughter JL, Stenger MR, et al. Practice variance, prevalence, and economic burden of premature infants diagnosed with GERD[J]. Hosp Pediatr, 2013, 3(4): 335-341. PMID: 24435191. PMCID: PMC4075760. DOI: 10.1542/hpeds.2013-0036.
65 van Wijk MP, Benninga MA, Dent J, et al. Effect of body position changes on postprandial gastroesophageal reflux and gastric emptying in the healthy premature neonate[J]. J Pediatr, 2007, 151(6): 585-590.e2. PMID: 18035135. DOI: 10.1016/j.jpeds.2007.06.015.
66 Corvaglia L, Rotatori R, Ferlini M, et al. The effect of body positioning on gastroesophageal reflux in premature infants: evaluation by combined impedance and pH monitoring[J]. J Pediatr, 2007, 151(6): 591-596.e1. PMID: 18035136. DOI: 10.1016/j.jpeds.2007.06.014.
67 Bhat RY, Rafferty GF, Hannam S, et al. Acid gastroesophageal reflux in convalescent preterm infants: effect of posture and relationship to apnea[J]. Pediatr Res, 2007, 62(5): 620-623. PMID: 17805196. DOI: 10.1203/PDR.0b013e3181568123.
68 van Wijk MP, Benninga MA, Davidson GP, et al. Small volumes of feed can trigger transient lower esophageal sphincter relaxation and gastroesophageal reflux in the right lateral position in infants[J]. J Pediatr, 2010, 156(5): 744-748.e1. PMID: 20097362. DOI: 10.1016/j.jpeds.2009.11.006.
69 Moon RY, Task Force on Sudden Infant Death Syndrome. SIDS and other sleep-related infant deaths: evidence base for 2016 updated recommendations for a safe infant sleeping environment[J]. Pediatrics, 2016, 138(5): e20162940. PMID: 27940805. DOI: 10.1542/peds.2016-2940.
70 Jadcherla SR, Chan CY, Moore R, et al. Impact of feeding strategies on the frequency and clearance of acid and nonacid gastroesophageal reflux events in dysphagic neonates[J]. JPEN J Parenter Enteral Nutr, 2012, 36(4): 449-455. PMID: 22038208. PMCID: PMC3800013. DOI: 10.1177/0148607111415980.
71 Malcolm WF, Smith PB, Mears S, et al. Transpyloric tube feeding in very low birthweight infants with suspected gastroesophageal reflux: impact on apnea and bradycardia[J]. J Perinatol, 2009, 29(5): 372-375. PMID: 19242488. PMCID: PMC2827248. DOI: 10.1038/jp.2008.234.
72 Watson J, McGuire W. Transpyloric versus gastric tube feeding for preterm infants[J]. Cochrane Database Syst Rev, 2013, 2013(2): CD003487. PMID: 23450542. PMCID: PMC7154386. DOI: 10.1002/14651858.CD003487.pub3.
73 Levy DS, Osborn E, Hasenstab KA, et al. The effect of additives for reflux or dysphagia management on osmolality in ready-to-feed preterm formula: practice implications[J]. JPEN J Parenter Enteral Nutr, 2019, 43(2): 290-297. PMID: 29992586. PMCID: PMC6328349. DOI: 10.1002/jpen.1418.
74 Abrams SA. Be cautious in using thickening agents for preemies[J]. AAP News, 2011, 32(7): 23. DOI: 10.1542/aapnews.2011327-23.
75 Corvaglia L, Mariani E, Aceti A, et al. Extensively hydrolyzed protein formula reduces acid gastro-esophageal reflux in symptomatic preterm infants[J]. Early Hum Dev, 2013, 89(7): 453-455. PMID: 23642476. DOI: 10.1016/j.earlhumdev.2013.04.003.
76 Logarajaha V, Onga C, Jayagobib PA, et al. PP-15 the effect of extensively hydrolyzed protein formula in preterm infants with symptomatic gastro-oesophageal reflux[J]. J Pediatr Gastroenterol Nutr, 2015, 61(4): 526. DOI: 10.1097/01.mpg.0000472243.59979.4a.
77 Sawyer C, Sanghavi R, Ortigoza EB. Neonatal gastroesophageal reflux[J]. Early Hum Dev, 2022, 171: 105600. PMID: 35716649. PMCID: PMC9983357. DOI: 10.1016/j.earlhumdev.2022.105600.
78 Rosen R, Vandenplas Y, Singendonk M, et al. Pediatric gastroesophageal reflux clinical practice guidelines: joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition[J]. J Pediatr Gastroenterol Nutr, 2018, 66(3): 516-554. PMID: 29470322. PMCID: PMC5958910. DOI: 10.1097/MPG.0000000000001889.
79 Elia S, Ciarcià M, Cini N, et al. Effect of fortification on the osmolality of human milk[J]. Ital J Pediatr, 2023, 49(1): 72. PMID: 37316866. PMCID: PMC10268382. DOI: 10.1186/s13052-023-01463-2.
80 苑静, 孙之星, 淡海涛, 等. 母乳渗透压影响因素及研究进展[J]. 中华新生儿科杂志(中英文), 2023, 38(4): 246-249. DOI: 10.3760/cma.j.issn.2096-2932.2023.04.014.
81 Chandran S, Chua MC, Lin W, et al. Medications that increase osmolality and compromise the safety of enteral feeding in preterm infants[J]. Neonatology, 2017, 111(4): 309-316. PMID: 28030867. DOI: 10.1159/000454667.
82 Shah DD, Kuzmov A, Clausen D, et al. Osmolality of commonly used oral medications in the neonatal intensive care unit[J]. J Pediatr Pharmacol Ther, 2021, 26(2): 172-178. PMID: 33603581. PMCID: PMC7887878. DOI: 10.5863/1551-6776-26.2.172.
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