基于Z值回归模型诊断儿童冠状动脉病变的研究

doi:10.7499/j.issn.1008-8830.2405030

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Abstract Objective To construct a Z-score regression model for coronary artery diameter based on echocardiographic data from children in Sichuan Province and to establish a Z-score calculation formula. Methods A total of 744 healthy children who underwent physical examinations at Sichuan Provincial People's Hospital from January 2020 to December 2022 were selected as the modeling group, while 251 children diagnosed with Kawasaki disease at the same hospital from January 2018 to December 2022 were selected as the validation group. Pearson correlation analysis was conducted to analyze the relationships between coronary artery diameter values and age, height, weight, and body surface area. A regression model was constructed using function transformation to identify the optimal regression model and establish the Z-score calculation formula, which was then validated. Results The Pearson correlation analysis showed that the correlation coefficients for the diameters of the left main coronary artery, left anterior descending artery, left circumflex artery, and right coronary artery with body surface area were 0.815, 0.793, 0.704, and 0.802, respectively (P<0.05). Among the constructed regression models, the power function regression model demonstrated the best performance and was therefore chosen as the optimal model for establishing the Z-score calculation formula. Based on this Z-score calculation formula, the detection rate of coronary artery lesions was found to be 21.5% (54/251), which was higher than the detection rate based on absolute values of coronary artery diameter. Notably, in the left anterior descending and left circumflex arteries, the detection rate of coronary artery lesions using this Z-score calculation formula was higher than that of previous classic Z-score calculation formulas. Conclusions The Z-score calculation formula established based on the power function regression model has a higher detection rate for coronary artery lesions, providing a strong reference for clinicians, particularly in assessing coronary artery lesions in children with Kawasaki disease.

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	WANG Yong
	JIANG Jia-Ying
	DENG Yan
	LI Bo
	SHUAI Ping
	HU Xiao-Ping
	ZHANG Yin-Yan
	WU Han
	YE Lu-Wei
	PENG Qian

Key words： Kawasaki disease Coronary artery lesion Coronary artery Z-score Echocardiography Child

Received: 10 May 2024

Corresponding Authors: Email： qian70910@263.net E-mail: qian70910@263.net

Cite this article:

WANG Yong,JIANG Jia-Ying,DENG Yan et al. Diagnosis of coronary artery lesions in children based on Z-score regression model[J]. CJCP, 2025, 27(2): 176-183.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2405030 OR http://www.zgddek.com/EN/Y2025/V27/I2/176

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