初乳口腔免疫疗法对极低出生体重儿临床结局影响的Meta分析

doi:10.7499/j.issn.1008-8830.2406104

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Abstract Objective To evaluate the effect of colostrum oral immune therapy (COIT) on clinical outcomes in very low birth weight (VLBW) infants. Methods A computer-based search was conducted in databases including China National Knowledge Infrastructure, Wanfang Data, Weipu Database, Chinese Biomedical Literature Service System, PubMed, Embase, Web of Science, the Cochrane Library, and CINAHL for randomized controlled trials regarding the application of COIT in VLBW infants published from the establishment of the database to February 2024. Meta analysis was performed using RevMan 5.3 software. Results A total of 14 randomized controlled trials were included, involving 1 386 VLBW infants, with 690 in the COIT group and 696 in the control group. The results showed that COIT significantly reduced the incidence of clinical late-onset sepsis (LOS) (RR=0.75, 95%CI: 0.64-0.88, P<0.001), the incidence of blood culture-proven LOS (RR=0.72, 95%CI: 0.57-0.92, P=0.008), mortality rate (RR=0.70, 95%CI: 0.52-0.95, P=0.020), the incidence of necrotizing enterocolitis (RR=0.65, 95%CI: 0.46-0.92, P=0.020), and the incidence of feeding intolerance (RR=0.49, 95%CI: 0.29-0.80, P=0.004). It also shortened the time to achieve full enteral nutrition (MD=-2.13, 95%CI: -4.03 to -0.23, P=0.030). Conclusions COIT can reduce the incidence rates of LOS, necrotizing enterocolitis, and feeding intolerance, as well as the mortality rate, while also shortening the time to achieve full enteral nutrition in VLBW infants.

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	LU Yan
	WANG Li-Li
	WANG Li
	ZHU Ke-Ran

Key words： Oral immune therapy Colostrum Meta analysis Very low birth weight infant

Received: 27 June 2024

Corresponding Authors: Email：wllwywz@163.com。 E-mail: wllwywz@163.com

Cite this article:

LU Yan,WANG Li-Li,WANG Li et al. Effect of colostrum oral immune therapy on the the clinical outcomes in very low birth weight infants: a Meta analysis[J]. CJCP, 2025, 27(2): 155-164.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2406104 OR http://www.zgddek.com/EN/Y2025/V27/I2/155

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