肝炎相关性再生障碍性贫血合并噬血细胞综合征1例并文献复习

doi:10.7499/j.issn.1008-8830.2409118

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Abstract A 4-year-old boy was admitted to the hospital with a 3-day history of rash and intermittent abdominal pain, during which abnormal results from routine blood tests were discovered. Initially, he presented with acute jaundice hepatitis and pancytopenia. The patient's condition progressed rapidly, with recurrent fever, worsening jaundice of the skin and sclera, and progressively worsening hepatosplenomegaly. Liver function impairment and bone marrow failure continued to deteriorate, while cytokine levels continued to rise. After excluding infections, autoimmune diseases, tumors, genetic metabolic disorders, and toxicities, the patient was diagnosed with hepatitis-associated aplastic anemia (HAAA) complicated by hemophagocytic lymphohistiocytosis (HLH). Following treatment with corticosteroids, plasma exchange, intravenous immunoglobulin, and liver protection therapy, the patient's symptoms partially alleviated. Aplastic anemia complicated by HLH is relatively uncommon, and HAAA complicated by HLH is even rarer, often presenting insidiously and severely. This paper presents a case of HAAA complicated by HLH and summarizes previously reported cases in the literature, providing references for the early diagnosis and treatment of this condition.

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	ZHOU Xin
	CHEN Xiao-Yu
	WEN Chuan
	LUO Sen-Lin

Key words： Hepatitis-associated aplastic anemia Hemophagocytic lymphohistiocytosis Child

Received: 23 September 2024

Cite this article:

ZHOU Xin,CHEN Xiao-Yu,WEN Chuan et al. A case of hepatitis-associated aplastic anemia complicated by hemophagocytic lymphohistiocytosis and literature review[J]. CJCP, 2025, 27(4): 465-471.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2409118 OR http://www.zgddek.com/EN/Y2025/V27/I4/465

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