Analysis of nutritional status before and after different induction therapies in children with Crohn's disease

Lei-Lei CHEN; Yu YU; You-You LUO; Jie CHEN

doi:10.7499/j.issn.1008-8830.2410125

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Chinese Journal of Contemporary Pediatrics ›› 2025, Vol. 27 ›› Issue (6) : 702-708. DOI: 10.7499/j.issn.1008-8830.2410125

CLINICAL RESEARCH

Analysis of nutritional status before and after different induction therapies in children with Crohn's disease

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Abstract

Objective To study the impact of different induction remission therapies on the nutritional status of children with Crohn's disease (CD). Methods A retrospective analysis was conducted on the medical data of 188 children with CD who received induction remission therapy at the Children's Hospital, Zhejiang University School of Medicine from January 2013 to May 2023. The effects of three induction remission therapies—exclusive enteral nutrition (EEN), corticosteroids, and infliximab (IFX)—on height, weight, hemoglobin, and trace elements were compared. Results After induction remission therapy, the weight-for-age Z scores and serum levels of hemoglobin and albumin in all three groups significantly increased (P<0.05), while the height-for-age Z scores showed no change (P>0.05). The levels of folic acid, 25-hydroxy vitamin D, serum iron, and total calcium increased, and serum copper levels decreased in the EEN and IFX groups (P<0.05). Vitamin B₁₂ levels improved in the EEN group (P<0.05). Conclusions EEN, corticosteroids, and IFX may effectively improve the weight-for-age Z scores and serum levels of hemoglobin and albumin in children with CD. EEN and IFX seem to be superior to corticosteroid therapy in improving 25-hydroxy vitamin D, folic acid, serum iron, and total calcium levels.

Key words

Crohn's disease / Nutrition / Induction remission / Child

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Lei-Lei CHEN , Yu YU , You-You LUO , et al. Analysis of nutritional status before and after different induction therapies in children with Crohn's disease[J]. Chinese Journal of Contemporary Pediatrics. 2025, 27(6): 702-708 https://doi.org/10.7499/j.issn.1008-8830.2410125

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