新生儿肠外营养管理专家共识（2025）

doi:10.7499/j.issn.1008-8830.2411156

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Abstract Parenteral nutrition (PN) is widely utilized in the field of neonatology and is a critical life-saving intervention for critically ill neonates or preterm infants who cannot meet their energy and nutrient needs through enteral feeding. To further standardize and optimize the clinical management of PN, this consensus was developed by a working group based on relevant research progress both domestically and internationally. Employing the Grading of Recommendations Assessment, Development and Evaluation, the consensus presents 24 recommendations covering seven aspects of PN: indications, administration routes, energy, fluid volume, composition of nutritional solutions, timing of cessation, and monitoring. The aim is to provide guidance for relevant practitioners in PN management to improve the short-term and long-term outcomes for neonates.

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	Nutritional Committee of Neonatology Branch of Chinese Medical Doctor Association
	Preterm Committee of Neonatology Branch of Chinese Medical Doctor Association
	Editorial Committee of Chinese Journal of Contemporary Pediatrics

Key words： Parenteral nutrition Nutrient Amino acid Lipid emulsion Expert consensus Preterm infant

Received: 27 November 2024

Corresponding Authors: Tong X-M, Email: tongxm2007@126.com E-mail: tongxm2007@126.com

Cite this article:

Nutritional Committee of Neonatology Branch of Chinese Medical Doctor Association,Preterm Committee of Neonatology Branch of Chinese Medical Doctor Association,Editorial Committee of Chinese Journal of Contemporary Pediatrics. Expert consensus on parenteral nutrition management in neonates (2025)[J]. CJCP, 2025, 27(3): 247-261.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2411156 OR http://www.zgddek.com/EN/Y2025/V27/I3/247

	沈蔚, 郑直, 林新祝, 等. 住院极早产儿宫外生长迟缓及相关因素的多中心前瞻性研究[J]. 中国当代儿科杂志, 2022, 24(2): 132-140. PMID: 35209977. PMCID: PMC8884052. DOI: 10.7499/j.issn.1008-8830.2111143.
	早产儿营养调查协作组. 新生儿重症监护病房中早产儿营养相关状况多中心调查974例报告[J]. 中华儿科杂志, 2009, 47(1): 12-17. PMID: 19573373. DOI: 10.3760/cma.j.issn.0578-1310.2009.01.003.
	Martínez-Jiménez MD, Gómez-García FJ, Gil-Campos M, et al. Comorbidities in childhood associated with extrauterine growth restriction in preterm infants: a scoping review[J]. Eur J Pediatr, 2020, 179(8): 1255-1265. PMID: 32096070. DOI: 10.1007/s00431-020-03613-8.
	Makker K, Ji Y, Hong X, et al. Antenatal and neonatal factors contributing to extra uterine growth failure (EUGR) among preterm infants in Boston birth cohort (BBC)[J]. J Perinatol, 2021, 41(5): 1025-1032. PMID: 33589730. PMCID: PMC7883994. DOI: 10.1038/s41372-021-00948-4.
	Baillat M, Pauly V, Dagau G, et al. Association of first-week nutrient intake and extrauterine growth restriction in moderately preterm infants: a regional population-based study[J]. Nutrients, 2021, 13(1): 227. PMID: 33466801. PMCID: PMC7830065. DOI: 10.3390/nu13010227.
	Schneider J, Fischer Fumeaux CJ, Duerden EG, et al. Nutrient intake in the first two weeks of life and brain growth in preterm neonates[J]. Pediatrics, 2018, 141(3): e20172169. PMID: 29440285. DOI: 10.1542/peds.2017-2169.
	7 中华医学会肠外肠内营养学分会儿科学组, 中华医学会儿科学分会新生儿学组, 中华医学会小儿外科学分会新生儿外科学组, 等. 中国新生儿营养支持临床应用指南[J]. 中华小儿外科杂志, 2013, 34(10): 782-787. DOI: 10.3760/cma.j.issn.0253-3006.2013.10.016.
	Robinson DT, Calkins KL, Chen Y, et al. Guidelines for parenteral nutrition in preterm infants: The American Society for Parenteral and Enteral Nutrition[J]. JPEN J Parenter Enteral Nutr, 2023, 47(7): 830-858. PMID: 37610837. DOI: 10.1002/jpen.2550.
	Mihatsch W, Shamir R, van Goudoever JB, et al. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: guideline development process for the updated guidelines[J]. Clin Nutr, 2018, 37(6 Pt B): 2306-2308. PMID: 30055868. DOI: 10.1016/j.clnu.2018.06.943.
	10 NICE. Neonatal parenteral nutrition[EB/OL]. [2021-12-07]. https://www.nice.org.uk/guidance/NG154.
	Groh-Wargo S, Barr SM. Parenteral nutrition[J]. Clin Perinatol, 2022, 49(2): 355-379. PMID: 35659091. DOI: 10.1016/j.clp.2022.02.002.
	12 Schünemann H, Bro?ek J, Guyatt G, et al. GRADE Handbook[EB/OL]. (2013-10)[2020-07-16]. https://gdt.gradepro.org/app/handbook/handbook.html.
	13 GRADEpro GDT. GRADE your evidence and improve your guideline development in health care[EB/OL]. [2020-07-10]. https://www.gradepro.org/.
	14 BalshemH, HelfandaM, SchunemannHJ, 等. GRADE指南: Ⅲ.证据质量分级[J]. 中国循证医学杂志, 2011, 11(4): 451-455. DOI: 10.3969/j.issn.1672-2531.2011.04.017.
	Bolisetty S, Osborn D, Schindler T, et al. Standardised neonatal parenteral nutrition formulations: Australasian neonatal parenteral nutrition consensus update 2017[J]. BMC Pediatr, 2020, 20(1): 59. PMID: 32035481. PMCID: PMC7007668. DOI: 10.1186/s12887-020-1958-9.
	Leenders EKSM, de Waard M, van Goudoever JB. Low- versus high-dose and early versus late parenteral amino-acid administration in very-low-birth-weight infants: a systematic review and meta-analysis[J]. Neonatology, 2018, 113(3): 187-205. PMID: 29268262. DOI: 10.1159/000481192.
	van Goudoever JB, Carnielli V, Darmaun D, et al. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: amino acids[J]. Clin Nutr, 2018, 37(6 Pt B): 2315-2323. PMID: 30100107. DOI: 10.1016/j.clnu.2018.06.945.
	Prusakov P, Speaks S, Magers JS. Parenteral nutrition in moderately preterm, otherwise healthy neonates is not associated with improved short-term growth outcomes[J]. JPEN J Parenter Enteral Nutr, 2020, 44(8): 1519-1524. PMID: 32026496. DOI: 10.1002/jpen.1785.
	Biagetti C, Correani A, Antognoli L, et al. Which birth weight threshold to start parenteral nutrition? A single center experience[J]. Eur J Clin Nutr, 2023, 77(4): 474-480. PMID: 36627415. DOI: 10.1038/s41430-022-01257-5.
	20 李正红, 王丹华, 童笑梅, 等. 晚期早产儿营养管理专家共识[J]. 中国循证儿科杂志, 2022, 17(6): 405-413. DOI: 10.3969/j.issn.1673-5501.2022.06.001.
	21 邱文娟, 杜陶子, 夏瑜. 儿童遗传代谢病急性期的营养管理[J]. 临床儿科杂志, 2023, 41(6): 401-405. DOI: 10.12372/jcp.2023.23e0366.
	Lapillonne A, Kermorvant-Duchemin E. A systematic review of practice surveys on parenteral nutrition for preterm infants[J]. J Nutr, 2013, 143(12 Suppl): 2061S-2065S. PMID: 24108136. DOI: 10.3945/jn.113.176982.
	Ainsworth S, McGuire W. Percutaneous central venous catheters versus peripheral cannulae for delivery of parenteral nutrition in neonates[J]. Cochrane Database Syst Rev, 2015, 2015(10): CD004219. PMID: 26439610. PMCID: PMC9250057. DOI: 10.1002/14651858.CD004219.pub4.
	Boullata JI, Gilbert K, Sacks G, et al. A.S.P.E.N. clinical guidelines: parenteral nutrition ordering, order review, compounding, labeling, and dispensing[J]. JPEN J Parenter Enteral Nutr, 2014, 38(3): 334-377. PMID: 24531708. DOI: 10.1177/0148607114521833.
	Pezzati M, Filippi L, Chiti G, et al. Central venous catheters and cardiac tamponade in preterm infants[J]. Intensive Care Med, 2004, 30(12): 2253-2256. PMID: 15517163. DOI: 10.1007/s00134-004-2472-5.
	Ainsworth SB, Clerihew L, McGuire W. Percutaneous central venous catheters versus peripheral cannulae for delivery of parenteral nutrition in neonates[J]. Cochrane Database Syst Rev, 2007(3): CD004219. PMID: 17636749. DOI: 10.1002/14651858.CD004219.pub3.
	中国医师协会新生儿科医师分会循证专业委员会. 新生儿经外周置入中心静脉导管操作及管理指南（2021）[J]. 中国当代儿科杂志, 2021, 23(3): 201-212. PMID: 33691911. PMCID: PMC7969181. DOI: 10.7499/j.issn.1008-8830.2101087.
	Bethune K, Allwood M, Grainger C, et al. Use of filters during the preparation and administration of parenteral nutrition: position paper and guidelines prepared by a British pharmaceutical nutrition group working party[J]. Nutrition, 2001, 17(5): 403-408. PMID: 11377134. DOI: 10.1016/s0899-9007(01)00536-6.
	Dugan S, Le J, Jew RK. Maximum tolerated osmolarity for peripheral administration of parenteral nutrition in pediatric patients[J]. JPEN J Parenter Enteral Nutr, 2014, 38(7): 847-851. PMID: 23851423. DOI: 10.1177/0148607113495569.
	Hanifah S, Maulidani Y, Nugroho BH, et al. Provision of standardized all-in-one parenteral nutrition (AIO-PN) for very preterm neonates: evaluation at room and cold temperatures[J]. J Pharm Bioallied Sci, 2021, 13(1): 26-30. PMID: 34084045. PMCID: PMC8142921. DOI: 10.4103/jpbs.JPBS_278_19.
	Blackmer AB, Partipilo ML. Three-in-one parenteral nutrition in neonates and pediatric patients: risks and benefits[J]. Nutr Clin Pract, 2015, 30(3): 337-343. PMID: 25857309. DOI: 10.1177/0884533615580596.
	MacKay M, Jackson D, Eggert L, et al. Practice-based validation of calcium and phosphorus solubility limits for pediatric parenteral nutrition solutions[J]. Nutr Clin Pract, 2011, 26(6): 708-713. PMID: 22205559. DOI: 10.1177/0884533611426435.
	Nehra D, Carlson SJ, Fallon EM, et al. A.S.P.E.N. clinical guidelines: nutrition support of neonatal patients at risk for metabolic bone disease[J]. JPEN J Parenter Enteral Nutr, 2013, 37(5): 570-598. PMID: 23685349. DOI: 10.1177/0148607113487216.
	Koletzko B, Wieczorek S, Domell?f M, et al. Defining nutritional needs of preterm infants[J]. World Rev Nutr Diet, 2021, 122: 5-11. PMID: 34352755. DOI: 10.1159/000514739.
	Hay WW, Brown LD, Denne SC. Energy requirements, protein-energy metabolism and balance, and carbohydrates in preterm infants[J]. World Rev Nutr Diet, 2014, 110: 64-81. PMID: 24751622. DOI: 10.1159/000358459.
	Weintraub V, Mimouni FB, Dollberg S. Effect of birth weight and postnatal age upon resting energy expenditure in preterm infants[J]. Am J Perinatol, 2009, 26(3): 173-177. PMID: 19021091. DOI: 10.1055/s-0028-1103023.
	Bechard LJ, Parrott JS, Mehta NM. Systematic review of the influence of energy and protein intake on protein balance in critically ill children[J]. J Pediatr, 2012, 161(2): 333-339.e1. PMID: 22402566. DOI: 10.1016/j.jpeds.2012.01.046.
	Embleton ND, van den Akker CHP. Protein intakes to optimize outcomes for preterm infants[J]. Semin Perinatol, 2019, 43(7): 151154. PMID: 31303253. DOI: 10.1053/j.semperi.2019.06.002.
	39 van den Akker CHP, Saenz de Pipaon M, van Goudoever JB. Proteins and amino acids[M]//Koletzko B, Cheah FC, Domell?f M, et al. Nutritional Care of Preterm Infants: Scientific Basis and Practical Guidelines. Basel: Karger International, 2021.
	40 古谷纯朗. Manual of Neonatal Intensive Care Unit[M]. 5版. 东京: 金原出版株式会社, 2014: 177-180.
	Jochum F, Moltu SJ, Senterre T, et al. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: fluid and electrolytes[J]. Clin Nutr, 2018, 37(6 Pt B): 2344-2353. PMID: 30064846. DOI: 10.1016/j.clnu.2018.06.948.
	42 Koletzko B, Cheah FC, Domell?f M, et al. Nutritional care of preterm infants: scientific basis and practical guidelines[M]//World Review of Nutrition and Dietetics. Basel: Karger International, 2021: 103-121.
	Mesotten D, Joosten K, van Kempen A, et al. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: carbohydrates[J]. Clin Nutr, 2018, 37(6 Pt B): 2337-2343. PMID: 30037708. DOI: 10.1016/j.clnu.2018.06.947.
	Arsenault D, Brenn M, Kim S, et al. A.S.P.E.N. clinical guidelines: hyperglycemia and hypoglycemia in the neonate receiving parenteral nutrition[J]. JPEN J Parenter Enteral Nutr, 2012, 36(1): 81-95. PMID: 22179520. DOI: 10.1177/0148607111418980.
	Alsweiler JM, Harding JE, Bloomfield FH. Tight glycemic control with insulin in hyperglycemic preterm babies: a randomized controlled trial[J]. Pediatrics, 2012, 129(4): 639-647. PMID: 22430450. DOI: 10.1542/peds.2011-2470.
	Darmaun D, Lapillonne A, Simeoni U, et al. Parenteral nutrition for preterm infants: issues and strategy[J]. Arch Pediatr, 2018, 25(4): 286-294. PMID: 29656825. DOI: 10.1016/j.arcped.2018.02.005.
	Denne SC, Poindexter BB. Evidence supporting early nutritional support with parenteral amino acid infusion[J]. Semin Perinatol, 2007, 31(2): 56-60. PMID: 17462489. DOI: 10.1053/j.semperi.2007.02.005.
	Trivedi A, Jatana V, Sinn JK. Early versus late administration of amino acids in preterm infants receiving parenteral nutrition[J]. Cochrane Database Syst Rev, 2024, 1(1): CD008771. PMID: 38275196. PMCID: PMC10811752. DOI: 10.1002/14651858.CD008771.pub3.
	van Puffelen E, Vanhorebeek I, Joosten KFM, et al. Early versus late parenteral nutrition in critically ill, term neonates: a preplanned secondary subgroup analysis of the PEPaNIC multicentre, randomised controlled trial[J]. Lancet Child Adolesc Health, 2018, 2(7): 505-515. PMID: 30169323. DOI: 10.1016/S2352-4642(18)30131-7.
	Poindexter BB, Langer JC, Dusick AM, et al. Early provision of parenteral amino acids in extremely low birth weight infants: relation to growth and neurodevelopmental outcome[J]. J Pediatr, 2006, 148(3): 300-305. PMID: 16615955. DOI: 10.1016/j.jpeds.2005.10.038.
	Uthaya S, Liu X, Babalis D, et al. Nutritional evaluation and optimisation in neonates: a randomized, double-blind controlled trial of amino acid regimen and intravenous lipid composition in preterm parenteral nutrition[J]. Am J Clin Nutr, 2016, 103(6): 1443-1452. PMID: 27099248. PMCID: PMC4880995. DOI: 10.3945/ajcn.115.125138.
	Str?mmen K, Haag A, Moltu SJ, et al. Enhanced nutrient supply to very low birth weight infants is associated with higher blood amino acid concentrations and improved growth[J]. Clin Nutr ESPEN, 2017, 18: 16-22. PMID: 29132733. DOI: 10.1016/j.clnesp.2017.01.003.
	Bloomfield FH, Jiang Y, Harding JE, et al. Early amino acids in extremely preterm infants and neurodisability at 2 years[J]. N Engl J Med, 2022, 387(18): 1661-1672. PMID: 36322845. DOI: 10.1056/NEJMoa2204886.
	Martin CR. Parenteral protein in extremely preterm infants: more is not better[J]. N Engl J Med, 2022, 387(18): 1712-1713. PMID: 36322851. DOI: 10.1056/NEJMe2212522.
	Blanco C, McGill-Vargas L, Li C, et al. High branched-chain amino acid concentrations are found in preterm baboons receiving intravenous amino acid solutions and mimic alterations found in preterm infants[J]. JPEN J Parenter Enteral Nutr, 2019, 43(8): 1053-1064. PMID: 30729556. PMCID: PMC7241650. DOI: 10.1002/jpen.1507.
	Kirchberg FF, Harder U, Weber M, et al. Dietary protein intake affects amino acid and acylcarnitine metabolism in infants aged 6 months[J]. J Clin Endocrinol Metab, 2015, 100(1): 149-158. PMID: 25368978. DOI: 10.1210/jc.2014-3157.
	57 Pereira da Silva L, Pissarra S, Alexandrino AM, et al. Guidelines for neonatal parenteral nutrition: 2019 update by the Portuguese Neonatal Society. Part I. General aspects, energy, and macronutrients[J]. Port J Pediatr, 2019, 50(3): 209-219. DOI: 10.25754/pjp.2019.15981.
	杨庆, 林新祝. 长链多不饱和脂肪酸对新生儿的影响研究进展[J]. 中国当代儿科杂志, 2021, 23(7): 755-760. PMID: 34266537. PMCID: PMC8292656. DOI: 10.7499/j.issn.1008-8830.2104087.
	Lapillonne A, Fidler Mis N, Goulet O, et al. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: lipids[J]. Clin Nutr, 2018, 37(6 Pt B): 2324-2336. PMID: 30143306. DOI: 10.1016/j.clnu.2018.06.946.
	Kim K, Kim NJ, Kim SY. Safety and efficacy of early high parenteral lipid supplementation in preterm infants: a systematic review and meta-analysis[J]. Nutrients, 2021, 13(5): 1535. PMID: 34063216. PMCID: PMC8147506. DOI: 10.3390/nu13051535.
	Giretti I, D'Ascenzo R, Correani A, et al. Hypertriglyceridemia and lipid tolerance in preterm infants with a birth weight of less than 1250 g on routine parenteral nutrition[J]. Clin Nutr, 2021, 40(6): 4444-4448. PMID: 33526286. DOI: 10.1016/j.clnu.2020.12.039.
	Chan AP, Rostas S, Rogers S, et al. Parenteral nutrition in the neonatal intensive care unit: intravenous lipid emulsions[J]. Clin Perinatol, 2023, 50(3): 575-589. PMID: 37536765. DOI: 10.1016/j.clp.2023.04.012.
	McClave SA, Taylor BE, Martindale RG, et al. Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.)[J]. JPEN J Parenter Enteral Nutr, 2016, 40(2): 159-211. PMID: 26773077. DOI: 10.1177/0148607115621863.
	Yang Q, Kong J, Bai RM, et al. Effects of mixed oil emulsion on short-term clinical outcomes in premature infants: a prospective, multicenter, randomized controlled trial[J]. Eur J Clin Nutr, 2023, 77(8): 823-832. PMID: 37138099. PMCID: PMC10393776. DOI: 10.1038/s41430-023-01288-6.
	Wang YS, Shen W, Yang Q, et al. Analysis of risk factors for parenteral nutrition-associated cholestasis in preterm infants: a multicenter observational study[J]. BMC Pediatr, 2023, 23(1): 250. PMID: 37210514. PMCID: PMC10199576. DOI: 10.1186/s12887-023-04068-0.
	林榕, 杨庆, 王雅森, 等. 两种脂肪乳剂不同肠外营养时间对早产儿临床结局影响的比较: 一项随机对照多中心研究[J]. 中国当代儿科杂志, 2023, 25(9): 901-908. PMID: 37718394. PMCID: PMC10511226. DOI: 10.7499/j.issn.1008-8830.2303074.
	Zhang ZX, Yang Q, Shen W, et al. Effect of SMOF lipid emulsion on physical growth and extrauterine growth retardation in very preterm infants: insights from a multicenter retrospective cohort study[J]. Nutrition, 2023, 116: 112221. PMID: 37832169. DOI: 10.1016/j.nut.2023.112221.
	Asfour SS, Alshaikh B, AlMahmoud L, et al. SMOFlipid impact on growth and neonatal morbidities in very preterm infants[J]. Nutrients, 2022, 14(19): 3952. PMID: 36235604. PMCID: PMC9573282. DOI: 10.3390/nu14193952.
	Zou TT, Li JR, Zhu Y, et al. Fish oil-containing lipid emulsions prevention on parenteral nutrition-associated cholestasis in very low birth weight infants: a meta-analysis[J]. World J Pediatr, 2022, 18(7): 463-471. PMID: 35325398. PMCID: PMC9205820. DOI: 10.1007/s12519-022-00536-2.
	Robinson DT, Ayers P, Fleming B, et al. Recommendations for photoprotection of parenteral nutrition for premature infants: an ASPEN position paper[J]. Nutr Clin Pract, 2021, 36(5): 927-941. PMID: 34472142. DOI: 10.1002/ncp.10747.
	Chessex P, Laborie S, Nasef N, et al. Shielding parenteral nutrition from light improves survival rate in premature infants[J]. JPEN J Parenter Enteral Nutr, 2017, 41(3): 378-383. PMID: 26376662. DOI: 10.1177/0148607115606407.
	Mihatsch W, Fewtrell M, Goulet O, et al. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: calcium, phosphorus and magnesium[J]. Clin Nutr, 2018, 37(6 Pt B): 2360-2365. PMID: 30097365. DOI: 10.1016/j.clnu.2018.06.950.
	Vanek VW, Borum P, Buchman A, et al. A.S.P.E.N. position paper: recommendations for changes in commercially available parenteral multivitamin and multi-trace element products[J]. Nutr Clin Pract, 2012, 27(4): 440-491. PMID: 22730042. DOI: 10.1177/0884533612446706.
	Domell?f M, Szitanyi P, Simchowitz V, et al. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: iron and trace minerals[J]. Clin Nutr, 2018, 37(6 Pt B): 2354-2359. PMID: 30078716. DOI: 10.1016/j.clnu.2018.06.949.
	Bronsky J, Campoy C, Braegger C, et al. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: vitamins[J]. Clin Nutr, 2018, 37(6 Pt B): 2366-2378. PMID: 30100105. DOI: 10.1016/j.clnu.2018.06.951.
	Manninen S, Silvennoinen S, Bendel P, et al. Carnitine intake and serum levels associate positively with postnatal growth and brain size at term in very preterm infants[J]. Nutrients, 2022, 14(22): 4725. PMID: 36432412. PMCID: PMC9696952. DOI: 10.3390/nu14224725.
	Sasenick J, Miller M, Rastogi D, et al. Carnitine supplementation increases serum concentrations of free carnitine and total acylcarnitine in preterm neonates: a retrospective cohort study[J]. JPEN J Parenter Enteral Nutr, 2023, 47(6): 746-753. PMID: 37345267. DOI: 10.1002/jpen.2535.
	Salguero Olid A, Blanco Sánchez G, Alonso Ojembarrena A. A systematic review about prophylactic L-carnitine administration in parenteral nutrition of extremely preterm infants[J]. Farm Hosp, 2018, 42(4): 168-173. PMID: 29959842. DOI: 10.7399/fh.10976.
	Kola?ek S, Puntis JWL, Hojsak I, et al. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: venous access[J]. Clin Nutr, 2018, 37(6 Pt B): 2379-2391. PMID: 30055869. DOI: 10.1016/j.clnu.2018.06.952.
	Perrem L, Semberova J, O'Sullivan A, et al. Effect of early parenteral nutrition discontinuation on time to regain birth weight in very low birth weight infants: a randomized controlled trial[J]. JPEN J Parenter Enteral Nutr, 2019, 43(7): 883-890. PMID: 30613992. DOI: 10.1002/jpen.1502.
	Immeli L, Sankilampi U, M?kel? PM, et al. Length of nutritional transition associates negatively with postnatal growth in very low birthweight infants[J]. Nutrients, 2021, 13(11): 3961. PMID: 34836216. PMCID: PMC8622897. DOI: 10.3390/nu13113961.
	张蓉, 林新祝, 常艳美, 等. 早产儿支气管肺发育不良营养管理专家共识[J]. 中国当代儿科杂志, 2020, 22(8): 805-814. PMID: 32800025. PMCID: PMC7441505. DOI: 10.7499/j.issn.1008-8830.2005080.
	83 胡玉莲, 胡长霞. 早产儿肠外营养相关性肝病的诊断与治疗[J]. 中华实用儿科临床杂志, 2018, 33(19): 1454-1459. DOI: 10.3760/cma.j.issn.2095-428X.2018.19.004.
	Zamir I, Tornevi A, Abrahamsson T, et al. Hyperglycemia in extremely preterm infants: insulin treatment, mortality and nutrient intakes[J]. J Pediatr, 2018, 200: 104-110.e1. PMID: 29731360. DOI: 10.1016/j.jpeds.2018.03.049.
	Sinclair R, Schindler T, Lui K, et al. Hypertriglyceridaemia in extremely preterm infants receiving parenteral lipid emulsions[J]. BMC Pediatr, 2018, 18(1): 348. PMID: 30404604. PMCID: PMC6220513. DOI: 10.1186/s12887-018-1325-2.
	86 茹喜芳, 冯琪, 王颖, 等. 肠外营养中氨基酸用量对早产儿电解质的影响[J]. 中华新生儿科杂志, 2021, 36(3): 1-7. DOI: 10.3760/cma.j.issn.2096-2932.2021.03.001.
	Romańska J, Wawrzoniak T, Krajewski P, et al. Effects of early versus standard central line removal on the growth of preterm infants with very low birth weight: a non-inferiority, randomized clinical trial[J]. Nutrients, 2022, 14(22): 4766. PMID: 36432453. PMCID: PMC9692930. DOI: 10.3390/nu14224766.
	88 王薇, 侯朝铭, 高静, 等. 早产儿肠外营养相关并发症预防的最佳证据总结[J]. 军事护理, 2023, 40(5): 41-44. DOI: 10.3969/j.issn.2097-1826.2023.05.010.
	Izquierdo Renau M, Aldecoa-Bilbao V, Balcells Esponera C, et al. Applying methods for postnatal growth assessment in the clinical setting: evaluation in a longitudinal cohort of very preterm infants[J]. Nutrients, 2019, 11(11): 2772. PMID: 31739632. PMCID: PMC6893690. DOI: 10.3390/nu11112772.
	90 Motta M, Aversa S, Francesco M, et al. Extrauterine growth restriction in preterm very low birth weight infants: the use of a web-based system designed for computerized prescribing of parenteral nutrition in neonatal intensive care[J]. Newborn, 2023, 2(1): 1-10. DOI: 10.5005/jp-journals-11002-0052.
	González-García L, García-López E, Fernández-Colomer B, et al. Extrauterine growth restriction in very low birth weight infants: concordance between Fenton 2013 and INTERGROWTH-21st growth charts[J]. Front Pediatr, 2021, 9: 690788. PMID: 34235126. PMCID: PMC8255477. DOI: 10.3389/fped.2021.690788.
	92 中华人民共和国国家卫生健康委员会. 不同胎龄新生儿出生时生长评价标准: WS/T 800-2022[S]. 北京: 中国标准出版社, 2022.
	Tremblay G, Boudreau C, Bélanger S, et al. Body composition in very preterm infants: role of neonatal characteristics and nutrition in achieving growth similar to term infants[J]. Neonatology, 2017, 111(3): 214-221. PMID: 27866210. DOI: 10.1159/000450882.
	Nagel EM, Super J, Marka NA, et al. Body composition after implementation of an enhanced parenteral nutrition protocol in the neonatal intensive care unit: a randomised pilot trial[J]. Ann Hum Biol, 2024, 51(1): 2306352. PMID: 38293997. PMCID: PMC10964316. DOI: 10.1080/03014460.2024.2306352.