[1]	钱嘉航, 任军, 贾凌云, 等. 自身免疫性疾病与自身抗体概述[J]. 中国免疫学杂志, 2022, 38(17): 2152-2158. DOI: 10.3969/j.issn.1000-484X.2022.17.021 . Cited in this article [1]

[2]	中华医学会儿科学分会风湿病学组, 中国医师协会风湿免疫科医师分会儿科学组, 海峡两岸医药卫生交流协会风湿免疫病学专业委员会儿童学组, 等. 儿童自身炎症性疾病诊断与治疗专家共识[J]. 中华实用儿科临床杂志, 2022, 37(3): 161-172. DOI: 10.3760/cma.j.cn101070-20211109-01333 . Cited in this article [2]

[3]

Hu Y, Chen B, Yang F, et al. Emerging role of the cGAS-STING signaling pathway in autoimmune diseases: biologic function, mechanisms and clinical prospection[J]. Autoimmun Rev, 2022, 21(9): 103155. DOI: 10.1016/j.autrev.2022.103155 . https://www.ncbi.nlm.nih.gov/pubmed/35902046 Cited in this article [1]

[4]	Zheng W, Chen N, Meurens F, et al. How does cGAS avoid sensing self-DNA under normal physiological conditions?[J]. Int J Mol Sci, 2023, 24(19): 14738. PMCID: PMC10572901. DOI: 10.3390/ijms241914738 . https://www.ncbi.nlm.nih.gov/pubmed/37834184 Cited in this article [1]

[5]

Cheng F, Su T, Liu Y, et al. Targeting lymph nodes for systemic immunosuppression using cell-free-DNA-scavenging and cGAS-inhibiting nanomedicine-in-hydrogel for rheumatoid arthritis immunotherapy[J]. Adv Sci (Weinh), 2023, 10(26): e2302575. PMCID: PMC10502670. DOI: 10.1002/advs.202302575 . https://www.ncbi.nlm.nih.gov/pubmed/37435620 Cited in this article [1]

[6]	Wischnewski M, Ablasser A. Interplay of cGAS with chromatin[J]. Trends Biochem Sci, 2021, 46(10): 822-831. DOI: 10.1016/j.tibs.2021.05.011 . https://www.ncbi.nlm.nih.gov/pubmed/34215510 Cited in this article [1]

[7]	Talbot EJ, Joshi L, Thornton P, et al. cGAS-STING signalling regulates microglial chemotaxis in genome instability[J]. Nucleic Acids Res, 2024, 52(3): 1188-1206. PMCID: PMC10853792. DOI: 10.1093/nar/gkad1184 . https://www.ncbi.nlm.nih.gov/pubmed/38084916 Cited in this article [1]

[8]	Gao D, Li T, Li XD, et al. Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases[J]. Proc Natl Acad Sci U S A, 2015, 112(42): E5699-E5705. PMCID: PMC4620884. DOI: 10.1073/pnas.1516465112 . https://www.ncbi.nlm.nih.gov/pubmed/26371324 Cited in this article [2]

[9]	Bai J, Liu F. Nuclear cGAS: sequestration and beyond[J]. Protein Cell, 2022, 13(2): 90-101. PMCID: PMC8783940. DOI: 10.1007/s13238-021-00869-0 . https://www.ncbi.nlm.nih.gov/pubmed/34374004 Cited in this article [1]

[10]

Xie W, Lama L, Adura C, et al. Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation[J]. Proc Natl Acad Sci U S A, 2019, 116(24): 11946-11955. PMCID: PMC6575157 . DOI: 10.1073/pnas.1905013116 . https://www.ncbi.nlm.nih.gov/pubmed/31142647 Cited in this article [1]

[11]	Dvorkin S, Cambier S, Volkman HE, et al. New frontiers in the cGAS-STING intracellular DNA-sensing pathway[J]. Immunity, 2024, 57(4): 718-730. PMCID: PMC11013568. DOI: 10.1016/j.immuni.2024.02.019 . https://www.ncbi.nlm.nih.gov/pubmed/38599167 Cited in this article [1]

[12]	Ritchie C, Carozza JA, Li L. Biochemistry, cell biology, and pathophysiology of the innate immune cGAS-cGAMP-STING pathway[J]. Annu Rev Biochem, 2022, 91: 599-628. DOI: 10.1146/annurev-biochem-040320-101629 . https://www.ncbi.nlm.nih.gov/pubmed/35287475 Cited in this article [1]

[13]	Liu H, Wang F, Cao Y, et al. The multifaceted functions of cGAS[J]. J Mol Cell Biol, 2022, 14(5): mjac031. PMCID: PMC9475664. DOI: 10.1093/jmcb/mjac031 . https://www.ncbi.nlm.nih.gov/pubmed/35536585 Cited in this article [1]

[14]	Shinde O, Li P. The molecular mechanism of dsDNA sensing through the cGAS-STING pathway[J]. Adv Immunol, 2024, 162: 1-21. DOI: 10.1016/bs.ai.2024.02.003 . https://www.ncbi.nlm.nih.gov/pubmed/38866436 Cited in this article [1]

[15]

Hooy RM, Massaccesi G, Rousseau KE, et al. Allosteric coupling between Mn2+ and dsDNA controls the catalytic efficiency and fidelity of cGAS[J]. Nucleic Acids Res, 2020, 48(8): 4435-4447. PMCID: PMC7192592. DOI: 10.1093/nar/gkaa084 . https://www.ncbi.nlm.nih.gov/pubmed/32170294 Cited in this article [1]

[16]	Zhang X, Bai XC, Chen ZJ. Structures and mechanisms in the cGAS-STING innate immunity pathway[J]. Immunity, 2020, 53(1): 43-53. DOI: 10.1016/j.immuni.2020.05.013 . https://www.ncbi.nlm.nih.gov/pubmed/32668227 Cited in this article [1]

[17]	Liu Y, Lu X, Qin N, et al. STING, a promising target for small molecular immune modulator: a review[J]. Eur J Med Chem, 2021, 211: 113113. DOI: 10.1016/j.ejmech.2020.113113 . https://www.ncbi.nlm.nih.gov/pubmed/33360799 Cited in this article [1]

[18]	Shang G, Zhang C, Chen ZJ, et al. Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP[J]. Nature, 2019, 567(7748): 389-393. PMCID: PMC6859894. DOI: 10.1038/s41586-019-0998-5 . https://www.ncbi.nlm.nih.gov/pubmed/30842659 Cited in this article [1]

[19]	Reisländer T, Groelly FJ, Tarsounas M. DNA damage and cancer immunotherapy: a STING in the tale[J]. Mol Cell, 2020, 80(1): 21-28. DOI: 10.1016/j.molcel.2020.07.026 . https://www.ncbi.nlm.nih.gov/pubmed/32810436 Cited in this article [1]

[20]	Guerini D. STING agonists/antagonists: their potential as therapeutics and future developments[J]. Cells, 2022, 11(7): 1159. PMCID: PMC8998017. DOI: 10.3390/cells11071159 . https://www.ncbi.nlm.nih.gov/pubmed/35406723 Cited in this article [1]

[21]	Decout A, Katz JD, Venkatraman S, et al. The cGAS-STING pathway as a therapeutic target in inflammatory diseases[J]. Nat Rev Immunol, 2021, 21(9): 548-569. PMCID: PMC8029610. DOI: 10.1038/s41577-021-00524-z . https://www.ncbi.nlm.nih.gov/pubmed/33833439 Cited in this article [1]

[22]	Yang Y, Huang Y, Zeng Z. Advances in cGAS-STING signaling pathway and diseases[J]. Front Cell Dev Biol, 2022, 10: 800393. PMCID: PMC8851069. DOI: 10.3389/fcell.2022.800393 . https://www.ncbi.nlm.nih.gov/pubmed/35186921 Cited in this article [1]

[23]	Downton P, Bagnall JS, England H, et al. Overexpression of IκBα modulates NF-κB activation of inflammatory target gene expression[J]. Front Mol Biosci, 2023, 10: 1187187. PMCID: PMC10203502. DOI: 10.3389/fmolb.2023.1187187 . https://www.ncbi.nlm.nih.gov/pubmed/37228587 Cited in this article [1]

[24]

Tangye SG, Al-Herz W, Bousfiha A, et al. Human inborn errors of immunity: 2022 update on the classification from the International Union of Immunological Societies Expert Committee[J]. J Clin Immunol, 2022, 42(7): 1473-1507. PMCID: PMC9244088. DOI: 10.1007/s10875-022-01289-3 . https://www.ncbi.nlm.nih.gov/pubmed/35748970 Cited in this article [1]

[25]	Harry O, Crosby LE, Smith AW, et al. Self-management and adherence in childhood-onset systemic lupus erythematosus: what are we missing?[J]. Lupus, 2019, 28(5): 642-650. PMCID: PMC6506349. DOI: 10.1177/0961203319839478 . https://www.ncbi.nlm.nih.gov/pubmed/30907294 Cited in this article [1]

[26]

Massias JS, Smith EMD, Al-Abadi E, et al. Clinical and laboratory characteristics in juvenile-onset systemic lupus erythematosus across age groups[J]. Lupus, 2020, 29(5): 474-481. PMCID: PMC7528537. DOI: 10.1177/0961203320909156 . https://www.ncbi.nlm.nih.gov/pubmed/32233733 Cited in this article [1]

[27]

Parperis K, Psarelis S, Chatzittofis A, et al. Association of clinical characteristics, disease activity and health-related quality of life in SLE patients with major depressive disorder[J]. Rheumatology (Oxford), 2021, 60(11): 5369-5378. DOI: 10.1093/rheumatology/keab123 . https://www.ncbi.nlm.nih.gov/pubmed/33547787 Cited in this article [1]

[28]	Zhang C, Deng Z, Wu J, et al. HO-1 impairs the efficacy of radiotherapy by redistributing cGAS and STING in tumors[J]. J Clin Invest, 2024, 134(23): e181044. PMCID: PMC11601901. DOI: 10.1172/JCI181044 . https://www.ncbi.nlm.nih.gov/pubmed/39621310 Cited in this article [1]

[29]	Tesser A, Piperno GM, Pin A, et al. Priming of the cGAS-STING-TBK1 pathway enhances LPS-induced release of type I interferons[J]. Cells, 2021, 10(4): 785. PMCID: PMC8067196. DOI: 10.3390/cells10040785 . https://www.ncbi.nlm.nih.gov/pubmed/33916318 Cited in this article [1]

[30]	Wobma H, Shin DS, Chou J, et al. Dysregulation of the cGAS-STING pathway in monogenic autoinflammation and lupus[J]. Front Immunol, 2022, 13: 905109. PMCID: PMC9186411. DOI: 10.3389/fimmu.2022.905109 . https://www.ncbi.nlm.nih.gov/pubmed/35693769 Cited in this article [1]

[31]	An J, Durcan L, Karr RM, et al. Expression of cyclic GMP-AMP synthase in patients with systemic lupus erythematosus[J]. Arthritis Rheumatol, 2017, 69(4): 800-807. DOI: 10.1002/art.40002 . https://www.ncbi.nlm.nih.gov/pubmed/27863149 Cited in this article [1]

[32]	Ding L, Dong G, Zhang D, et al. The regional function of cGAS/STING signal in multiple organs: one of culprit behind systemic lupus erythematosus?[J]. Med Hypotheses, 2015, 85(6): 846-849. DOI: 10.1016/j.mehy.2015.09.026 . https://www.ncbi.nlm.nih.gov/pubmed/26464144 Cited in this article [1]

[33]	Mahdaviani S, Higgins GC, Kerr NC. Orbital pseudotumor in a child with juvenile rheumatoid arthritis[J]. J Pediatr Ophthalmol Strabismus, 2005, 42(3): 185-188. DOI: 10.3928/01913913-20050501-09 . https://www.ncbi.nlm.nih.gov/pubmed/15977874 Cited in this article [1]

[34]	Sabounji MM, Lissimo H, Deme A. Childhood-onset rheumatoid arthritis at a tertiary hospital in Senegal, West Africa[J]. Pediatr Rheumatol Online J, 2023, 21(1): 98. PMCID: PMC10496368. DOI: 10.1186/s12969-023-00889-6 . https://www.ncbi.nlm.nih.gov/pubmed/37700346 Cited in this article [1]

[35]	Szekanecz Z, McInnes IB, Schett G, et al. Autoinflammation and autoimmunity across rheumatic and musculoskeletal diseases[J]. Nat Rev Rheumatol, 2021, 17(10): 585-595. DOI: 10.1038/s41584-021-00652-9 . https://www.ncbi.nlm.nih.gov/pubmed/34341562 Cited in this article [1]

[36]	Zhu Q, Zhou H. The role of cGAS-STING signaling in rheumatoid arthritis: from pathogenesis to therapeutic targets[J]. Front Immunol, 2024, 15: 1466023. PMCID: PMC11461283. DOI: 10.3389/fimmu.2024.1466023 . https://www.ncbi.nlm.nih.gov/pubmed/39386207 Cited in this article [1]

[37]	Barker BR, Taxman DJ, Ting JP. Cross-regulation between the IL-1β/IL-18 processing inflammasome and other inflammatory cytokines[J]. Curr Opin Immunol, 2011, 23(5): 591-597. PMCID: PMC3380339. DOI: 10.1016/j.coi.2011.07.005 . https://www.ncbi.nlm.nih.gov/pubmed/21839623 Cited in this article [1]

[38]

Kim JW, Ahn MH, Jung JY, et al. An update on the pathogenic role of neutrophils in systemic juvenile idiopathic arthritis and adult-onset Still's disease[J]. Int J Mol Sci, 2021, 22(23): 13038. PMCID: PMC8657670. DOI: 10.3390/ijms222313038 . https://www.ncbi.nlm.nih.gov/pubmed/34884842 Cited in this article [1]

[39]

Drougkas K, Skarlis C, Mavragani C. Type I interferons in systemic autoimmune rheumatic diseases: pathogenesis, clinical features and treatment options[J]. Mediterr J Rheumatol, 2024, 35(): 365-380. PMCID: PMC11345602. DOI: 10.31138/mjr.270324.tis . https://www.ncbi.nlm.nih.gov/pubmed/39193187 Cited in this article [1] Abstract Suppl 2

[40]	Fonseca JE, Santos MJ, Canhão H, et al. Interleukin-6 as a key player in systemic inflammation and joint destruction[J]. Autoimmun Rev, 2009, 8(7): 538-542. DOI: 10.1016/j.autrev.2009.01.012 . https://www.ncbi.nlm.nih.gov/pubmed/19189867 Cited in this article [1]

[41]	Sikora KA, Grom AA. Update on the pathogenesis and treatment of systemic idiopathic arthritis[J]. Curr Opin Pediatr, 2011, 23(6): 640-646. PMCID: PMC3315376. DOI: 10.1097/MOP.0b013e32834cba24 . https://www.ncbi.nlm.nih.gov/pubmed/22045308 Cited in this article [1]

[42]	Liu A, Ying S. Aicardi-Goutières syndrome: a monogenic type I interferonopathy[J]. Scand J Immunol, 2023, 98(4): e13314. DOI: 10.1111/sji.13314 . https://www.ncbi.nlm.nih.gov/pubmed/37515439 Cited in this article [1]

[43]

Li W, Wang W, Wang W, et al. Janus kinase inhibitors in the treatment of type I interferonopathies: a case series from a single center in China[J]. Front Immunol, 2022, 13: 825367. PMCID: PMC8995420. DOI: 10.3389/fimmu.2022.825367 . https://www.ncbi.nlm.nih.gov/pubmed/35418997 Cited in this article [1]

[44]

Goldberg G, Coelho L, Mo G, et al. TREX1 is required for microglial cholesterol homeostasis and oligodendrocyte terminal differentiation in human neural assembloids[J]. Mol Psychiatry, 2024, 29(3): 566-579. PMCID: PMC11153041. DOI: 10.1038/s41380-023-02348-w . https://www.ncbi.nlm.nih.gov/pubmed/38129659 Cited in this article [1]

[45]

Livingston JH, Crow YJ. Neurologic phenotypes associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR1, and IFIH1: Aicardi-Goutières syndrome and beyond[J]. Neuropediatrics, 2016, 47(6): 355-360. DOI: 10.1055/s-0036-1592307 . https://www.ncbi.nlm.nih.gov/pubmed/27643693 Cited in this article [1]

[46]	Uggenti C, Lepelley A, Crow YJ. Self-awareness: nucleic acid-driven inflammation and the type I interferonopathies[J]. Annu Rev Immunol, 2019, 37: 247-267. DOI: 10.1146/annurev-immunol-042718-041257 . https://www.ncbi.nlm.nih.gov/pubmed/30633609 Cited in this article [1]

[47]	Li T, Yum S, Wu J, et al. cGAS activation in classical dendritic cells causes autoimmunity in TREX1-deficient mice[J]. Proc Natl Acad Sci U S A, 2024, 121(38): e2411747121. PMCID: PMC11420187. DOI: 10.1073/pnas.2411747121 . https://www.ncbi.nlm.nih.gov/pubmed/39254994 Cited in this article [1]

[48]

de Cevins C, Delage L, Batignes M, et al. Single-cell RNA-sequencing of PBMCs from SAVI patients reveals disease-associated monocytes with elevated integrated stress response[J]. Cell Rep Med, 2023, 4(12): 101333. PMCID: PMC10772457. DOI: 10.1016/j.xcrm.2023.101333 . https://www.ncbi.nlm.nih.gov/pubmed/38118407 Cited in this article [1]

[49]	David C, Frémond ML. Lung inflammation in STING-associated vasculopathy with onset in infancy (SAVI)[J]. Cells, 2022, 11(3): 318. PMCID: PMC8834229. DOI: 10.3390/cells11030318 . https://www.ncbi.nlm.nih.gov/pubmed/35159128 Cited in this article [1]

[50]	Latour‐Álvarez I, Murcia‐Clemente L, Vázquez Pigueiras I, et al. STING-associated vasculopathy with onset in infancy (SAVI) presenting with skin lesions[J]. Pediatr Dermatol, 2024, 41(5): 893-896. DOI: 10.1111/pde.15620 . https://www.ncbi.nlm.nih.gov/pubmed/38682895 Cited in this article [1]

[51]

Clarke SLN, Robertson L, Rice GI, et al. Type 1 interferonopathy presenting as juvenile idiopathic arthritis with interstitial lung disease: report of a new phenotype[J]. Pediatr Rheumatol Online J, 2020, 18(1): 37. PMCID: PMC7218611. DOI: 10.1186/s12969-020-00425-w . https://www.ncbi.nlm.nih.gov/pubmed/32398023 Cited in this article [1]

[52]	Amadio R, Piperno GM, Benvenuti F. Self-DNA sensing by cGAS-STING and TLR9 in autoimmunity: is the cytoskeleton in control?[J]. Front Immunol, 2021, 12: 657344. PMCID: PMC8167430. DOI: 10.3389/fimmu.2021.657344 . https://www.ncbi.nlm.nih.gov/pubmed/34084165 Cited in this article [1]

[53]	Rivers E, Worth A, Thrasher AJ, et al. How I manage patients with Wiskott Aldrich syndrome[J]. Br J Haematol, 2019, 185(4): 647-655. PMCID: PMC7612067. DOI: 10.1111/bjh.15831 . https://www.ncbi.nlm.nih.gov/pubmed/30864154 Cited in this article [1]

[54]	Thrasher AJ, Burns SO. WASP: a key immunological multitasker[J]. Nat Rev Immunol, 2010, 10(3): 182-192. DOI: 10.1038/nri2724 . https://www.ncbi.nlm.nih.gov/pubmed/20182458 Cited in this article [1]

[55]	Piperno GM, Naseem A, Silvestrelli G, et al. Wiskott-Aldrich syndrome protein restricts cGAS/STING activation by dsDNA immune complexes[J]. JCI insight, 2020, 5(17): 132857. PMCID: PMC7526445. DOI: 10.1172/jci.insight.132857 . https://www.ncbi.nlm.nih.gov/pubmed/32721945 Cited in this article [1]

[56]	Vincent J, Adura C, Gao P, et al. Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice[J]. Nat Commun, 2017, 8(1): 750. PMCID: PMC5622107. DOI: 10.1038/s41467-017-00833-9 . https://www.ncbi.nlm.nih.gov/pubmed/28963528 Cited in this article [1]

[57]	Dai J, Huang YJ, He X, et al. Acetylation blocks cGAS activity and inhibits self-DNA-induced autoimmunity[J]. Cell, 2019, 176(6): 1447-1460.e14. PMCID: PMC8274936. DOI: 10.1016/j.cell.2019.01.016 . https://www.ncbi.nlm.nih.gov/pubmed/30799039 Cited in this article [2]

[58]	An J, Woodward JJ, Sasaki T, et al. Cutting edge: antimalarial drugs inhibit IFN-β production through blockade of cyclic GMP-AMP synthase-DNA interaction[J]. J Immunol, 2015, 194(9): 4089-4093. DOI: 10.4049/jimmunol.1402793 . https://www.ncbi.nlm.nih.gov/pubmed/25821216 Cited in this article [1]

[59]

Lama L, Adura C, Xie W, et al. Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression[J]. Nat Commun, 2019, 10(1): 2261. PMCID: PMC6529454. DOI: 10.1038/s41467-019-08620-4 . https://www.ncbi.nlm.nih.gov/pubmed/31113940 Cited in this article [1]

[60]

Xiong Y, Chen J, Liang W, et al. Blockade of the mitochondrial DNA release ameliorates hepatic ischemia-reperfusion injury through avoiding the activation of cGAS-sting pathway[J]. J Transl Med, 2024, 22(1): 796. PMCID: PMC11351313. DOI: 10.1186/s12967-024-05588-8 . https://www.ncbi.nlm.nih.gov/pubmed/39198913 Cited in this article [1]

[61]	Haag SM, Gulen MF, Reymond L, et al. Targeting STING with covalent small-molecule inhibitors[J]. Nature, 2018, 559(7713): 269-273. DOI: 10.1038/s41586-018-0287-8 . https://www.ncbi.nlm.nih.gov/pubmed/29973723 Cited in this article [1]

[62]

Hansen AL, Buchan GJ, Rühl M, et al. Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling[J]. Proc Natl Acad Sci U S A, 2018, 115(33): E7768-E7775. PMCID: PMC6099880. DOI: 10.1073/pnas.1806239115 . https://www.ncbi.nlm.nih.gov/pubmed/30061387 Cited in this article [1]

[63]	Li S, Hong Z, Wang Z, et al. The cyclopeptide astin C specifically inhibits the innate immune CDN sensor STING[J]. Cell Rep, 2018, 25(12): 3405-3421.e7. DOI: 10.1016/j.celrep.2018.11.097 . https://www.ncbi.nlm.nih.gov/pubmed/30566866 Cited in this article [1]

[64]

Feng M, Kong D, Guo H, et al. Gelsevirine improves age-related and surgically induced osteoarthritis in mice by reducing STING availability and local inflammation[J]. Biochem Pharmacol, 2022, 198: 114975. DOI: 10.1016/j.bcp.2022.114975 . https://www.ncbi.nlm.nih.gov/pubmed/35202579 Cited in this article [1]