Development of a quality control indicator system for neonatal screening of inherited metabolic diseases in obstetric settings

Hui LI; Jin ZHANG; Dan-Feng. CAO

doi:10.7499/j.issn.1008-8830.2412118

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Chinese Journal of Contemporary Pediatrics ›› 2025, Vol. 27 ›› Issue (8) : 994-1001. DOI: 10.7499/j.issn.1008-8830.2412118

CLINICAL RESEARCH

Development of a quality control indicator system for neonatal screening of inherited metabolic diseases in obstetric settings

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Abstract

Objective To develop a quality control indicator system for neonatal screening of inherited metabolic diseases in obstetric settings, so as to provide a standardized tool for quality control in clinical neonatal screening of inherited metabolic diseases. Methods From March to May 2024, a literature review combined with expert clinical experience was conducted to develop a preliminary questionnaire on quality control indicators for neonatal screening of inherited metabolic diseases. The final indicator system was established after two rounds of the Delphi method, and the Analytic Hierarchy Process was used to determine indicator weights. Results Sixteen questionnaires were distributed in each of the two consultation rounds, with a valid response rate of 100% for both. The expert authority coefficients were 0.863 and 0.876, respectively. Kendall's coefficient of concordance for the importance and feasibility of the indicators ranged from 0.091 to 0.125. The final indicator system comprised 3 primary indicators, 8 secondary indicators, and 28 tertiary indicators for neonatal screening of inherited metabolic diseases in obstetric settings. Conclusions The quality control indicator system developed using the Delphi method demonstrates a strong systematic structure, high clinical adaptability, and strong operability, and can be effectively applied to quality control in neonatal screening of inherited metabolic diseases in obstetric settings.

Key words

Inherited metabolic disease / Neonatal screening / Quality control / Evaluation indicator / Delphi method / Neonate

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Hui LI , Jin ZHANG , Dan-Feng. CAO. Development of a quality control indicator system for neonatal screening of inherited metabolic diseases in obstetric settings[J]. Chinese Journal of Contemporary Pediatrics. 2025, 27(8): 994-1001 https://doi.org/10.7499/j.issn.1008-8830.2412118

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